Supporting Materials - Tables S1 and S2 from Aquaporin–graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

The aquaporin superfamily of hydrophobic integral membrane proteins constitutes water channels essential to the movement of water across the cell membrane, maintaining homeostatic equilibrium. During the passage of water between the extracellular and intracellular sides of the cell, aquaporins act as ultra-sensitive filters. Owing to their hydrophobic nature, aquaporins self-assemble in phospholipids. If a proper choice of lipids is made then the aquaporin biomimetic membrane can be used in the design of an artificial kidney. In combination with graphene, the aquaporin biomimetic membrane finds practical application in desalination and water recycling using mostly <i>Escherichia coli</i> AqpZ. Recently, human aquaporin 1 has emerged as an important biomarker in renal cell carcinoma. At present, the ultra-sensitive sensing of renal cell carcinoma is cumbersome. Hence, we discuss the use of epitopes from monoclonal antibodies as a probe for a point-of-care device for sensing renal cell carcinoma. This device works by immobilizing the antibody on the surface of a single-layer graphene, that is, as a microfluidic device for sensing renal cell carcinoma

Supporting Materials - Tables S1 and S2 from Aquaporin graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

Aquaporins superfamily of hydrophobic integral membrane proteins constitutes water channels essential to the movement of water across the cell membrane maintaining homeostatic equilibrium. During the passage of water between the extracellular and intracellular sides of the cell, aquaporins act as ultra-sensitive filters. Owing to their hydrophobic nature, aquaporins self-assemble in phospholipids and if a proper choice of lipids is made then the aquaporin biomimetic membrane can be used in the design of artificial kidney. In combination with graphene, aquaporin biomimetic membrane finds practical application in desalination and water recycling using mostly <i>Escherichia coli</i> AqpZ. Recently, human aquaporin 1 has emerged as an important biomarker in renal cell carcinoma. At present, the ultra-sensitive sensing of renal cell carcinoma is cumbersome and hence we are discussing usage of epitopes from monoclonal antibody as a probe for point-of-care device for sensing renal cell carcinoma by immobilizing the antibody on the surface of a single-layer graphene as a microfluidic device for sensing renal cell carcinoma which is pursued in our laboratories