205 research outputs found
D-dimer testing, with gender-specific cutoff levels, is of value to assess the individual risk of venous thromboembolic recurrence in non-elderly patients of both genders: a post hoc analysis of the DULCIS study
Male patients, especially the young, are at a higher risk of recurrent venous thromboembolism (RVTE) than females. Recent scientific reports show the use of D-dimer does not help predict RVTE risk in males. In the present report, we reviewed the data obtained in the DULCIS study (main report published in Blood 2014), focusing on D-dimer results recorded in non-elderly patients of both genders included in the study, and their relationship with RVTE events occurring during follow-up. Using specifically designed cutoff values for positive/negative interpretation, serial D-dimer measurements (performed during warfarin treatment and up to 3 months after discontinuation of anticoagulation) in 475 patients (males 57.3%) aged 64 65 years were obtained. D-dimer resulted positive in 46.3% and 30.5% of males and females, respectively (p = 0.001). Following management procedure, anticoagulation was stopped in 53.7% of males and 69.5% of females, who had persistently negative D-dimer results. The rate of subsequent recurrent events was 1.7% (95% CI 0.5\u20134.5%) and 0.4% (95% CI 0\u20132.5%) patient-years in males and females, respectively, with upper limits of confidence intervals always below the level of risk considered acceptable by international scientific societies for stopping anticoagulation (< 5%). In conclusion, using sensitive quantitative assays with specifically designed cutoff values and serial measurements during and after discontinuation of anticoagulation, D-dimer testing is useful to predict the risk of RVTE and is of help in deciding the duration of anticoagulation in both male and female adult patients aged up to 65 years
Euclid: Cosmological forecasts from the void size function
The Euclid mission with its spectroscopic galaxy survey covering a sky area over in the redshift range will provide a sample of tens of thousands of cosmic voids. This paper explores for the first time the constraining power of the void size function on the properties of dark energy (DE) from a survey mock catalogue, the official Euclid Flagship simulation. We identify voids in the Flagship light-cone, which closely matches the features of the upcoming Euclid spectroscopic data set. We model the void size function considering a state-of-the art methodology: we rely on the volume conserving (Vdn) model, a modification of the popular Sheth & van de Weygaert model for void number counts, extended by means of a linear function of the large-scale galaxy bias. We find an excellent agreement between model predictions and measured mock void number counts. We compute updated forecasts for the Euclid mission on DE from the void size function and provide reliable void number estimates to serve as a basis for further forecasts of cosmological applications using voids. We analyse two different cosmological models for DE: the first described by a constant DE equation of state parameter, , and the second by a dynamic equation of state with coefficients and . We forecast errors on lower than the , and we estimate an expected figure of merit (FoM) for the dynamical DE scenario when considering only the neutrino mass as additional free parameter of the model. The analysis is based on conservative assumptions to ensure full robustness, and is a pathfinder for future enhancements of the technique. Our results showcase the impressive constraining power of the void size function from the Euclid spectroscopic sample, both as a stand-alone probe, and to be combined with other Euclid cosmological probes...
Euclid preparation. XXIV. Calibration of the halo mass function in CDM cosmologies
Euclid's photometric galaxy cluster survey has the potential to be a very
competitive cosmological probe. The main cosmological probe with observations
of clusters is their number count, within which the halo mass function (HMF) is
a key theoretical quantity. We present a new calibration of the analytic HMF,
at the level of accuracy and precision required for the uncertainty in this
quantity to be subdominant with respect to other sources of uncertainty in
recovering cosmological parameters from Euclid cluster counts. Our model is
calibrated against a suite of N-body simulations using a Bayesian approach
taking into account systematic errors arising from numerical effects in the
simulation. First, we test the convergence of HMF predictions from different
N-body codes, by using initial conditions generated with different orders of
Lagrangian Perturbation theory, and adopting different simulation box sizes and
mass resolution. Then, we quantify the effect of using different halo-finder
algorithms, and how the resulting differences propagate to the cosmological
constraints. In order to trace the violation of universality in the HMF, we
also analyse simulations based on initial conditions characterised by
scale-free power spectra with different spectral indexes, assuming both
Einstein--de Sitter and standard CDM expansion histories. Based on
these results, we construct a fitting function for the HMF that we demonstrate
to be sub-percent accurate in reproducing results from 9 different variants of
the CDM model including massive neutrinos cosmologies. The calibration
systematic uncertainty is largely sub-dominant with respect to the expected
precision of future mass-observation relations; with the only notable exception
of the effect due to the halo finder, that could lead to biased cosmological
inference.Comment: 24 pages, 21 figures, 5 tables, 3 appendixes
Euclid preparation: XXVI. the Euclid Morphology Challenge: Towards structural parameters for billions of galaxies
