Las ocho regiones naturales del Perú

PRIMERA PARTE Introducción 1. Generalidades Consideramos que Región Natural es un área continua o discontinua, en la cual son comunes o similares el mayor número de factores del medio ambiente natural; y que, dentro de dichos factores, el hombre juega papel principalísimo como el más activo agente modificador de la naturaleza. En el Perú, casi todos los paisajes conllevan la obra humana, ostensible u ocultamente; y no existe una sola región, salvo en los cortos sectores vacíos del ecúmene, e..

Apuntes para la historia de la Tadeo

No hablaré para los viejos. Quiero hablar a los jóvenes, porque es sabido en el mundo que la reciente historia es siempre la más desconocida, y así, evidentemente, a los alumnos aquí presentes, a los profesores jóvenes, a los miembros del Consejo Directivo que también son recientes, quiero decirles que hace 36 años la idea de universidad que ahora es la Universidad de Bogotá Jorge Tadeo Lozano, era sólo una idea oscura y al mismo tiempo clara que se había posesionado del espíritu de tres personas: Joaquín Molano Campuzano, Jaime Forero Valdés y quien les habla

Milk collection, milk processing and marketing of dairy products in Guyana

The table of contents for this item can be shared with the requester. The requester may then choose one chapter, up to 10% of the item, as per the Fair Dealing provision of the Canadian Copyright Ac

Utilization of High Milk-Protein Powder in Bulk Starter Production and Manufacture of Gouda Cheese

Membrane separation is a process based on the selective permeability of one or more components in a liquid mixture through a membrane barrier. The driving force is the hydrostatic pressure gradient required to overcome the osmotic pressure against which the water flow occurs. It can be used as concentration or fractionation operation to produce two liquid streams of different compositional characteristics: the retentate or fraction retained by the membrane, and the permeate or fraction which permeates the membrane (30

Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib.

Sunitinib is the currently standard treatment for metastatic renal cell carcinoma (mRCC). Multiple candidate predictive biomarkers for sunitinib response have been evaluated but none of them has been implemented in the clinic yet. The aim of this study was to analyze single nucleotide polymorphisms (SNPs) in genes linked to mode of action of sunitinib and immune response as biomarkers for mRCC. This is a multicenter, prospective and observational study involving 20 hospitals. Seventy-five mRCC patients treated with sunitinib as first line were used to assess the impact of 63 SNPs in 31 candidate genes on clinical outcome. rs2243250 (IL4) and rs5275 (PTGS2) were found to be significantly associated with shorter cancer-specific survival (CSS). Moreover, allele C (rs5275) was associated with higher PTGS2 expression level confirming its functional role. Combination of rs5275 and rs7651265 or rs2243250 for progression free survival (PFS) or CSS, respectively, was a more valuable predictive biomarker remaining significant after correction for multiple testing. It is the first time that association of rs5275 with survival in mRCC patients is described. Two-SNP models containing this functional variant may serve as more predictive biomarkers for sunitinib and could suppose a clinically relevant tool to improve the mRCC patient management