Levels of parathyroid hormone (A), serum calcium (B) and vitamin D (C) are shown in NC patients and controls at the indicated time points.

<p>Patients with calcification are depicted in red. Data are shown as mean ± standard error of the mean (SEM).</p

Urinary mineral ions in patients and controls at biopsy time points.

<p>Urinary mineral ions in patients and controls at biopsy time points.</p

Demographics and transplant data of patients with and without (controls) calcification.

<p>Continuous data are given as mean±SD unless otherwise stated;</p>*<p>p = 0.011.</p

Representative images of Fetuin A (A), MGP (B) and OPN (C) expression are shown (red circle).

<p>The expression of the antigens is specifically localized in the vicinity of calcified plaques in patients with calcification. A representative control image is shown for Osteopontin (D). Original magnification: (Fetuin a and MGP x40; OPN x40 and x60).</p

Urinary concentrations of OPN are shown in NC patients and control transplant patients without signs of calcification at the indicated time points.

<p>Patients with calcification are depicted in red.</p

Serum concentrations of Fetuin A (A) as well as MGP (B) are shown in NC patients (n = 31) in comparison to control transplant patients without signs of calcification (n = 27) at the indicated time points.

<p>Patients with calcification are depicted in red.</p

Urinary phosphate levels in NC patients in comparison to control transplant patients without signs of calcification at the indicated time points are shown.

<p>Patients with calcification are depicted in red.</p

Drug treatment and allograft status of patients and controls at biopsy time points.

<p>Values represent percentages.</p>*<p>p<0.05;</p>+<p>p = 0.056.</p>§<p>ARB’s: angiotensin receptor blockers; ACE-I’s: Angiotensin converting enzyme inhibitors,</p>$<p>any grade of hydronephrosis,</p>&<p>any cGrade>0 according to the BANFF classification.</p