Cinnamoylgrandifloric Acid From Mikania Oblongifolia

Isolation of the cinnamate of grandifloric acid from Mikania oblongifolia is reported. © 1977.161220282029Vichnewski, Sarti, Gilbert, Herz, (1976) Phytochemistry, 15, p. 191Herz, Subramaniam, Murari, Dennis, Blount, (1977) J. Org. Chem., 42, p. 1720Hanson, Siverens, Piozzi, Savona, The 13C nuclear magnetic resonance spectra of kauranoid diterpenes (1976) Journal of the Chemical Society, Perkin Transactions 1, p. 114Yamasaki, Kohda, Kobayashi, Kasai, Tanaka, (1976) Tetrahedron Letters, p. 1005Temai, Markham, (1976) Tetrahedron, 32, p. 565Herz, Sharma, (1976) J. Org. Chem., 41, p. 1021Piozzi, Sprio, Passannanti, Mondelli, (1968) Gazz. Chim. Ital., 98, p. 907Brieskorn, Pohlmann, (1969) Chem. Ber., 102, p. 2621Yahara, Ishida, Yamasaki, Tanaka, Mihashi, (1974) Chem. Pharm. Bull., 22, p. 1629Bohlmann, Le, (1977) Phytochemistry, 16, p. 57

Bioactivity Of Flavonoids Isolated From Lychnophora Markgravii Against Leishmania Amazonensis Amastigotes

The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes. © 2009 Verlag der Zeitschrift für Naturforschung, Tübingen.647-8509512Agrawal, P.K., (1989) Carbon-13 NMR of Flavonoids, p. 564. , Elsevier, AmsterdamCoile, N.C., Jones, S.B., Lychnophora (Compositae: Vernonieae), a genus endemic to the Brazilian planalto (1981) Brittonia, 33, pp. 528-542Gobbo-Neto, L., Lopes, N.P., Online identification of chlorogenic acids, sesquiterpene lactones, and flavonoids in the Brazilian arnica Lychnophora ericoides Mart. (Asteraceae) leaves by HPLC-DAD-MS and HPLC-DAD-MS/MS and a validated HPLC-DAD method for their simultaneous analysis (2008) J. Agric. Food Chem, 56, pp. 1193-1204Grael, C.F.F., Vichnewski, W., Souza, G.E.P., Lopes, J.L.C., Albuquerque, S., Cunha, R.W., A study of the trypanocidal and analgesic properties from Lychnophora granmongolense (Duarte) Semir & Leitao Filho (2000) Phytother. Res, 14, pp. 203-206Harborne, J.B., The Flavonoids: Advances in Research since 1986 (1996) The Flavonoids, pp. 450-453. , Chapman and Hall, London. Markam K. R. and Geiger H. (1994), 1H nuclear magnetic resonance spectroscopy of flavonoids and their glycosides in hexadeuterodimethylsufoxide Harborne J. B., ed.). Chapman and Hall, LondonMosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays (1983) J. Immunol. Methods, 65, pp. 55-63Pral, E.M.F., Moitinho, M.L.R., Balanco, J.M.F., Teixeira, J.R., Mider, R.V., Alfieri, S.C., Growth phase and medium pH modulate the expression of proteinase activities and the development of megasomes in axenically cultivated Leishmania (Leish-mania) amazonensis amastigotes-like organisms (2003) J. Parasitol, 89, pp. 35-43Robinson, H., Generic and subtribal classification of American Vernonieae (1999) Smithson. Contrib. Bot, 89, pp. 1-116Sakamoto, H.T., Flausino, D., Catellano, E.E., Stark, C.B.W., Gates, P.J., Lopes, N.P., Sesquiterpene lactones from Lychnophora ericoides (2003) J. Nat. Prod, 66, pp. 693-695Salvador, M.J., Ferreira, E.O., Pral, E.M.F., Alfieri, S.C., Albuquerque, S., Ito, I.Y., Dias, D.A., Bioactivity of crude extracts and some constituents of Blutaparon portulacoides (Amaranthaceae) (2002) Phytomedicine, 9, pp. 566-571Santos, M.D., Gobbo-Neto, L., Albarella, L., Souza, G.E.P., Lopes, N.P., Analgesic activity of di-caffeoylquinic acids from roots of Lychnophora ericoides (arnica da serra) (2005) J. Ethnopharmacol, 96, pp. 545-549Sartori, F.T., Sacilotto, A.C.B., Lopes, J.L.C., Lopes, N.P., Vichnewski, W., Phytochemical study of Lychnophora markgravii (Asteraceae) (2002) Biochem. Syst. Ecol, 30, pp. 609-612Takeara, R., Albuquerque, S., Lopes, N.P., Lopes, J.L.C., Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae) (2003), 10, pp. 490-493Taleb-Contini, S.H., Salvador, M.J., Balanco, J.M.F., Albuquerque, S., de Oliveira, D.C.R., Antiprotozoal effect of crude extracts and flavonoids isolated from Chromolaena hirsuta (Asteraceae) (2004) Phytother. Res, 18, pp. 250-25

CHEMOPROPHYLAXIS OF SCHISTOSOMOSIS - MOLLUSCICIDAL ACTIVITY OF NATURAL-PRODUCTS - TESTS WITH ADULT SNAILS AND EGGS

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