The Investigation of the Relaxation Process in Antiferroelectric Liquid Crystals by Electro-Optic Spectroscopy

Electrooptic spectroscopy of an antiferroelectric liquid crystal is carried out over a range of frequencies from 1 Hz to 100 kHz. In the antiferroelectric SmCA phase two relaxation processes are found, one at the fundamental frequency of a mode and the second at twice the frequency of a different mode. A comparison of the results of the electro-optic spectroscopy with a theoretical study of the motion of the director of an antiferroelectric helix subject to a weak alternating field enables a determination of the origin of the relaxation processes in antiferroelectric phases. © 1998 American Institute of Physics

Observation and Investigation of the Ferrielectric Subphase with qT\u3e1/2

The high-temperature femelectric phase with qT \u3e 1/2 has been found to exist in a antiferroelectric liquid crystal. This phase has been identified using dielectric spectroscopy and conoscopy

Dielectric Study of Liquid Crystals with Large Electroclinic Effect

Here we report results of the study of tilt angle and birefringence of some “high-electroclinic” materials having similar molecular structure with two and three siloxane spacers. The structure of these LC materials were studied by dielectric spectroscopy, birefringence and tilt angle measurements. Three of the four studied materials with a siloxane fragment are the deVries materials, but the siloxane-free sample is conventional SmA phase and is thus different. Possible models for the molecular structures of deVries SmA∗ phases are discussed

Observation and Investigation of the Ferrielectric Subphase with High qT Parameter.

Dielectric relaxation processes in an antiferroelectric liquid crystal ~AFLC! have been investigated over a wide range of frequencies from 1 Hz to 1 GHz. The AFLC under investigation possesses a variety of different ferrielectric, ferroelectric, and antiferroelectric phases. Dielectric and polarization measurements under direct bias voltage have been made with a view to clarifying the origin of the high-temperature ferrielectric phase, which appears between the AF and smectic-C* phases. This phase is assigned to an unstable ferrielectric phase with qT parameter greater than 1/2 ~according to the Ising model! or a doubly modulated incommensurate phase ~according to the expanded Landau model!. The results are also supported by conoscopy

Observation and Investigation of the Ferrielectric Subphase With High qT Parameter

Dielectric relaxation processes in an antiferroelectric liquid crystal (AFLC) have been investigated over a wide range of frequencies from 1 Hz to 1 GHz. The AFLC under investigation possesses a variety of different ferrielectric, ferroelectric, and antiferroelectric phases. Dielectric and polarization measurements under direct bias voltage have been made with a view to clarifying the origin of the high-temperature ferrielectric phase, which appears between the AF and smectic-C phases. This phase is assigned to an unstable ferrielectric phase with qT parameter greater than 1/2 (according to the Ising model) or a doubly modulated incommensurate phase (according to the expanded Landau model). The results are also supported by conoscopy

Nematic twist-bend phase with nanoscale modulation of molecular orientation

A state of matter in which molecules show a long-range orientational order and no positional order is called a nematic liquid crystal. The best known and most widely used (for example, in modern displays) is the uniaxial nematic, with the rod-like molecules aligned along a single axis, called the director. When the molecules are chiral, the director twists in space, drawing a right-angle helicoid and remaining perpendicular to the helix axis; the structure is called a chiral nematic. Here using transmission electron and optical microscopy, we experimentally demonstrate a new nematic order, formed by achiral molecules, in which the director follows an oblique helicoid, maintaining a constant oblique angle with the helix axis and experiencing twist and bend. The oblique helicoids have a nanoscale pitch. The new twist-bend nematic represents a structural link between the uniaxial nematic (no tilt) and a chiral nematic (helicoids with right-angle tilt)

A Study of Antiferroelectric Liquid Crystals Using the Pyroelectric Technique

Antiferroelectric liquid crystals are studied using the pyroelecmc technique. The effects of temperature and applied voltage on the pyroelectric signal are examined. The pyroelecmc signal can detect phase changes that occur due to temperature and bias voltage. A high temperature femelecmc phase FiLC is found and the stability of this phase under different bias voltages is examine

Nematic Twist-Bend Phase with Nanoscale Modulation of Molecular Orientation

Peer reviewedPublisher PD

Magnetic and transport properties of Mo substituted La0.67Ba0.33Mn1-xMoxO3 perovskite system

The effect of doping Mo for Mn on the magnetic and transport properties of the colossal magnetoresistance material, La0.67Ba0.33MnO3, has been studied. Compounds of the series La0.67Ba0.33Mn1-xMoxO3 (x=0.0 to 0.1) have been prepared and found to crystallize in the orthorhombic structure (space group Pbnm). Energy Dispersive X-ray Analysis (EDAX) measurements confirm the stoichiometry of all the samples. Magnetotransport and magnetization measurements reveal that the metal-insulator transition temperature (Tp) decreases from 330K for x=0 to 255K for x=0.1. The change in Tp on Mo substitution is relatively much smaller than the corresponding change observed on substitution by other transition elements, such as Ti, Fe, Co, Ni, etc. Further, the ferromagnetic transition temperature (TC) is nearly unchanged by Mo substitution. This is in striking contrast to the large decrease in TC observed with substitution of above-mentioned 3d elements. These unusual magnetic and transport properties of La0.67Ba0.33Mn1-xMoxO3 may be either due to the formation of magnetic pair between Mn and Mo or due to strong Mo(4d)-O(2p) overlap, which in turn, may affect the Mn-Mn interaction via the oxygen atomsComment: 25 pages, 5 figure

Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy

T-cell-based immunotherapy, such as CAR-T cells and bispecific T-cell engagers (BiTEs), has shown promising clinical outcomes in many cancers; however, these therapies have significant limitations, such as poor pharmacokinetics and the ability to target only one antigen on the cancer cells. In multiclonal diseases, these therapies confer the development of antigen-less clones, causing tumor escape and relapse. In this study, we developed nanoparticle-based bispecific T-cell engagers (nanoBiTEs), which are liposomes decorated with anti-CD3 monoclonal antibodies (mAbs) targeting T cells, and mAbs targeting the cancer antigen. We also developed a nanoparticle that targets multiple cancer antigens by conjugating multiple mAbs against multiple cancer antigens for T-cell engagement (nanoMuTEs). NanoBiTEs and nanoMuTEs have a long half-life of about 60 h, which enables once-a-week administration instead of continuous infusion, while maintaining efficacy in vitro and in vivo. NanoMuTEs targeting multiple cancer antigens showed greater efficacy in myeloma cells in vitro and in vivo, compared to nanoBiTEs targeting only one cancer antigen. Unlike nanoBiTEs, treatment with nanoMuTEs did not cause downregulation (or loss) of a single antigen, and prevented the development of antigen-less tumor escape. Our nanoparticle-based immuno-engaging technology provides a solution for the major limitations of current immunotherapy technologies