2 research outputs found
Conjugated Polymer Network Films of Poly(<i>p</i>-phenylene vinylene) with Hole-Transporting Carbazole Pendants: Dual Photoluminescence and Electrochromic Behavior
A series of poly(<i>p</i>-phenylene vinylene)
(PPV) copolymers
functionalized with hole-transport and electrochemically active carbazole
units as pendant moieties is reported. These polymers exhibit photoluminescence
properties by virtue of the PPV analogous backbone. They were also
designed as precursor polymer bearing the electroactive carbazole
group to form conjugated polymer network (CPN) films by electrodeposition.
The electrochemical polymerization of the pendant units eventually
lead to a dual property electro-optically active thin film
photoluminescence (PL) behavior that can be attenuated with CPN formation,
and a reversible doping and dedoping processes at controlled potentials
that lead to an electrochromic behavior. This reveals the ability
to incorporate complementary optical and electro-optical properties
within the same film using the CPN approach. It should be possible
to design and synthesize other PPV π-conjugated polymers with
efficient pendant hole-transport groups exhibiting tunable PL and
electrochromism with cross-linking
Evolution of a Scale-Up Synthesis to a Potent GluN2B Inhibitor and Its Prodrug
This paper describes the efficient
scale-up synthesis of the potent
negative allosteric glutamate N2B (GluN2B) inhibitor <b>1</b> (BMS-986169), which relies upon a stereospecific S<sub>N</sub>2
alkylation strategy and a robust process for the preparation of its
phosphate prodrug <b>28</b> (BMS-986163) from parent <b>1</b> using POCl<sub>3</sub>. A deoxyfluorination reaction employing bis(2-methoxyethyl)aminosulfur
trifluoride (Deoxo-Fluor) is also used to stereospecifically introduce
a fluorine substituent. The optimized routes have been demonstrated
to provide APIs suitable for toxicological studies in vivo