Effect of antibiotic prophylaxis for preventing infectious complications following impacted mandibular third molar surgery. A randomized controlled trial

The objective of this study was to determine the effect of antibiotic prophylaxis in preventing postoperative infections after extraction of impacted mandibular third molars. A Parallel-group, randomized, blind, placebo-controlled trial was performed. 154 patients were randomly allocated to 2 groups; experimental (n=77) receiving 2g amoxicillin 1 hour prior to surgery and control (n=77) receiving placebo. Primary outcome was postoperative infections and secondary outcome was the need for rescue analgesia. 4.5% of patients developed postoperative infections, five patients of the control group (4 alveolar osteitis, 1 surgical site infection) and two of the experimental group (1 alveolar osteitis, 1 surgical site infection). Difference between groups was not statistically significant, RR=0.4 (95%CI 0.08-1.99, ?=0.41) NNTB=26. Rescue analgesia intake was significantly higher in the control group (41 vs 18 patients of experimental group) RR=0.49 (95%CI 0.32-0.75, ?<0.05) NNTB=3. The use of 2g amoxicillin 1 hour before surgery was not effective in significantly reducing the risk of postoperative infections from impacted mandibular third molars extraction, when compared to placebo. Nevertheless, antibiotic prophylaxis was associated with a reduced need for rescue analgesia

Primary Rosai-Dorfman disease in the maxilla; a case report and literature reviewPrimary Rosai-Dorfman disease in the maxilla; a case report and literature review

La enfermedad de Rosai-Dorfman es una enfermedad benigna, poco frecuente, de etiología desconocida, reconocida ampliamente como una histiocitosis sinusal con linfadenopatía masiva. Afecta principalmente a niños y adultos jóvenes de descendencia africana y, si bien, su tratamiento no es claro el pronóstico suele ser favorable. Presentamos una manifestación clínica rara e inusual de tumor maxilar derecho unilateral en una mujer de 59 años diagnosticada con enfermedad de Rosai-Dorfman luego de un riguroso estudio clínico, imagenológico, histológico e inmunohistoquímico. El tratamiento con corticoides sistémicos y radioterapia resultó ser exitoso en este caso, sin embargo, se requieren más estudios para comprobar su efectividad para el tratamiento de esta enfermedad.Rosai-Dorfman is a rare benign disease of unknown etiology, recognized as sinus histiocytosis with massive lymphadenopathy. It mainly affects children and young adults of African descent and although its treatment is not clear, the prognosis is usually favorable. We present a rare and unusual clinical manifestation of a unilateral right maxillary tumor in a 59-year-old woman diagnosed with Rosai-Dorfman disease after a rigorous clinical, imaging, and histological study. The treatment with systemic corticosteroids and radiotherapy for this unusual clinical manifestation turned out to be successful in this case, however, more studies are required to verify its effectiveness