Left: time-of-flight MRA 3-D reconstruction; right: single-slice transverse view; bottom: zoom on the locations of three MCA radius estimates.

<p>Left: time-of-flight MRA 3-D reconstruction; right: single-slice transverse view; bottom: zoom on the locations of three MCA radius estimates.</p

Number of measurements (defined as either left or right MCA measurements) available per patient.

<p>Number of measurements (defined as either left or right MCA measurements) available per patient.</p

Illustration of a regression tree for a response depending on two predictors <i>x</i>₁ and <i>x</i>₂.

<p>Left: tree description of the approximation of the data using five constant values <i>c</i>_<i>i</i>, <i>i</i> = 1, …, 5; middle: geometrical depiction of the tree; right: graph of the approximating function.</p

Mean values, standard deviations, and number of measurements of the considered numerical variables which are side dependent.

<p>Mean values, standard deviations, and number of measurements of the considered numerical variables which are side dependent.</p

Correlations between predicted and measured CBF for the above four experiments.

<p>Due to cross-validation and the number of the various measurements available, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0165536#pone.0165536.t002" target="_blank">Table 2</a>, the number of data points used to learn the models vary.</p

Cohort chacteristics and distribution of healthy, hypertensive (HTN), diabetic (DM), diabetic and hypertensive (DM-HTN) subjects.

<p>Cohort chacteristics and distribution of healthy, hypertensive (HTN), diabetic (DM), diabetic and hypertensive (DM-HTN) subjects.</p

Scatter plot of the pCASL MRI CBF data versus TCD velocity.

<p>Scatter plot of the pCASL MRI CBF data versus TCD velocity.</p

pCASL MRI CBF data versus predicted CBF.

<p>From left to right and top to bottom, experiments 1 to 4, see text; corresponding relative correlations are <i>r</i> = 0.91, <i>p</i>-value = 2.2 × 10⁻¹⁶, <i>r</i> = 0.89, <i>p</i>-value = 2.2 × 10⁻¹⁶, <i>r</i> = .88, <i>p</i>-value = 2.2 × 10⁻¹⁶ and <i>r</i> = 0.41, <i>p</i>-value = 4.5 × 10⁻¹².</p

Mean values, standard deviations, and number of measurements of the considered numerical variables which are independent of side (for age, see Table 1).

<p>Mean values, standard deviations, and number of measurements of the considered numerical variables which are independent of side (for age, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0165536#pone.0165536.t001" target="_blank">Table 1</a>).</p

Characteristics of the study cohort.

<p>Data are presented as mean ± standard deviation (SD). P values were obtained by One-Way ANOVA to compare group means and using Wilcoxon Test for not normally distributed variables. The variables analyzed using Wilcoxon Test are Age, Sex, Race, Education, Hypertension, Microalbumin (urine), Cholesterol-to-HDL ratio, Triglycerides, Total number of Hypoglycemic Events, Average duration of Hypoglycemic Events, and Hematocrit, and other variables were analyzed using One-Way ANOVA. MMSE: Mini-Mental State Examination.</p