Mascopt - A Network Optimization Library: Graph Manipulation

This report introduces a JAVA library whose objective is to provide tools for solving some network optimization problems and that may be used to write prototype software. We describe here the first step of the development which concerns algorithmic graph problems. This open source library named MASCOPT includes an implementation of a generic model of graph. This library has been designed with an object-oriented model and aims to be user friendly rather than focusing on speed of execution. We show how the model can be extended and dedicated to a user application by using simple object mechanism. We also present a basic description of the MASCOPT functionalities so that developers, who are familiar with objects, can use effectively for their own experimentations

Therapeutic applications of pretargeting

Targeted therapies, such as radioimmunotherapy (RIT), present a promising treatment option for the eradication of tumor lesions. RIT has shown promising results especially for hematologic malignancies, but the therapeutic efficacy is limited by unfavorable tumor-tobackground ratios resulting in high radiotoxicity. Pretargeting strategies can play an important role in addressing the high toxicity profile of RIT. Key to pretargeting is the concept of decoupling the targeting vehicle from the cytotoxic agent and administrating them separately. Studies have shown that this approach has the ability to enhance the therapeutic index as it can reduce side effects caused by off-target irradiation and thereby increase curative effects due to higher tolerated doses. Pretargeted RIT (PRIT) has been explored for imaging and treatment of different cancer types over the years. This review will give an overview of the various targeted therapies in which pretargeting has been applied, discussing PRIT with alpha-and beta-emitters and as part of combination therapy, plus its use in drug delivery systems

Case report: an unexpected link between partial deletion of the SHANK3 gene and Heller’s dementia infantilis, a rare subtype of autism spectrum disorder

International audienceAbstractBackgroundDeletions and mutations involving the SHANK3 gene lead to a nonspecific clinical presentation with moderate to profound intellectual disability, severely delayed or absent speech, and autism spectrum disorders (ASD).Better knowledge of the clinical spectrum of SHANK3 haploinsufficiency is useful to facilitate clinical care monitoring and to guide molecular diagnosis, essential for genetic counselling.Case presentationHere, we report a detailed clinical description of a 10-year-old girl carrying a pathogenic interstitial 22q13.3 deletion encompassing only the first 17 exons of SHANK3.The clinical features displayed by the girl strongly suggested the diagnosis of dementia infantilis, described by Heller in 1908, also known as childhood disintegrative disorder.ConclusionOur present case confirms several observations according to which regression may be part of the clinical phenotype of SHANK3 haploinsufficiency. Therefore, we think it is crucial to look for mutations in the gene SHANK3 in patients diagnosed for childhood disintegrative disorder or any developmental disorder with a regressive pattern involving social and communicative skills as well as cognitive and instinctual functions, with onset around 3 years

Arrondi aléatoire et protection des réseaux WDM

National audienceNous présentons un algorithme de calcul de chemins de secours dans un réseau optique qui offre de meilleures performances pratiques que d'autres algorithmes connus grâce à l'application d'une technique d'arrondi aléatoire

Arrondi aléatoire et protection des réseaux WDM

National audienceNous présentons un algorithme de calcul de chemins de secours dans un réseau optique qui offre de meilleures performances pratiques que d'autres algorithmes connus grâce à l'application d'une technique d'arrondi aléatoire

QUELQUES UTILISATIONS DES ARBRES EN COMBINATOIRE

ORSAY-PARIS 11-BU Sciences (914712101) / SudocSudocFranceF

On the Approximation Ratio of the MST-based Heuristic for the Energy-Efficient Broadcast Problem in Static Ad-Hoc Radio Networks

We present a new analysis of the approximation ratio of the MST-based heuristic [1] for the Minimum Energy Broadcast Problem in Ad-Hoc Radio Networks