How Cities Can Combat Illegal Guns and Gun Violence

Though gun violence peaked in American cities in the early 1990s, firearms are still used in more than 30 homicides per day in the U.S.One major challenge is how to stanch the flow of guns to criminals. Researchers from the School's Center for Gun Policy and Research have recently zeroed in on illegal sales by licensed dealers (the dominant means of diverting guns into illegal markets). These sales include unrecorded, "off the books" transactions and "straw purchases" in which a person unable to pass a federal background check relies on another individual for the purchase.Daniel Webster, MPH, ScD '91, Center co-director, wants to increase the accountability of gun dealers. This report outlines how to reduce illegal gun trafficking, reduce illegal gun carrying, and use technology to prevent gun violence

Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: a new tool to study mosquito and mammalian host interactions with malaria parasites.

To track malaria parasites for biological studies within the mosquito and mammalian hosts, we constructed a stably transformed clonal line of Plasmodium berghei, PbFluspo, in which sporogonic and pre-erythrocytic liver-stage parasites are autonomously fluorescent. A cassette containing the structural gene for the FACS-adapted green fluorescent protein mutant 2 (GFPmut2), expressed from the 5' and 3' flanking sequences of the circumsporozoite (CS) protein gene, was integrated and expressed at the endogenous CS locus. Recombinant parasites, which bear a wild-type copy of CS, generated highly fluorescent oocysts and sporozoites that invaded mosquito salivary glands and were transmitted normally to rodent hosts. The parasites infected cultured hepatocytes in vitro, where they developed into fluorescent pre-erythrocytic forms. Mammalian cells infected by these parasites can be separated from non-infected cells by fluorescence activated cell sorter (FACS) analysis. These fluorescent insect and mammalian stages of P. berghei should be useful for phenotypic studies in their respective hosts, as well as for identification of new genes expressed in these parasite stages

Updated Evidence and Policy Developments on Reducing Gun Violence in America

This digital update to Reducing Gun Violence in America presents new evidence and developments in the effort to address the staggering toll of gun violence in the United States.In 2013—in the wake of the tragic shooting at Sandy Hook Elementary School—Johns Hopkins University Press published Reducing Gun Violence in America, a collection of essays written by the world’s leading experts on gun violence. Updated Evidence and Policy Developments on Reducing Gun Violence in America follows up on the state of American gun violence by analyzing new data, research, and policy developments one year after Sandy Hook. Over the course of ten substantive chapter addendums, contributors bring readers up-to-date on such varied topics as mental illness, domestic violence, background checks, illegal gun sales, and personalized guns. They describe the recent policy measures that have been enacted and suggest additional approaches that may help stem the violence. An essential companion to Reducing Gun Violence in America, the reliable, empirical research and legal analysis in this e-book will help lawmakers, opinion leaders, and concerned citizens identify policy changes to address gun violence, which takes an average of more than 80 lives every day in the United States

Gambling with the Health of Others

The health and wellbeing of the public is, in part, a function of the behavior of individuals. When one individual’s behavior places another at a foreseeable and easily preventable risk of illness or injury, tort liability can play a valuable role in discouraging that conduct. This is true in the context of childhood immunization

Local Entities as Mechanisms for Global Climate Governance

This paper considers the role of local government entities as actors in global climate governance regimes. The authors review traditional state-based climate governance efforts and existing attempts to engage municipal and local actors through transnational municipal networks (TMNs). Arguing for the importance of TMNs to effective and time-sensitive climate action, the authors then show how and why TMNs are crucial to future efforts to address climate mitigation as part of multi-level, holistic plans for global climate governance

Gambling with the Health of Others

The health and wellbeing of the public is, in part, a function of the behavior of individuals. When one individual’s behavior places another at a foreseeable and easily preventable risk of illness or injury, tort liability can play a valuable role in discouraging that conduct. This is true in the context of childhood immunization

Hearing Loss in Osteogenesis Imperfecta: Characteristics and Treatment Considerations

Osteogenesis imperfecta (OI) is the most common heritable disorder of connective tissue. It is associated with fractures following relatively minor injury, blue sclerae, dentinogenesis imperfecta, increased joint mobility, short stature, and hearing loss. Structures in the otic capsule and inner ear share in the histologic features common to other skeletal tissues. OI is due to mutations involving several genes, the most commonly involved are the COL1A1 or COL1A2 genes which are responsible for the synthesis of the proalpha-1 and proalpha-2 polypeptide chains that form the type I collagen triple helix. A genotype/phenotype relationship to hearing loss has not been established in OI. Hearing loss is commonly found in OI with prevalence rates ranging from 50 to 92% in some studies. Hearing loss in OI may be conductive, mixed, or sensorineural and is more common by the second or third decade. Treatment options such as hearing aids, stapes surgery, and cochlear implants are discussed