Early Rehabilitation in Head Injury; Can We Improve the Outcomes?

Background: The quality of care after head injury is still very variable with a little coordination\n between different specialties. Acute care dominates, often with little regard to\n rehabilitation needs. Objectives: To improve the outcomes of all head injury admissions to hospital, including mild and\n moderate, by creating a head injury team to supervise a rehabilitation clinical\n pathway. Patients and Methods: A head injury team was established to manage the care of all non-neurosurgical\n admissions with head injury to a large teaching hospital. Apart from inpatient care, the\n team coordinates various services involved in the care of head injuries, arranged\n suitable follow-ups, supported relatives and trained healthcare staff on general wards\n in the treatment of head injured patients. Follow-up clinics at 6 weeks and 6 months\n were arranged. Results: In the first three years, the team managed the care of 812 admissions. Mean age was\n 44.3 years (SD = 24.8) and mean length of hospital stay was 6.1 days (SD = 10.9). Of\n these individuals, 674 attended for 6 month follow-up with 52.2% having a good outcome\n on Extended Glasgow outcome score. Patients and their relatives' feedbacks were\n excellent with an average score of 4.7/5 on overall satisfaction rating. Following\n presentations at national meetings and elsewhere, other centers in the United Kingdom\n are now setting up similar pathways. Conclusions: A dedicated clinical pathway and head injury team can improve the quality of care for\n all admissions with head injury and enhance the role for rehabilitation medicine input\n at an early stage

Arcanobacterium haemolyticum associated with pyothorax: case report

Arcanobacterium haemolyticum has an established role in the etiology of human pharyngitis. There are increasing reports of systemic infections caused by this organism. From India, we report the first case of Arcanobacterium haemolyticum causing pyothorax in an immunocompetent adolescent male patient. The probable mode of infection is also discussed. The role of A. hemolyticum as an animal pathogen needs further study

ORIENTAL JOURNAL OF CHEMISTRY Development and Validation of RP-HPLC Method for Simultaneous Determination of Niacin (Extended Release) and Lovastatin in Oral Solid Dosage Form

ABSTRACT A simple, precise and rapid HPLC method has been developed and validated for the estimation of Lovastatin and niacin simultaneously in combined dosage form. Chromatographic separation of the two drugs was performed on a Purospher BDSC8 column (150mm×4.6mmid, 5µm particlesize).The mobile phase used was a mixture of 0.1% v/v triethylamine (pH 5.0), containing 20 mM of ammonium acetate buffer: methanol (30:70% v/v).Detection was performed at 237nm and sharp peaks were obtained forniacin and Lovastatin at retention times of 3.2±0.01 min and.6.4±0.01 min respectively.The calibration curve was linear in the concentration range 100-700µg/ml for niacin 3-18µg/ml for Lovastatin; the correlation coefficients were 0.9991 and 0.9992, respectively. The optimized method showed good performance in terms of specificity, linearity, detection and quantitationlimits, precision and accuracy in accordance with the International Conference on Harmonization (ICH) Q2 (R1) guidelines.This assay was demonstrated to be applicable for routine quantitation of Lovastatin and niacin in tablet dosage form

Isocratic RP-HPLC Method for Simultaneous Separation and Estimation of Zofenopril and Hydrochlorthiazide in Pharmaceutical Dosage Forms

A simple, rapid, sensitive and accurate isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed and subsequently validated for the simultaneous determination of Zofenopril and Hydrochlorthiazide in combined dosage form. Chromatographic separation of the two drugs was performed on a Purospher BDS C18 column (250 mm × 4.6 mm id, 5 μm particle size). The mobile phase comprising of acetonitrile methanol: 0.02M NaH22PO4 buffer (40:20:40) was delivered at a flow rate of 1.0mL/min. The pH of the mobile phase is adjusted to 7.2 with Sodium hydroxide solution. Detection was performed at 245 nm.The separation was completed within 10 min and the retention time of hydrochlorthiazide is 4.62 and Zofenopril is 6.86 min respectively. Calibration curves were linear with R2 between 0.99-1.0 over a concentration range of 100-600 μg/ml for Zofenopril calcium and 50-300 μg/ml for hydrochlorthiazide..The developed method was successfully applied to determ

