Forecast of a quality indicator in academic activity using statistical methods

The paper presents the time evolution of an indicator for quality, which is related to self-evaluation of academic staff in technical faculties. The study is focused on two major issues that compose the academic activities: teaching and research activity on one side, and managerial activities on the other side. The aim of the study is to reveal the forecast of self-evaluation using statistical methods and to assess if possible, the minimum accepted value of the quality indicator

Epidemiology of Diabetic Foot Ulcers and Amputations in Romania: Results of a Cross-Sectional Quality of Life Questionnaire Based Survey

This is a post hoc analysis of quality of life in diabetic neuropathy patients in a cross-sectional survey performed in 2012 in Romania, using the Norfolk QOL-DN in which 21,756 patients with self-reported diabetes were enrolled. This current analysis aims to expand research on the diabetic foot and to provide an update on the number of foot ulcers found in Romania. Of the 21,174 patients included in this analysis, 14.85% reported a history of foot ulcers and 3.60% reported an amputation. The percentage of neuropathy patients with foot ulcers increased with age; the lowest percentage was observed in the 20-29-year age group (6.62%) and the highest in the 80-89-year age group (17.68%). The highest number of amputations was reported in the 70-79-year age group (largest group). Compared to patients without foot ulcers, those with foot ulcers had significantly higher scores for total DN and all its subdomains translating to worse QOL ( < 0.001). This analysis showed a high rate of foot ulcers and amputations in Romanian diabetic patients. It underscores the need for implementation of effective screening and educational programs

Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

Abstract BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy. RESULTS: In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P<0.001 for noninferiority) but was not superior to placebo with respect to efficacy (P=0.06 for superiority). The rates of death from cardiovascular causes, fatal or nonfatal myocardial infarction, fatal or nonfatal stroke, hospitalization for heart failure, and hospitalization for acute coronary syndrome, and the incidence of acute pancreatitis, pancreatic cancer, medullary thyroid carcinoma, and serious adverse events did not differ significantly between the two groups. CONCLUSIONS: Among patients with type 2 diabetes with or without previous cardiovascular disease, the incidence of major adverse cardiovascular events did not differ significantly between patients who received exenatide and those who received placebo. (Funded by Amylin Pharmaceuticals; EXSCEL ClinicalTrials.gov number, NCT01144338 .)

Advertising in a Context Harm Crisis

Context harm crises concern the challenges of advertising morally sound products in a context that is failing, as during COVID-19. Following Koselleck, we argue that crises interrupt the trajectory of existing social processes, thereby preventing consumers’ expected future outcomes. We propose a three-step future framing advertising strategy in response: 1) mourning a future that was lost to facilitate emotional adaption; 2) reconstructing a new future to facilitate rational action under conditions of ambivalence; and 3) establishing mythologies for future oriented identity work to facilitate the existential demands of crises. We then discuss health messaging from the perspective of future framing

Acculturation strategies of stigmatized groups: a case of Romanian immigrants in the UK

We draw on interviews with Romanian immigrants in post-Brexit UK to uncover whether and how they recognize and manage stigma during the process of acculturation. Findings illustrate how Romanian immigrants accumulate and use cultural and economic capital to manage their stigma, while access to social capital remains an elusive ideal

Consumer Timework

This article unpacks time as a cultural consumption resource and introduces the concept of consumer timework. Consumer timework refers to marketplace stakeholders’ negotiation of competing interpretations of how the past and the future relate using a wide range of consumption objects and activities. Building on the theory of temporalization, we argue that social tensions, conflicts, and breaks drive the past and the future apart in multiple incompatible ways that individuals and societies must contend. We theorize four fundamental dynamics of consumer time work in which market stakeholders engage: integrative, disintegrative, subjugatory, and emancipatory. Integrative and disintegrative consumer timework respectively harmonize and rupture the multiple temporal orientations (past, present, and future) to create shared communities or counter-communities of time through consumption. Subjugatory and emancipatory consumer timework respectively enforce and disrupt temporal hierarchies of power through consumption. We delineate these temporal dynamics using examples from extant consumer research. We conclude by establishing a future research agenda on consumer timework

Forecast of a quality indicator in academic activity using statistical methods

The paper presents the time evolution of an indicator for quality, which is related to self-evaluation of academic staff in technical faculties. The study is focused on two major issues that compose the academic activities: teaching and research activity on one side, and managerial activities on the other side. The aim of the study is to reveal the forecast of self-evaluation using statistical methods and to assess if possible, the minimum accepted value of the quality indicator