The various Euclid imaging surveys will become a reference for studies of galaxy morphology by delivering imaging over an unprecedented area of 15 000 square degrees with high spatial resolution. In order to understand the capabilities of measuring morphologies from Euclid-detected galaxies and to help implement measurements in the pipeline of the Organisational Unit MER of the Euclid Science Ground Segment, we have conducted the Euclid Morphology Challenge, which we present in two papers. While the companion paper focusses on the analysis of photometry, this paper assesses the accuracy of the parametric galaxy morphology measurements in imaging predicted from within the Euclid Wide Survey. We evaluate the performance of five state-of-the-art surface-brightness-fitting codes, DeepLeGATo, Galapagos-2, Morfometryka, ProFit and SourceXtractor++, on a sample of about 1.5 million simulated galaxies (350 000 above 5σ) resembling reduced observations with the Euclid VIS and NIR instruments. The simulations include analytic Sérsic profiles with one and two components, as well as more realistic galaxies generated with neural networks. We find that, despite some code-specific differences, all methods tend to achieve reliable structural measurements (< 10% scatter on ideal Sérsic simulations) down to an apparent magnitude of about IE = 23 in one component and IE = 21 in two components, which correspond to a signal-to-noise ratio of approximately 1 and 5, respectively. We also show that when tested on non-analytic profiles, the results are typically degraded by a factor of 3, driven by systematics. We conclude that the official Euclid Data Releases will deliver robust structural parameters for at least 400 million galaxies in the Euclid Wide Survey by the end of the mission. We find that a key factor for explaining the different behaviour of the codes at the faint end is the set of adopted priors for the various structural parameters
Euclid preparation. XXV. The Euclid Morphology Challenge -- Towards model-fitting photometry for billions of galaxies
The ESA Euclid mission will provide high-quality imaging for about 1.5
billion galaxies. A software pipeline to automatically process and analyse such
a huge amount of data in real time is being developed by the Science Ground
Segment of the Euclid Consortium; this pipeline will include a model-fitting
algorithm, which will provide photometric and morphological estimates of
paramount importance for the core science goals of the mission and for legacy
science. The Euclid Morphology Challenge is a comparative investigation of the
performance of five model-fitting software packages on simulated Euclid data,
aimed at providing the baseline to identify the best suited algorithm to be
implemented in the pipeline. In this paper we describe the simulated data set,
and we discuss the photometry results. A companion paper (Euclid Collaboration:
Bretonni\`ere et al. 2022) is focused on the structural and morphological
estimates. We created mock Euclid images simulating five fields of view of 0.48
deg2 each in the band of the VIS instrument, each with three realisations
of galaxy profiles (single and double S\'ersic, and 'realistic' profiles
obtained with a neural network); for one of the fields in the double S\'ersic
realisation, we also simulated images for the three near-infrared ,
and bands of the NISP-P instrument, and five Rubin/LSST optical
complementary bands (, , , , and ). To analyse the results we
created diagnostic plots and defined ad-hoc metrics. Five model-fitting
software packages (DeepLeGATo, Galapagos-2, Morfometryka, ProFit, and
SourceXtractor++) were compared, all typically providing good results. (cut)Comment: 29 pages, 33 figures. Euclid pre-launch key paper. Companion paper:
Bretonniere et al. 202
Euclid preparation XXVI. The Euclid Morphology Challenge. Towards structural parameters for billions of galaxies
The various Euclid imaging surveys will become a reference for studies of
galaxy morphology by delivering imaging over an unprecedented area of 15 000
square degrees with high spatial resolution. In order to understand the
capabilities of measuring morphologies from Euclid-detected galaxies and to
help implement measurements in the pipeline, we have conducted the Euclid
Morphology Challenge, which we present in two papers. While the companion paper
by Merlin et al. focuses on the analysis of photometry, this paper assesses the
accuracy of the parametric galaxy morphology measurements in imaging predicted
from within the Euclid Wide Survey. We evaluate the performance of five
state-of-the-art surface-brightness-fitting codes DeepLeGATo, Galapagos-2,
Morfometryka, Profit and SourceXtractor++ on a sample of about 1.5 million
simulated galaxies resembling reduced observations with the Euclid VIS and NIR
instruments. The simulations include analytic S\'ersic profiles with one and
two components, as well as more realistic galaxies generated with neural
networks. We find that, despite some code-specific differences, all methods
tend to achieve reliable structural measurements (10% scatter on ideal S\'ersic
simulations) down to an apparent magnitude of about 23 in one component and 21
in two components, which correspond to a signal-to-noise ratio of approximately
1 and 5 respectively. We also show that when tested on non-analytic profiles,
the results are typically degraded by a factor of 3, driven by systematics. We
conclude that the Euclid official Data Releases will deliver robust structural
parameters for at least 400 million galaxies in the Euclid Wide Survey by the
end of the mission. We find that a key factor for explaining the different
behaviour of the codes at the faint end is the set of adopted priors for the
various structural parameters.Comment: Accepted by A&A. 30 pages, 23+6 figures, Euclid pre-launch key paper.