Actinomycotic Osteomyelitis of Maxilla Presenting as Oroantral Fistula: A Rare Case Report

Actinomycosis is a chronic granulomatous infection caused by Actinomyces species which may involve only soft tissue or bone or the two together. Actinomycotic osteomyelitis of maxilla is relatively rare when compared to mandible. These are normal commensals and become pathogens when they gain entry into tissue layers and bone where they establish and maintain an anaerobic environment with extensive sclerosis and fibrosis. This infection spreads contiguously, frequently ignoring tissue planes and surrounding tissues or organ. The portal of entry may be pulpal, periodontal infection, and so forth which may lead to involvement of adjacent structures as pharynx, larynx, tonsils, and paranasal sinuses and has the propensity to damage extensively. Diagnosis is often delayed and is usually based on histopathology as they are cultured in fewer cases. The chronic clinical course without regional lymphadenopathy may be essential in diagnosis. The management of actinomycotic osteomyelitis is surgical debridement of necrotic tissue combined with antibiotics for 3–6 months. The primary actinomycosis arising within the maxilla with contiguous involvement of paranasal sinus with formation of oroantral fistula is rare. Hence, we present a 50-year-old female patient with chronic sclerosing osteomyelitis of maxilla which presented as oroantral fistula with suppurative and sclerotic features

RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METOLAZONE AND RAMIPRIL IN ORAL SOLID DOSAGE FORM.

A Simple, efficient and reproducible reverse phase high performance liquid chromatographic method was developed and validated for the Simultaneous determination of metolazone (MET) and ramipril (RAM) in combined dosage form. The separation was effected on a Hypersil ODS C18 column (250 mm x 4.6 mm;5µ) using a mobile phase mixture of 30mM sodium dihydrogen phosphate buffer adjusted to pH 2.5.0 with orthophosphoric acid and acetonitrile in a ratio of 40:60 v/v at a flow rate of 1.0ml/min. The detection was made at 242 nm. The retention time of metolazone and ramipril was found to be 4.140 ± 0.007min and 7.007 ± 0.006min. Calibration curve was linear over the concentration range of 10-70 µg/ml for bothMetolazone and Ramipril.All the analytical validation parameters were determined and found in the limit as per ICH guidelines, which indicates the validity of the method. The developed method is also found to be precise, accurate, specific, robust and rapid for the simultaneous determination of Metolazone and Ramipril in tablet dosage forms

International Journal of Anatomy and Research,

Introduction: Suprarenal glands are among the most vascular organs in the body and they are richly supplied by the vasculature from the various sources. Suprarenal gland vasculature and its course characterized by the many unique features. Adrenal vascular studies are performed in order to identify benign or malignant, functioning or non-functioning lesions of the adrenal gland. However the vascular supply of adrenal gland is subject to a lot of variations and adequate knowledge of the arterial and venous vascularisation is of considerabl

Research article CHARACTER ASSOCIATION AND PATH COEFFICIENT ANALYSIS IN MAIZE (Zea mays L.)

ABSTRACT: An investigation was carried out on correlation and path analysis for 12 characters on 60 F1s obtained by crossing 20 inbred lines with three testers using line × tester mating design in maize. Sixty hybrids along with 23 parents and three standard checks were evaluated for twelve characters during rabi, 2012-13. The phenotypic character association among the yield components revealed positive association of grain yield per plant with days to maturity, plant height, ear height, ear length, ear girth, number of kernel rows per plant, number of kernels per row, 100kernel weight and shelling percentage. Grain yield per plant negatively correlated with days to 50 per cent tasseling and days to 50 per cent silking. The path coefficient analysis at phenotypic level revealed that character, 100-kernel weight (0.2863) exhibites the largest direct effect on grain yield per plant followed by number of kernels per row (0.2509) and ear girth (0.2202. Further, days to 50 per cent tasseling, days to 50 per cent silking and days to maturity recorded negative direct effect on grain yield

Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines

840-847 A series of novel 2,4,6-trisubstituted quinazoline derivatives 6 have been synthesized from anthranilic acids 1 in five steps via benzoxazinones 2, N-benzoyl benzamides 3, quinazol-4-ones 4, 4-chloroquinazolines 5. Products 6 have been screened for antibacterial and cytotoxic activity, promising compounds have been identified. </smarttagtype