sj-docx-1-imj-10.1177_10815589231164777 – Supplemental material for Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis

Supplemental material, sj-docx-1-imj-10.1177_10815589231164777 for Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis by Vikash Jaiswal, Song Peng Ang, Helen Huang, Navroop Kaur Momi, Maha Hameed, Sidra Naz, Nitya Batra, Angela Ishak, Neel Doshi, Asmita Gera, Medha Sharath, Madeeha Subhan Waleed, Nishchita Raj and Victor Hugo Aguilera Alvarez in Journal of Investigative Medicine</p

SGLT2 inhibitors among patients with heart failure with preserved ejection fraction: a meta-analysis of randomised controlled trials

Background: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been recommended in the practice guidelines for the treatment of patients with heart failure with reduced ejection fraction; however, their effects among patients with preserved ejection fraction have been debatable. Objective: We aim to evaluate the SGLT2 inhibitor effect among patients with heart failure with reduced ejection fraction, including DELIVER and EMPEROR-Preserved trials. Methods: We performed a systematic literature search using the PubMed, Embase, Scopus, and Cochrane libraries for relevant articles from inception until August 30th, 2022. Statistical analysis was performed by calculating hazard ratio (HR) using the random effect model with a 95% confidence interval (CI) and probability value (P). Statistical significance was met if 95% CI does not cross numeric "1" and P Results: Six studies with a total of 15,989 total patients were included in the final analysis. The mean age of patients enrolled in SGLT2 inhibitors and placebo was 69.13 and 69.37 years, respectively. The median follow-up duration was 2.24 years. SGLT2 inhibitors reduced composite cardiovascular mortality or first hospitalization for heart failure (HR, 0.80 [95% CI: 0.74-0.87], P Conclusion: Our study finding shows that SGLT2 inhibitors significantly reduced the risk of first HF hospitalization or cardiovascular death and HF hospitalization; however, all-cause mortality was comparable between the groups.</p