Characteristics of the study population, whole blood TDP and breast-milk thiamine at 12 weeks post partum ^1–6.

1<p>Median (interquartile range), all such values.</p>2<p>Days of provided thiamine mononitrate (daily 100 mg).</p>3<p>Mean and standard deviation, all such values.</p>4<p>TDP/Hb, thiamine diphosphate per hemoglobin.</p>5<p>Geometric mean (95% confidence interval), all such values.</p>6<p>Total thiamine, sum of thiamine and thiamine monophosphate (TMP).</p

Risk factors for deficient breast-milk total thiamine (<300 nmol/L; n = 26/636) and low whole blood TDP (<65 nmol/L; n = 31/636)^1–3.

1<p>Total thiamine, sum of TMP and thiamine.</p>2<p>WB TDP, whole blood thiamine diphosphate.</p>3<p>TMP, thiamine monophosphate.</p

Multivariate linear regression analysis on TDP in whole blood and thiamine, TMP, and total thiamine in breast-milk, <i>N</i> = 636^1–6.

1<p>Independent predictors are listed in the order they were entered in the forward models.</p>2<p>Indicates the increase in outcome per unit increase in risk factor.</p>3<p>WB TDP, whole blood thiamine diphosphate.</p>4<p>SR, Square root.</p>5<p>TMP, thiamine monophosphate.</p>6<p>Total thiamine, sum of thiamine and TMP.</p

Whole blood TDP and thiamine, TMP and total thiamine in breast-milk of women with a low (<63%) compared to those with a high (≥63%) TMP to total thiamine ratio ^1–3.

1<p>WB TDP, whole blood thiamine diphosphate.</p>2<p>TMP, thiamine monophosphate.</p>3<p>Total thiamine, sum of thiamine and TMP.</p

Thiamine and thiamine monophosphate (TMP) in breast-milk by quartiles of whole blood thiamine diphosphate (TDP).

<p>Thiamine and thiamine monophosphate (TMP) in breast-milk by quartiles of whole blood thiamine diphosphate (TDP).</p

Map of Tak Province

<p>The study area is shown in grey.</p

Changes in Drug Sensitivity of P. falciparum Isolates

<p>Isolates from primary infections were collected at SMRU clinics between 1996 and 2003 and assayed for sensitivity to artesunate and mefloquine, IC₅₀ geometric means given as nM/l (95% CI).</p

Drug sensitivity of <i>P. falciparum</i> isolates for artesunate (Figure 4a) and mefloquine (Figure 4b).

<p>Isolates from primary infections were collected at SMRU clinics between 1995 and 2007 and assayed for sensitivity to artesunate and mefloquine, IC₅₀ geometric means are given as nM/l with [95% CI].</p

Demographic characteristics on admission of patients enrolled in antimalarial drug efficacy trials who received MAS₃, between 1995 and 2007.

<p>Demographic characteristics on admission of patients enrolled in antimalarial drug efficacy trials who received MAS₃, between 1995 and 2007.</p

<i>Pfmdr1</i> copy number in parasite isolates collected in patients with primary uncomplicated <i>P. falciparum</i> infection.

<p><i>Pfmdr1</i> copy number in parasite isolates collected in patients with primary uncomplicated <i>P. falciparum</i> infection.</p