Corticoperiosteal-skin flap in the treatment of septic pseudarthrosis of the calf. Clinical case

State University of Medicine and Pharmacy “Nicolae Testemitanu”, Department of Orthopaedics and Traumatology, Chisinau, Emergency Medicine Institute, Chisinau, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareIntroduction Vascularized bone plasty, is described in literature like a good method in treatment of nonunion. The priviledges of this method, is stimulation of osteogenesis through blood supply and initiation of consolidation where is was imposible earlier. Purpose Implimentation of the vascularized plasty method with corticoperiostealskin flap in treatment guide of septic pseudarthrosis of tibia bone. Clinical case presentation. Material and methods Clinical case: 45 y.o. male. One year after open fracture of the calf, tipe III A GustiloAnderson. Hospitalization diagnosis: pseudarthrosis of the tibia, distal third, with tibial bone defect and soft tissue defect of the ankle region. Results The case was solved using the corticoperiosteal-skin tibial perforator flap for arthrodesis of the ankle and for bone and soft tissue recovering. At 6 months after the surgery, we obtained the consolidation, at 1 year the metal plate was removed. At 1 year 5 months post op. the patient returned to work, the function of ankle was partially taken over by forefoot joint. Conclusions Vascularized corticoperiosteal-skin flap, can be a good method in treatment of septic pseudarthrosis of the tibia

Future perspective of vascularized bone allotransplantation

State University of Medicine and Pharmacy “Nicolae Testemițanu”, Laboratory of Tissue Engineering and Cellular Culture, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareIntroduction. Medical engineering, at the moment, is a step with a huge impact on organ transplantation. Promising the development of obtaining and using of extracellular matrices (ECM) can give a possibility to replace each organ or segment less-functional. Purpose. To review the data from the literature to determine and analyse protocols and methods for obtaining a functional ECM. Material and methods. The review included 170 published materials. The software Paperpile was been used for the selection of articles, with the keywords: bone allograft, extracellular matrix, decellularization protocol, and medical bioengineering. Results. Following our laboratory study based on obtaining a vascularized bone allograft, we divided all articles into categories thus obtaining clear pictures of the working direction. In this way, we obtained information about dispositive and protocols that has been helped us to start elaboration of our protocols for decellularization. Conclusions. The vascularized bone allograft is an intensely studied topic at the moment, but the methods for obtaining and conservation of composite bone graft’s extracellular matrix are not elucidated until the end