Valutazione della risposta sismica locale attraverso l’applicazione di metodologie multidisciplinari comparate: gli esempi di Fivizzano e Licciana Nardi (Toscana Settentrionale)

The seismic hazard studies carried out at the scale of district area, as commonly known, aim at preventing damages from local site response. These studies involve numerous disciplines whose specific competences are useful to describe the complex phenomenon such as free field seismic response. The VEL project, supported by the Tuscany Region, has been carrying out by means of this multidisciplinary standpoint in order to define the seismic risk level in the most active seismic areas of Tuscany (Garfagnana, Lunigiana, Amiata, Valtiberina and Mugello). In this work results from in situ measurements and numerical analyses at Fivizzano and Licciana Nardi villages are presented below and discussed. The seismic investigations in Lunigiana, where the villages are situated, involved historical, seismological, geophysical, geological and geotechnical studies which accurately reconstruct soil deposit models to be implemented into two-dimensional numerical dynamic analyses for local site response previsions

Oxaliplatin, irinotecan, and fluorouracil/folinic acid in advanced gastric cancer: a multicenter phase II trial of the Southern Italy Cooperative Oncology Group

Methods. Patients with unresectable or metastatic gastric cancer, unexposed to palliative chemotherapy, received oxaliplatin 85 mg/m2 iv and irinotecan 150 mg/m2 iv on day 1, 6S-folinic acid 250 mg/m2 iv and fluorouracil 750 mg/m2 iv on day 2, every 2 weeks. Response rate (RR) was assessed after a minimum of four cycles, and treatment continued up to 12 cycles. Results. Sixty-three patients were treated, with a median of eight (range 1–12) cycles/patient. Two complete and 19 partial responses were registered (RR 33% [95% CI, 22–46%]). Median progression-free survival was 7.5 (95% CI, 5.6–9.4) months, and median overall survival was 12.1 (95% CI, 10.8–13.4) months. Most common grade ≥3 toxicities were neutropenia (59%), febrile neutropenia (7%), vomiting (20%), and diarrhoea (10%). All-grade neurotoxicity affected 33% of patients. Conclusions. Oxaliplatin, irinotecan, and fluorouracil/folinic acid administered every 2 weeks are safe and active in advanced gastric cancer