Under a Bridge, At Missions and Shelters, In Alleyways, Wherever I Woke Up: An Exploration of How Structural and Everyday Factors Impact Mental Health Issues and Survival Strategies Among Young Homeless Women in London, Ontario

This thesis examines how structural and everyday factors impact the survival strategies and mental health issues of young homeless females in London, Ontario. Data were gathered through secondary analysis of information from a larger study of service utilization and mental illness among homeless youth in London, and fieldnotes were also collected. The most important findings pertain to how these youth navigate the complicated terrain of daily life and the multitude of social and health-related services that they struggle to obtain and desperately need. The participants’ experiences with healthcare, justice, and social support systems, reveal a multitude of intersecting structural barriers that make obtaining these much needed resources almost insurmountable, which often exacerbates their already vulnerable status as homeless females within the volatile context of street life. These data contribute important insights regarding the development of programs and policies that reflect and better account for these girls’ challenging living situations

A minor role of asparaginase in predisposing to cerebral venous thromboses in adult acute lymphoblastic leukemia patients

Cerebral venous thrombosis (CVT) covers up to a third of all venous thromboses (VTs) detected in patients with acute lymphoblastic leukemia (ALL). It usually hampers patients' lives and may also endanger efficient leukemia treatment. Although many factors have been suggested to account for an elevated risk of VTs in patients with ALL, there still is a lack of studies focusing on CVTs and especially in the setting of adult ALL patients. We studied in our retrospective population-based cohort the occurrence, characteristics, as well as risk factors for VTs in 186 consecutively diagnosed Finnish adult ALL patients treated with a national pediatric-inspired treatment protocol ALL2000. In the risk factor analyses for VTs we found a distinction of the characteristics of the patients acquiring CVT from those with other kinds of VTs or without thrombosis. In contrast to previous studies we were also able to compare the effects of asparaginase in relation to CVT occurrence. Notably, more than half of the CVTs were diagnosed prior the administration of asparaginase which accentuates the role of other risk factors on the pathophysiology of CVT compared to truncal or central venous line (CVL) VTs in adult ALL patients

External and internal irradiation of a Rural Bryansk (Russia) population from 1990 to 2000, following high deposition of radioactive caesium from the chernobyl accident.

In 1990, a joint Nordic-Russian project was initiated in order to make independent estimations of the effective dose to selected groups of inhabitants in a highly contaminated area around the city of Novozybkov In the western Bryansk region of Russia. The inhabitants were living in six villages with initial contamination levels of Cs-137 between 0.9 and 2.7 MBq m(-2). Some villages had been decontaminated, others not. Both school children and adults participated in the study. The external irradiation of 100-130 inhabitants was determined during 1 month in September-October each year from 1990 to 2000 (except 1999), using individual thermoluminescent dosemeters. The body burden of (137,) (CS)-C-134 was determined by in vivo measurements in about 500 inhabitants annually from 1991 to 2000, and for a subgroup also with analysis of the (CS)-C-137 concentration in urine. The mean effective dose (E) from external and internal irradiation due to Cs-137,Cs- 134 deposition varied between 2.5 and 1.2 mSv per year between 1990 and 2000. The total mean E decreased, on average, by 9% per year, while the mean external dose decreased by 16% per year. The dose rate from internal radiation decreased more slowly than the dose rate from external radiation, and also showed an irregular time variation. The contribution from the internal dose to the total E was 30-50%, depending on the village. Predictions for the long-term changes in the effective dose to people living in the areas are presented. The cumulated E for the 70 years following the accident was estimated to be about 90 mSv with the assumption that both internal and external dose decrease by 2% per year after year 2000. The highest E during a life-time received by single individuals living in the area may amount to around 500 mSv considering the individual variations in E