Microorganisms’ Effects and Mechanisms in Ocular Infections: A Systematic Review

In the world, microorganisms are the main cause of eye illnesses. Common bacterial infections of the eye, if untreated, can damage the eye\u27s structures and lead to blindness and other visual impairments. The eye may get infected from the outside or as a result of bloodstream-borne germs invading the eye. Infectious bacteria can cause eye infections. Blepharitis, conjunctivitis, Listeriosis, keratitis, dacryocystitis, etc. are some of the frequent eye illnesses brought on by bacterial and fungal pathogens. The information on the variety of ocular surface microorganisms has been significantly increased by the series of genome-based methods through 16S rRNA gene-based identification. According to this research, a sufficient number of bacteria have a substantial part in the pathophysiology of eye illnesses, even though certain bacteria contribute to normal ocular processes. As a result, those with good vision can shed light on the intricacy of the ocular microflora and learn more about some visual requirements in addition to their vital contribution to the regular operation of the eye. Under these conditions, it is crucial to establish a quick, dependable, and affordable procedure that will eventually become a standard diagnostic process. In this literature review, many databases have searched, and the review has been methodically conducted to produce specific results for the hard eye infection disorders

Correlation between vitamin D and lipid profile in patients with ischemic stroke

Background: This study aimed to investigate the relationship between serum vitamin D level and lipid profile in ischemic stroke patients.Methods: 217 patients with ischemic stroke were selected for analysis between ages 45 and 80 years admitted at our hospital from January 2014 to December 2015. Measurement of serum vitamin-D concentration was made by electrochemiluminescence immunoassay. Confounding variables like diabetes, hypertension, smoking, alcohol, tobacco, BMI, CRP, S. uric acid, duration of sunlight exposure, prior history of drug intake or fracture and S. calcium were considered. 200 age and sex matched controls were taken. The source of data was questionnaires and multiple linear regression analysis and correlation analysis were used.Results: A positive correlation was seen between vitamin D and serum cholesterol, VLDL, LDL, triglycerides, cholesterol/HDL ratio and LDL/HDL ratio but inverse correlation between vitamin D and HDL.Conclusions: In ischemic stroke patients increase in vitamin D is associated with increase in atherogenic lipids

Neglected obstetric haemorrhage leading to acute kidney injury

Pregnancy related acute kidney injury takes substantial share of acute kidney injury (AKI) in India, with obstetrical haemorrhage having high morbidity and mortality. A young female had neglected obstetric haemorrhage (unrecognized intrauterine and massive intraperitoneal bleeding post caesarean, due to uterine trauma and atony) and dangerous intra-abdominal hypertension with exsanguination eventually leading to shock, multifactorial AKI, metabolic acidosis, and hyperkalemia. Intensive and aggressive management with subtotal hysterectomy, inotropes, fluid management, mechanical ventilation, tracheostomy, and hemodialysis changed the outcome. Despite odds against, neglected obstetric haemorrhage with complicated AKI, was managed successfully by emergency hysterectomy, aggressive intervention for AKI with intensive fluid, ventilatory management and daily hemodialysis. Timely identification and aggressive management of this condition and complications is pivotal in preventing complications, morbidity, and maternal mortality.

A brief study on Strebulus Asper L. -A Review

Streblus asper L. is a small tree found in tropical countries, such as India, Sri Lanka, Malaysia, the Philippines and Thailand belonging to family moraceae. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as filariasis, leprosy, toothache, diarrhea, dysentery and cancer. Research carried out using different in vitro and in vivo techniques of biological evaluation support most of these claims. This review presents the botany, chemistry, traditional uses and pharmacology of this medicinal plant

Correlation between vitamin D and lipid profile in patients with ischemic stroke

Background: This study aimed to investigate the relationship between serum vitamin D level and lipid profile in ischemic stroke patients.Methods: 217 patients with ischemic stroke were selected for analysis between ages 45 and 80 years admitted at our hospital from January 2014 to December 2015. Measurement of serum vitamin-D concentration was made by electrochemiluminescence immunoassay. Confounding variables like diabetes, hypertension, smoking, alcohol, tobacco, BMI, CRP, S. uric acid, duration of sunlight exposure, prior history of drug intake or fracture and S. calcium were considered. 200 age and sex matched controls were taken. The source of data was questionnaires and multiple linear regression analysis and correlation analysis were used.Results: A positive correlation was seen between vitamin D and serum cholesterol, VLDL, LDL, triglycerides, cholesterol/HDL ratio and LDL/HDL ratio but inverse correlation between vitamin D and HDL.Conclusions: In ischemic stroke patients increase in vitamin D is associated with increase in atherogenic lipids

Validation of a questionnaire to identify noise-induced hearing loss among drivers

Objective: To assess the validity of a questionnaire (consisting of 10 items/questions) to identify hearing loss (HL) among three-wheeler tempo and noncommercial car drivers. Materials and Methods: This was a cross-sectional study conducted in an urban area of Lucknow city. Three-wheeler tempo drivers and noncommercial car drivers were assessed for HL by audiometry. A total of 300 subjects, who fulfilled the study criteria, were selected for the interview and health assessment. The pure tone audiometry was conducted after >12 hours of the last noise exposure to avoid temporary threshold shift. Results: The percentage of respondents aged between 31 and 40 years was 36%. The highest affirmative response item was “Do you have trouble hearing in noisy background?” constituting 68% and the lowest affirmative response item was “Do you have trouble understanding the speech of women and children?” constituting 33.7%. Kappa values showed that there was significantly (<0.05) mild agreement between most of the items and the gold standard for mid and high-frequency HL. The area under the curve for low, mid, and high frequency HL was 0.76% (95% CI = 0.68–0.84), 0.69 (95% CI = 0.73–0.75), and 0.67 (95% CI = 0.62–0.73), respectively. The sensitivity and specificity were reasonable for all the definition of HL at different cutoff scores. Conclusion: A self-reported questionnaire-based approach may be used for the assessment of HL especially when audiometry is not feasible