Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)

Cases were patients with complicated urinary tract infection (cUTI), complicated intraabdominal (cIAI), pneumonia or bacteraemia from other sources (BSI-OS) due to CRE; control groups were patients with infection caused by carbapenem-susceptible Enterobacterales (CSE), and by non-infected patients, respectively. Matching criteria included type of infection for CSE group, ward and duration of hospital admission. Conditional logistic regression was used to identify risk factors. Findings Overall, 235 CRE case patients, 235 CSE controls and 705 non-infected controls were included. The CRE infections were cUTI (133, 56.7%), pneumonia (44, 18.7%), cIAI and BSI-OS (29, 12.3% each). Carbapenemase genes were found in 228 isolates: OXA-48/like, 112 (47.6%), KPC, 84 (35.7%), and metallo-beta-lactamases, 44 (18.7%); 13 produced two. The risk factors for CRE infection in both type of controls were (adjusted OR for CSE controls; 95% CI; p value) previous colonisation/infection by CRE (6.94; 2.74-15.53; <0.001), urinary catheter (1.78; 1.03-3.07; 0.038) and exposure to broad spectrum antibiotics, as categorical (2.20; 1.25-3.88; 0.006) and time-dependent (1.04 per day; 1.00-1.07; 0.014); chronic renal failure (2.81; 1.40-5.64; 0.004) and admission from home (0.44; 0.23-0.85; 0.014) were significant only for CSE controls. Subgroup analyses provided similar results. Interpretation The main risk factors for CRE infections in hospitals with high incidence included previous coloni-zation, urinary catheter and exposure to broad spectrum antibiotics

Accelerating gender and sexuality inclusion in organisations:Introduction to the special issue and academic agenda

Gender identity, sexual characteristics and sexual orientation are fundamental dimensions of human life, and we must understand how they relate to organisational and work processes to address workplace inclusion. This special issue was conceived to showcase contemporary research about approaches to accelerate gender and sexuality inclusion in organisations. Here, we introduce the five papers included in this special issue – outlining their logic, variety of methods and contributions. Then we present an agenda of academic work across research, teaching and leadership to further our knowledge of what works and facilitate the translation of that knowledge into inclusive organisational practice. JEL Classification: M14, M12, J16, D23, O15.</p

Accelerating gender and sexuality inclusion in organisations:Introduction to the special issue and academic agenda

Gender identity, sexual characteristics and sexual orientation are fundamental dimensions of human life, and we must understand how they relate to organisational and work processes to address workplace inclusion. This special issue was conceived to showcase contemporary research about approaches to accelerate gender and sexuality inclusion in organisations. Here, we introduce the five papers included in this special issue – outlining their logic, variety of methods and contributions. Then we present an agenda of academic work across research, teaching and leadership to further our knowledge of what works and facilitate the translation of that knowledge into inclusive organisational practice. JEL Classification: M14, M12, J16, D23, O15.</p

Microfluidic Reactors for Carbon Fixation under Ambient-Pressure Alkaline-Hydrothermal-Vent Conditions

The alkaline-hydrothermal-vent theory for the origin of life predicts the spontaneous reduction of CO2, dissolved in acidic ocean waters, with H2 from the alkaline vent effluent. This reaction would be catalyzed by Fe(Ni)S clusters precipitated at the interface, which effectively separate the two fluids into an electrochemical cell. Using microfluidic reactors, we set out to test this concept. We produced thin, long Fe(Ni)S precipitates of less than 10 &#181;m thickness. Mixing simplified analogs of the acidic-ocean and alkaline-vent fluids, we then tested for the reduction of CO2. We were unable to detect reduced carbon products under a number of conditions. As all of our reactions were performed at atmospheric pressure, the lack of reduced carbon products may simply be attributable to the low concentration of hydrogen in our system, suggesting that high-pressure reactors may be a necessity