Fuentes de financiamiento en el desarrollo económico empresa Inversiones Veneros SAC. Chimbote, 2017

Investigación que tuvo por objetivo general determinar la influencia de las fuentes de financiamiento en el desarrollo económico empresa Inversiones Veneros S.A.C. Para dicha investigación se utilizó el enfoque cuantitativo de tipo descriptivo correlacional ya que se estudió la influencia que existe entre las fuentes de financiamiento y el desarrollo económico de la empresa caso de estudio en esta investigación. El diseño fue no experimental de corte transversal; fue no experimental debido a que no se manipularon las variables y, de corte transversal, ya que se tomaron los datos en un solo momento. Se utilizó la técnica de la encuesta aplicada a Gerencia General, Administración, Tesorería, Créditos, Cobranza, Ventas de la empresa. Encontrando los siguientes resultados : El 83% menciona que la empresa solicita fuentes de financiamiento anual y el 50% recurren a micro financieras al momento de solicitar un crédito y el 83% manifestaron que la adquisición de productos en crédito mejoró el desarrollo de su empresa; el 67% consideran que los ingresos de su empresa han incrementado con las fuentes de financiamiento; mientras que 67% manifestaron que las fuentes de financiamiento han incrementado las ventas de su empresa. El 67% de las personas encuestadas manifestaron el recursos humanos en su empresa ha mejorado la calidad de vida de sus trabajadores. El 50% de las personas encuestadas manifestaron que han adquirido equipos para su empresa; y en 67% manifestaron que han invertido en implementado de equipos en su empresa y en un 80% manifestaron que la compra de recursos tecnológicos ha incrementado sus procesos óptimos en su empresa. Se concluye que las fuentes de financiamiento ha demostrado una influencia positiva debido que contribuido a un desarrollo económico en la empresa Inversiones Veneros SAC.Tesi

Exportacion de Ensis Macha al mercado español en el periodo 2011-2016

Esta investigación tiene como objetivo determinar la evolución de la Oferta Exportable del molusco Navaja - Ensis Macha al mercado español, periodo 2011 – 2019. El diseño utilizado en la presente investigación es ex post facto, no experimental; por ende, fue necesario la compilación de datos ya existentes en las diferentes fuentes públicas como el INEI, Banco Central de Reserva, SIICEX, SUNAT y fuentes privadas tales como Trade Map, Investment Map, entre otros, para hacer el análisis del producto exportable se consideró calibrar los siguientes indicadores valor de exportación, volumen de exportación (TM) y precio de exportación. La presentación de los datos obtenidos en los indicadores se ejecutó usando cuadros y gráficos estadísticos, donde se muestra las pruebas de las diferentes tendencias generadas en el periodo 2011-2019. Se obtuvo como juicio dirigente a través de la evaluación de las hipótesis y los indicadores mediante el programa Excel 2010, la presentación de los resultados observados en la oferta exportable de Ensis Macha al mercado español en el periodo 2011- 2019, con respecto a los indicadores estudiados, no ha tenido una tendencia creciente sostenible en el Perú

Implementación de las herramientas ERP y WMS y su influencia en el tiempo de entrega de mercadería en las empresas de trasporte de operaciones logísticas entre los años 2005 y 2020: una revisión de la literatura científica

Las empresas de transporte de operadores logísticos tienen una premura en usar herramientas de vanguardia para disminuir las ineficiencias del proceso de la distribución física. El objetivo de esta revisión fue determinar la influencia de las herramientas ERP y WMS en el tiempo de entrega de mercadería de las empresas de transporte de operaciones logísticas. Las bases de datos usadas para esta investigación fueron Proquest, Google Academics, Redalyc, Scielo y Ebscohost. Asimismo, se tomaron para el análisis final 23 estudios relacionados directamente con el tema tratado, con 15 años de publicación (2005-2020), en español, con estructura IMRD, de bases de datos de calidad y que fueran preferiblemente artículos científicos con revisión de pares. La evaluación y método de síntesis de las investigaciones se realizó a través de una tabla de inducción de categorías con los aportes más relevantes. Los resultados indicaron que la aplicación ERP Y WMS generalmente deriva en un marcado aumento de la productividad, así como de una reducción considerable del tiempo de entrega de mercaderías. Finalmente, se concluyó que la implementación de las herramientas ERP y WMS podría mejorar el tiempo de entrega de mercaderías en las empresas de transporte de operaciones logísticas de manera significativa sin sacrificar la calidad en el proceso de despacho

Micropatterned 3D-printed PLLA/PLCL bioresorsable stents: degradation and influence of sterilization

