Intrasubject variation in elimination half-lives of drugs which are appreciably metabolized

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45026/1/10928_2005_Article_BF01059628.pd

Facilitation of opiate-and enkephalin-induced motor activity in the mouse by phenytoin sodium and carbamazepine

In the first experiment, adult male Swiss-Webster mice were systemically injected with a standard dose of morphine. Compared to the influence of vehicle, the motor activity of morphine-injected mice was increased. Neither phenytoin sodium nor carbamazepine alone facilitated motor activity, but pretreatment with both drugs further facilitated the increased motor activity produced by morphine. In a second experiment, mice were injected centrally with a long-acting analog of leu-enkephalin. It also increased motor activity in comparison with vehicle. Again, both phenytoin sodium and carbamazepine further facilitated this response. Both experiments suggest a facilitatory interaction between some aspects of these anticonvulsants and opiate-induced motor activity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46410/1/213_2004_Article_BF00491980.pd