Companion paper: Euclid Collaboration XXV: Merlin et al. 2022 Minor
corrections after journal revie
Euclid preparation. TBD. Forecast impact of super-sample covariance on 3x2pt analysis with Euclid
Deviations from Gaussianity in the distribution of the fields probed by
large-scale structure surveys generate additional terms in the data covariance
matrix, increasing the uncertainties in the measurement of the cosmological
parameters. Super-sample covariance (SSC) is among the largest of these
non-Gaussian contributions, with the potential to significantly degrade
constraints on some of the parameters of the cosmological model under study --
especially for weak lensing cosmic shear. We compute and validate the impact of
SSC on the forecast uncertainties on the cosmological parameters for the Euclid
photometric survey, obtained with a Fisher matrix analysis, both considering
the Gaussian covariance alone and adding the SSC term -- computed through the
public code PySSC. The photometric probes are considered in isolation and
combined in the `32pt' analysis. We find the SSC impact to be
non-negligible -- halving the Figure of Merit of the dark energy parameters
(, ) in the 32pt case and substantially increasing the
uncertainties on , and for cosmic shear;
photometric galaxy clustering, on the other hand, is less affected due to the
lower probe response. The relative impact of SSC does not show significant
changes under variations of the redshift binning scheme, while it is smaller
for weak lensing when marginalising over the multiplicative shear bias nuisance
parameters, which also leads to poorer constraints on the cosmological
parameters. Finally, we explore how the use of prior information on the shear
and galaxy bias changes the SSC impact. Improving shear bias priors does not
have a significant impact, while galaxy bias must be calibrated to sub-percent
level to increase the Figure of Merit by the large amount needed to achieve the
value when SSC is not included.Comment: 22 pages, 13 figure
Euclid preparation. XXXI. The effect of the variations in photometric passbands on photometric-redshift accuracy
The technique of photometric redshifts has become essential for the
exploitation of multi-band extragalactic surveys. While the requirements on
photo-zs for the study of galaxy evolution mostly pertain to the precision and
to the fraction of outliers, the most stringent requirement in their use in
cosmology is on the accuracy, with a level of bias at the sub-percent level for
the Euclid cosmology mission. A separate, and challenging, calibration process
is needed to control the bias at this level of accuracy. The bias in photo-zs
has several distinct origins that may not always be easily overcome. We
identify here one source of bias linked to the spatial or time variability of
the passbands used to determine the photometric colours of galaxies. We first
quantified the effect as observed on several well-known photometric cameras,
and found in particular that, due to the properties of optical filters, the
redshifts of off-axis sources are usually overestimated. We show using simple
simulations that the detailed and complex changes in the shape can be mostly
ignored and that it is sufficient to know the mean wavelength of the passbands
of each photometric observation to correct almost exactly for this bias; the
key point is that this mean wavelength is independent of the spectral energy
distribution of the source}. We use this property to propose a correction that
can be computationally efficiently implemented in some photo-z algorithms, in
particular template-fitting. We verified that our algorithm, implemented in the
new photo-z code Phosphoros, can effectively reduce the bias in photo-zs on
real data using the CFHTLS T007 survey, with an average measured bias Delta z
over the redshift range 0.4<z<0.7 decreasing by about 0.02, specifically from
Delta z~0.04 to Delta z~0.02 around z=0.5. Our algorithm is also able to
produce corrected photometry for other applications.Comment: 19 pages, 13 figures; Accepted for publication in A&
Euclid preparation. XXXI. Performance assessment of the NISP Red-Grism through spectroscopic simulations for the Wide and Deep surveys
This work focuses on the pilot run of a simulation campaign aimed at
investigating the spectroscopic capabilities of the Euclid Near-Infrared
Spectrometer and Photometer (NISP), in terms of continuum and emission line
detection in the context of galaxy evolutionary studies. To this purpose we
constructed, emulated, and analysed the spectra of 4992 star-forming galaxies
at using the NISP pixel-level simulator. We built the
spectral library starting from public multi-wavelength galaxy catalogues, with
value-added information on spectral energy distribution (SED) fitting results,
and from Bruzual and Charlot (2003) stellar population templates. Rest-frame
optical and near-IR nebular emission lines were included using empirical and
theoretical relations. We inferred the 3.5 NISP red grism spectroscopic
detection limit of the continuum measured in the band for star-forming
galaxies with a median disk half-light radius of \ang{;;0.4} at magnitude ABmag for the Euclid Wide Survey and at ABmag for the Euclid Deep Survey. We found a very good
agreement with the red grism emission line detection limit requirement for the
Wide and Deep surveys. We characterised the effect of the galaxy shape on the
detection capability of the red grism and highlighted the degradation of the
quality of the extracted spectra as the disk size increases. In particular, we
found that the extracted emission line signal to noise ratio (SNR) drops by
45 when the disk size ranges from \ang{;;0.25} to \ang{;;1}. These
trends lead to a correlation between the emission line SNR and the stellar mass
of the galaxy and we demonstrate the effect in a stacking analysis unveiling
emission lines otherwise too faint to detect.Comment: 23 pages, 21 figure
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