Bioresorbable stents (BRS) are cylindrical scaffolds designed to provide a temporary support to the vessel wall while the structure slowly degrades until completely resorbed [1]. Current stent fabrication technology hinders local modification of the surface topography. This work presents a novel solvent-cast direct-write (SC-DW) 3D printing system to manufacture inner patterned BRS. Poly-L-lactic acid (PLLA) and poly(lactic-co-caprolactone) (PLCL) stents were obtained by cylindrical printing onto a Ø 3 mm rotating mandrel (Figure 1a) [2]. The ink consisted in a solution of high Mw PLLA or PLCL copolymer (95:5) in chloroform at 10% w/v and 12.5% w/v, respectively. Steel mandrels were modified by direct laser interference patterning with a femtosecond laser to obtain a linear micropatterning with a periodicity of 10 μm, which was transferred onto stents' luminal surface (Figure 1b). Stents biodegradation was characterized by an accelerated degradation assay in PBS at 50oC over 4 months and characterized in terms of mass loss, SEM, DSC, mechanical tests, GPC and 1 H-NMR. PLLA and PLCL stents underwent bulk degradation, with a sustained decrease in molecular weight and an increase in crystallinity as degradation proceeded. PLCL stents degraded 1.5 times faster than PLLA stents due to higher water penetration in amorphous regions. Finally, two sterilization methods were evaluated: γ-irradiation (8 kGy) and ethylene oxide (EtO). Whereas γ- irradiation induced chain scission and a marked decrease in molecular weight, no structural or chemical alterations were found after EtO sterilization (Figure 1c). In conclusion, customizable PLLA and PLCL BRS were successfully fabricated through SC-DW technique, showing luminal micropatterning for enhanced endothelialization and adequate degradation timeframe for resorption

Caracterización etnozootécnica de camélidos sudamericanos domésticos

Se realizará una breve revisión del concepto de primariedad y de la metodología de Estructura Poblacional, describiendo los antecedentes, los protocolos utilizados y situaciones de aplicación en Camélidos Sudamericanos domésticos.Fil: Hick, Michel Victor Hubert. CONICET. Irnasus ; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina. Universidad Nacional de La Rioja, Sede Chamical; ArgentinaFil: Riva de Neyra, Leonardo Atilio. Universidad Nacional de La Rioja, Sede Chamical; Argentin

Acute kidney injury contributes to worse physical and quality of life outcomes in survivors of critical illness

Objectives: Survivors of critical illness and acute kidney injury (AKI) are at risk of increased morbidity. The purpose of this study was to compare physical, emotional, and cognitive health in survivors of critical illness with and without AKI. Methods: Retrospective cohort study of adult (≥ 18 years old) survivors of critical illness due to sepsis and/or acute respiratory failure who attended follow-up in a specialized ICU Recovery Clinic. Outcomes were evaluated during 3-month visit and comprised validated tests for evaluation of physical function, muscle strength, cognitive and emotional health, and self-reported health-related quality of life (HRQOL). Descriptive statistics and group comparisons were performed. Results: A total of 104 patients with median age of 55 [49-64] years, 54% male, and median SOFA score of 10 [8-12] were analyzed. Incidence of AKI during ICU admission was 61 and 19.2% of patients required renal replacement therapy (RRT). Patients with AKI stage 2 or 3 (vs. those with AKI stage 1 or no AKI) walked less on the 6-min walk test (223 ± 132 vs. 295 ± 153 m, p = 0.059) and achieved lower of the predicted walk distance (38% vs. 58%, p = 0.041). Similar patterns of worse physical function and more significant muscle weakness were observed in multiple tests, with overall worse metrics in patients that required RRT. Patients with AKI stage 2 or 3 also reported lower HRQOL scores when compared to their counterparts, including less ability to return to work or hobby, or reengage in driving. There were no significant differences in cognitive function or emotional health between groups. Conclusions: Survivors of critical illness and AKI stage 2 or 3 have increased physical debility and overall lower quality of life, with more impairment in return to work, hobby, and driving when compared to their counterparts without AKI or AKI stage 1 at 3 months post-discharge

Solvent-cast direct-writing and electrospinning as a dual fabrication strategy for drug-eluting polymeric bioresorbable stents

Bioresorbable stents (BRS) are conceived to retain sufficient radial strength after implantation while releasing an antiproliferative drug in order to prevent vessel restenosis until complete resorption. Ongoing research trends involve the use of innovative manufacturing techniques to achieve thinner struts combined with optimized local drug delivery. This work presents a combination of solvent-cast direct-writing (SC-DW) and electrospinning (ES) using poly-l-lactic acid (PLLA) and poly(l-lactic-co-¿-caprolactone) (PLCL) as a new approach to generate everolimus-eluting BRS for cardiovascular applications. A Design of Experiment (DoE) was conducted to determine the optimal parameters to obtain a homogeneous coating with high specific surface. Manufactured stents were characterized by means of mechanical tests and scanning electron microscopy (SEM), with everolimus release in accelerated conditions quantified through High Performance Liquid Chromatography (HPLC). Drug loading was achieved either encapsulated in the struts of the stent or in an electrospun PLCL membrane covering the stent. In the former case, everolimus release was found to be insufficient, less than 3% of total drug loading after 8 weeks. In the latter, everolimus release considerably increased with respect to drug-loaded 3D-printed stents, with over 50% release in the first 6 hours of the test. In conclusion, everolimus release from PLCL-coated 3D-printed stents would match the dose and timeframe required for in vivo applications, while providing thinner struts than SC-DW drug-loaded stents.Peer ReviewedPostprint (published version

