Multi-dimensional scaling of cat breeds and populations for Cornish Rex selective sweep analysis.

<p>Multi-dimensional scaling of the twelve breeds and two random bred populations.</p

Phenotype and <i>P2RY5</i> mutation in the Cornish Rex cat.

<p>a) An adult Cornish Rex with broken whiskers. b) The curly coat presentation of “Marcel” waves. c) Electropherogram representing the four bases deletion within <i>P2RY5</i> exon 5, c.250_253delTTTG, in a Cornish Rex (top) and a control domestic shorthair (bottom).</p

Signatures of selective sweep on chromosome A1 in Cornish Rex breed.

<p>a) Genome-wide <i>d_i</i> values, displaying significance of chromosome A1 in Cornish Rex tested against all other cat populations. The <i>d_i</i> value is plotted on the y axis and each autosome is shown in the X axis in alternating colors. Each dot represents one 500 Kb window. The dashed horizontal line represents the 99^th percentile of the empirical distribution of <i>d_i</i>. b) <i>d_i</i> values for each SNP on chromosome A1. c) A scan of Tajima’s D estimate along chromosome A1. Black line corresponds to Cornish Rex breed and gray lines correspond to other populations. d) A scan of nucleotide diversity along chromosome A1. Black line corresponds to Cornish Rex breed and gray lines correspond to other populations. Black block represents the 3 Mb homozygosity block detected in Cornish Rex and the dashed vertical line represents the mutation location in <i>P2RY5</i>.</p

A SNP based <i>d_i</i> in the chromosome A1 region and haplotype of Cornish Rex and control populations.

<p>The upper graph shows the <i>d_i</i> value for each SNP in the region within the 3 Mb shared haplotype across all Cornish Rex cats. Below, each SNP is represented by two alleles in two contiguous boxes. Boxes colored in red represent the major allele of Cornish Rex, while the blue color represent the minor allele. Faded color starts at the end of each boundaries of the haplotype block in the Cornish Rex samples. The first 12 lines of boxes represent the haplotype of each Cornish Rex included in the analysis, while below are all the other samples included in the analysis.</p