Role of Digital Libraries in E-learning

The use of sophisticated technologies such as computer and tele-communication are bringing classroom to the home and opening access to education for those who never entered or are unable to enter the portals of University. E-learning is an integrated and continuous approach to build knowledge skills of competitive through web enabled technologies. The digital libraries have got a significant role to play to assist effective e-learning process. Effective learning is having advantages in delivering the right content to the right person at the right time. The paper discusses need and importance of e- learning and the role of digital libraries in E-learning process

MR Imaging of epilepsy: Strategies for successful interpretation

The first half of this article is devoted to providing an introduction and overview for MR imaging of epilepsy. Several MR imaging epilepsy topics will be discussed in great detail in separate articles, such as hippocampal sclerosis, developmental disorders, and tunotional MR imaging. The remainder of this review will discuss strategies for successful interpretation of MR images from the seizure patiet and how to avoid potential pitfalls

Impact of NBME International Foundations of Medicine “IFOM” Examination on Students’ Academic Achievement

Purpose: To establish whether the inclusion of an external benchmarking examination [NBME׳s International Foundations of Medicine (IFOM)] as part of summative assessment in the Bachelor of Medicine and Bachelor of Surgery (MBBS) program at Gulf Medical University produced an impact on teaching and learning for academic achievement. Method: Two cohorts of students (N 120) who appeared for both IFOM Basic Science Exam and IFOM Clinical Science Exam were included in the study. Their IFOM scores were correlated statistically with the university-conducted pre-clerkship and clerkship summative assessment scores. Faculty and students’ evaluation surveys were also conducted to record perceptions of IFOM exams impact on teaching and learning. Results: A strong positive correlation between the IFOM examinations and the university examinations was observed with correlation coefficient between 0.7 and 0.9 and correlation being statistically significant p≤0.001. The faculty and student evaluation survey on the IFOM exams showed that 70% to 92% of respondents perceived that feedback from IFOM exams helped improvement of pedagogical strategies. Discussion: Performance on an external benchmarking examination such as NBME׳s IFOM correlated positively with performance on the university assessments following strategic improvements in teaching, learning and assessment methods in the curriculum. Keywords: External benchmarking examination, International Foundations of Medicin

Diagnosis and therapy of oral squamous cell carcinoma

Oral squamous cell carcinoma ranks among the top ten most common cancers worldwide. Despite the success in diagnosis and therapy during the past 30 years, oral squamous cell carcinoma still belongs to the tumor types with a very unfavorable prognosis. In an effort to identify genomic alterations with prognostic relevance, we applied the comparative genomic hybridization technique on oral squamous cell carcinoma. The tumors exhibited from five up to 47 DNA copy number alterations, indicating a considerable degree of genomic imbalance. Out of 35 tumors, 19 showed a gain of chromosome band 7p12. Genomic imbalances were investigated by hierarchical cluster analysis and clustered image mapping to investigate whether genomic profiles correlate with clinical data. Results of the present investigation show that profiling of genomic imbalances in general, and especially of the epidermal growth factor receptor (EGFR) on 7p12, may be suitable as prognostic factors. In order to identify small-molecule inhibitors for EGFR, we established a database of 531 natural compounds derived from medicinal plants used in traditional Chinese medicine. Candidate compounds were identified by correlation analysis using the Kendall τ-test of IC50 values of tumor cell lines and microarray-based EGFR mRNA expression. Further validation was performed by molecular docking studies using the AutoDock program with the crystal structure of EGFR tyrosine kinase domain as docking template. We estimate these results will be a further step toward the ultimate goal of individualized, patient-adapted tumor treatment based on tumor molecular profiling

Diagnosis and therapy of oral squamous cell carcinoma

Oral squamous cell carcinoma ranks among the top ten most common cancers worldwide. Despite the success in diagnosis and therapy during the past 30 years, oral squamous cell carcinoma still belongs to the tumor types with a very unfavorable prognosis. In an effort to identify genomic alterations with prognostic relevance, we applied the comparative genomic hybridization technique on oral squamous cell carcinoma. The tumors exhibited from five up to 47 DNA copy number alterations, indicating a considerable degree of genomic imbalance. Out of 35 tumors, 19 showed a gain of chromosome band 7p12. Genomic imbalances were investigated by hierarchical cluster analysis and clustered image mapping to investigate whether genomic profiles correlate with clinical data. Results of the present investigation show that profiling of genomic imbalances in general, and especially of the epidermal growth factor receptor (EGFR) on 7p12, may be suitable as prognostic factors. In order to identify small-molecule inhibitors for EGFR, we established a database of 531 natural compounds derived from medicinal plants used in traditional Chinese medicine. Candidate compounds were identified by correlation analysis using the Kendall τ-test of IC50 values of tumor cell lines and microarray-based EGFR mRNA expression. Further validation was performed by molecular docking studies using the AutoDock program with the crystal structure of EGFR tyrosine kinase domain as docking template. We estimate these results will be a further step toward the ultimate goal of individualized, patient-adapted tumor treatment based on tumor molecular profiling

Gamma irradiation of platinum- and palladium-related deep levels in silicon

258-262Effect of 1.1 MeV gamma irradiation has been studied on Au/n Si:Pt and Au/n Si:Pd Schottky barrier diodes. A comparison of the results from these two types of structures illustrate the influence of device processing on the type of defects formed by subsequent irradiation. Before irradiation the energy levels for Pt and Pd in n-type silicon have been observed at Ec-0.28eV, Ec-0.52eV and Ec-0.22eV  respectively. After irradiation and annealing all the energy levels due to irradiation are disappeared except Ec-0.28eV in Au/n - Si: Pt and Ec-0.22eV in Au/n - Si: Pd Schottky diodes

<i><span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:black;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">I-V, C-V</span></i><span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:black;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">and DLTS studies in Au/n-Si: Pd Schottky diodes</span>

612-615Deep Level Transient Spectroscopy (DLTS) technique has been used to study deep levels in palladium doped n-type silicon. The deep level due to Pd in n-type Si has been observed at Ec-0.22 eV with the carrier capture cross-section of 31E-16 cm2. The results are in agreement with the previous results in Pd -doped samples. Also C-V and I-V studies have been carried out in the Au/n-Si : Pd Schottky diodes.</span