Solvent-cast direct-writing as a fabrication strategy for radiopaque stents

Bioresorbable stents (BRS) potential in treating coronary heart disease is still to be further developed. Current trends include research with new polymeric materials, the need for thinner struts combined with appropriate mechanical properties, radiopacity and optimized local drug delivery. This work presents a novel solvent-cast direct-write (SC-DW) printing system to manufacture BRS onto a rotating cylinder with poly-l-lactic acid (PLLA) and poly(l-lactic-co- ¿ -caprolactone) (PLCL) inks. Printed stents were characterized in terms of mechanical, thermal and biological properties with human umbilical vein endothelial cells (HUVECs). Expansion assays showed that stents withstood pressures of at least 16 atm and the indirect cytotoxicity test indicated that stents were biocompatible. Polymeric inks were further modified with the addition of 3 radiopaque agents, namely iodine, triiodobenzoic acid (TIBA) and barium sulfate (BaSO) to render stents radiopaque. Subsequent characterization showed a general increase in strut thickness with respect to control PLLA or PLCL stents, which in turn resulted in higher resistance to compression. Microcomputed tomography was used to assess stents’ radiopacity, showing that TIBA and BaSO-containing stents presented high X-ray attenuation values and maintained their radiopacity after 3 months incubation time.Peer ReviewedPostprint (published version

Kidney Recovery in Patients with Acute Kidney Injury Treated in Outpatient Hemodialysis or Rehabilitation Facilities

Rationale & Objective: Since January 2017, patients with acute kidney injury requiring dialysis (AKI-D) can be discharged to outpatient dialysis centers for continued hemodialysis (HD) support. We aimed to examine the rate of kidney recovery, time to recovery, and hospitalization-related clinical parameters associated with kidney recovery in patients with AKI-D. Study Design: Single-center prospective cohort study. Setting & Participants: 111 adult patients who were admitted to the University of Kentucky Hospital, experienced AKI-D, and were discharged with need of outpatient HD. Exposure: Hospitalization-related clinical parameters were evaluated. Outcome: Kidney recovery as a composite of being alive and no longer requiring HD or other form of kidney replacement therapy. Analytical Approach: Discrete-time survival analysis and logistic regression were used to determine adjusted probabilities of kidney recovery at prespecified time points and to evaluate clinical parameters associated with recovery. Results: 45 (41%) patients recovered kidney function, 25 (55.5%) within the first 30 days following discharge, 16 (35.5%) within 30 to 60 days, and 4 (9%) within 60 to 90 days. Adjusted probabilities of recovery were 36.7%, 27.4%, and 6.3%, respectively. Of the remaining patients, 49 (44%) developed kidney failure requiring chronic kidney replacement therapy and 17 (15%) died or went to hospice. Patients who did not recover kidney function were older, had more comorbid conditions, had lower estimated glomerular filtration rates at baseline, and received more blood transfusions during hospitalization when compared with those who recovered kidney function. Limitations: Selection bias given that patients included in the study were all eligible for AKI management with outpatient HD as part of Medicare/Medicaid services. Conclusions: At least one-third of AKI-D survivors discharged from an acute care hospital dependent on HD recovered kidney function within the first 90 days of discharge, more commonly in the first 30 days postdischarge. Future studies should elucidate clinical parameters that can inform risk classification and interventions to promote kidney recovery in this vulnerable and growing population

Safety, Feasibility, and Efficacy of Early Rehabilitation in Patients Requiring Continuous Renal Replacement: A Quality Improvement Study

Introduction: Early rehabilitation in critically ill patients is associated with improved outcomes. Recent research demonstrates that patients requiring continuous renal replacement therapy (CRRT) can safely engage in mobility. The purpose of this study was to assess safety and feasibility of early rehabilitation with focus on mobility in patients requiring CRRT. Methods: Study design was a mixed methods analysis of a quality improvement protocol. The setting was an intensive care unit (ICU) at a tertiary medical center. Safety was prospectively recorded by incidence of major adverse events including dislodgement of CRRT catheter, accidental extubation, bleeding, and hemodynamic emergency; and minor adverse events such as transient oxygen desaturation \u3e 10% of resting. Limited efficacy testing was performed to determine if rehabilitation parameters were associated with clinical outcomes. Results: A total of 67 patients (54.0 ± 15.6 years old, 44% women, body mass index 29.2 ± 9.3 kg/m2) received early rehabilitation under this protocol. The median days of CRRT were 6.0 (interquartile range [IQR], 2–11) and 72% of patients were on mechanical ventilation concomitantly with CRRT at the time of rehabilitation. A total of 112 rehabilitation sessions were performed of 152 attempts (74% completion rate). No major adverse events occurred. Patients achieving higher levels of mobility were more likely to be alive at discharge (P = 0.076). Conclusions: The provision of early rehabilitation in critically ill patients requiring CRRT is safe and feasible. Further, these preliminary results suggest that early rehabilitation with focus on mobility may improve patient outcomes in this susceptible population