VOLTAMMETRIC DETERMINATION OF DESLORATADINE IN PHARMACEUTICAL AND HUMAN URINE SAMPLES USING GLASSY CARBON ELECTRODE

Objective: The electrochemical behaviour of Desloratadine (DLTD) in pharmaceutical and human urine samples at glassy carbon electrode was investigated by cyclic voltammetry (CV) and square wave voltammetry (SWV). Methods: A well defined reduction peak was observed at potential -1.55V in phosphate buffer solution (PBS) in basic medium. The reduction process was observed to be irreversible over the pH range from pH 2.0 to pH 10.0. The influence of different parameters such as the effect of pH, scan rate and concentration of the drug was studied. The probable reaction mechanism involved in the reduction of DLTD was also proposed. A SWV method with good recovery and accuracy was obtained for the determination of DLTD in pharmaceutical formulations and urine samples. Results: The peak currents were found to be linearly dependent on the concentration range of 2.55x10-5to 1.5x10-3M of DLTD. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 2.75x 10-9M, 3.20x 10-7 M respectively. Conclusion: The proposed method was successfully applied for determination of DLTD in pharmaceutical and human urine samples

Trade Balance and Growth of Indian Agriculture Exports

Throughout its history, India has been viewed as an agricultural country. 54.6 percent of India's population (census 2011) is employed in agriculture and related sectors, which accounted for 17.4 percent of GDP in 2016-17. (Current prices). Agriculture accounted for 10.5% of India's total exports in 2017 with a value of $33.87 billion. The paper's introduction, goals, review of literature, research methodology, growth rates in agricultural commodity trade, India's agriculture trade, government agriculture foreign trade strategy, conclusion, and recommendations are among the sections of the paper that are included. Trade in agricultural commodities in India was studied using an exponential model of the form Yt = abteu. Carl Pearson's co-relation co-efficient test was used to analyse and assess the data gathered from secondary sources, such as the economic survey, annual reports from the agriculture ministry, and so on.. After a thorough review of the data, a researcher has come up with a set of recommendations to help the Indian economy grow

Conductance Studies on the Interaction of Maltose with Alkali Metal Halides in Water & Formamide

1065-106

Quality Enhancement in Forage Crops of Cereals and Legumes

This article focus on quality improvement in forage crops, specifically grasses, cereals, and legumes. As milk and many other by-products obtained from dairy farms, poultry, etc are getting into demand, high-quality forage for livestock production is well recognized, and efforts to improve forage quality can have significant economic and environmental benefits. And an overview of current strategies for quality improvement, including breeding and genetic selection, management practices, and how these practices affect the quality of forage crops such as silica, lignin, and other phenolic components. Use of different breeding methods more over like synthetic cultivars, recurrent selection, etc. the use of biotechnology tools such as RNAi interference, tissue culture, and marker-assisted selection in the particular crop that has been developed for increasing the nutritional value, proteins that present in forage crops, and to decrease the harmful chemicals. Additionally, the paper discusses the challenges associated with quality improvement in forage crops and potential solutions. And about different types of grasses used for different types of cattle as supplements. Limitations that cause obstruction to improving the quality of forage crops. digestibility and how to increase the quality and protein content in milk and cattle. And nutrition that needs to be present in prescribed quantities in forage crops. Overall, this paper highlights the need for continued research and innovation in the field of forage crop quality improvement to support sustainable agriculture and meet the increasing demand for high-quality livestock feed

Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in rats

Background: Colorectal cancer (CRC) is a frequently diagnosed cancer that primarily affects the digestive system and an imperative cause of mortalities worldwide. Objective: In this work, we formulated the Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites (SAP-Ally-NCs) and investigated its anticancer role against the DMH-provoked CRC in rats. Methodology: The formulated SAP-Ally-NCs were characterized different techniques. The CRC was provoked to the rats via injecting 20 mg/kg of DMH and then administered with the formulated SAP-Ally-NCs for 16 weeks. The bodyweight changes and the polyp’s incidences were detected and tabulated. The status of lipid peroxidation and antioxidant enzymes were studied by standard techniques. The inflammatory markers and xenobiotic enzymes level was scrutinized using respective kits. The mRNA expressions of various signaling molecules were examined by RT-PCR. The liver and colon tissues were examined microscopically to detect the histological changes. Results: The formulated SAP-Ally-NCs treatment appreciably improved the body weight gain and suppressed the polyp’s incidences in the DMH-challenged animals. SAP-Ally-NCs treated animals were demonstrated the notable reduction in the lipid peroxidation and inflammatory cytokines and elevated the antioxidant enzymes i.e. CAT and SOD activity. SAP-Ally-NCs administered animals exhibited the noticeable reduction in the expression of PCNA, cyclin-D1, iNOS, and COX-2 in the colon tissues. The histological findings also unveiled the therapeutic role of SAP-Ally-NCs. Conclusion: In conclusion, the SAP-Ally-NCs demonstrated the potent anticancer action against the DMH-provoked CRC in rats. In future, it could be a potent chemotherapeutic agent to the CRC