Mid-Infrared Instrumentation for the European Extremely Large Telescope

MIDIR is the proposed thermal/mid-IR imager and spectrograph for the European Extremely Large Telescope (E-ELT). It will cover the wavelength range of 3 to at least 20 microns. Designed for diffraction-limited performance over the entire wavelength range, MIDIR will require an adaptive optics system; a cryogenically cooled system could offer optimal performance in the IR, and this is a critical aspect of the instrument design. We present here an overview of the project, including a discussion of MIDIR's science goals and a comparison with other infrared (IR) facilities planned in the next decade; top level requirements derived from these goals are outlined. We describe the optical and mechanical design work carried out in the context of a conceptual design study, and discuss some important issues to emerge from this work, related to the design, operation and calibration of the instrument. The impact of telescope optical design choices on the requirements for the MIDIR instrument is demonstrated.Comment: for publication in SPIE Proceedings vol. 6692, Cryogenic Optical Systems and Instrumentation XII, eds. J.B. Heaney and L.G. Burriesci, San Diego, Aug 200

Bioconversion of polyphenols and organic acids by gut microbiota of predigested Hibiscus sabdariffa L. calyces and Agave (A. tequilana Weber) fructans assessed in a dynamic in vitro model (TIM-2) of the human colon

The present work aimed at understanding gut microbiota bioconversion of phenolic compounds (PC) and organic acids in predigested Hibiscus sabdariffa (Hb) calyces and the mixture of Hb and Agave (Agave tequilana Weber) fructans (AF). With this purpose, dried Hb and Hb/AF were predigested with enzymatic treatment, and then fermented in a dynamic in vitro model of the human colon (TIM-2). After HPLC-ESI-QToF-MS analysis of samples taken at 0, 24, 48 and 72 h of fermentation, it was observed that hydroxycinnamic acids, flavanols, flavonols, and anthocyanins were mainly transformed into derivatives of hydroxyphenylpropionic, hydroxyphenylacetic and hydroxybenzoic acids. Moreover, organic acids, such as hydroxycitric and hibiscus acids, were formed along with unidentified lactones and reduced compounds. Interestingly, no differences were observed between microbial-derived metabolites formed after the fermentation of Hb and Hb/AF. In conclusion, colonic fermentation of polyphenol-rich Hb yields a wide range of microbial phenolic metabolites with potential effects on health.RMB and SGSA acknowledge to Science and Technology for Development Program (CYTED) through the Ibero-American Network of Underutilized Autonomous Foods (ALSUB-CYTED, 118RT0543). SGSA acknowledges CONACYT-Mexico for the sabbatical grant 260935. The Spanish Ministry of Science, Innovation and Universities (Project AGL2015-69986-R) is also acknowledged. This research has been made possible with the support of the Dutch Province of Limburg.Peer reviewe

Postgraduate Spotlights:Using a Community of Inquiry approach to enhance student engagement in geographical higher education

While the majority of pedagogical practice has been affected by the COVID-19 pandemic, the teaching of geographical research skills has been especially difficult with the loss of fieldwork and practical applications. Furthermore, the move to online teaching has diminished the learning communities in face-to-face classrooms. In an attempt to counteract these issues, this paper reflects on a learning activity in an undergraduate geographical research methods course, ‘Postgraduate Spotlights’ where two postgraduate researchers presented their specialist research methods followed by an interactive question-and-answer session with the undergraduates. We (as postgraduates, undergraduates and teaching staff) found that the open and critical discussion in the workshop fostered a Community of Inquiry that encouraged engagement from students stimulating their curiosity about geographical research methods. Through our discussion, we demonstrate the importance of having postgraduate researchers involved in teaching, as Graduate Teaching Assistants (GTAs) given their liminal role of researcher-learner. We also emphasise the importance of letting the students lead their own learning, building a Community of Inquiry across academic stages, and creating a constructive dialogue around geographical research methods. While the reproducibility of the workshop face-to-face remains to be seen, this article emphasises the potential for applying such an approach to stimulate free-flowing discussion and ultimately promote a Community of Inquiry

The non-Abelian Interferometer

We consider the tunneling current through a double point-contact Fabry-Perot interferometer such as used in recent experimental studies of the fractional quantum Hall plateau at filling fraction nu=5/2. We compare the predictions of several different models of the state of the electrons at this plateau: the Moore-Read, anti-Pfaffian, SU(2)_2 NAF, K=8 strong pairing, and (3,3,1) states. All of these predict the existence of charge e/4 quasiparticles, but the first three are non-Abelian while the last two are Abelian. We give explicit formulas for the scaling of charge e/2 and charge e/4 quasiparticle contributions to the current as a function of temperature, gate voltage and distance between the two point contacts for all three models. Based on these, we analyze several possible explanations of two phenomena reported for recent experiments by Willett et al., namely halving of the period of the observed resistance oscillations with rising temperature and alternation between the same two observed periods at low temperatures as the area of the interference loop is varied with a side gate. We conclude that the most likely explanation is that the observed alternation is due to switching between even and odd numbers of charge e/4 quasiparticles enclosed within the loop as a function of side gate voltage, which is a clear signature of the presence of non-Abelian anyons. However, there are important features of the data which do not have a simple explanation within this picture. We suggest further experiments which could help rule out some possible scenarios. We make the corresponding predictions for future tunneling and interference experiments at the other observed second Landau level fractional quantum Hall states.Comment: 15 pages, 1 figure; v2: additional discussions and references added; v3: clarifications and references updated; Appendix C has been removed and incorporated in arXiv:0909.1056; this paper has been given the more clear, accurate, and informative title "Interferometric signature of non-Abelian anyons" in PRB by its editor

Perfusion CT to evaluate the effect of transluminal angioplasty on cerebral perfusion in the treatment of vasospasm after subarachnoid hemorrhage

INTRODUCTION: Delayed ischemic neurologic deficits secondary to vasospasm are a major cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Treatment of vasospasm after SAH is associated with complications, and reliable techniques for evaluating effects of treatment of vasospasm in such patients are warranted. We present the use of perfusion computed tomography (PTC) to evaluate the effect of transluminal percutaneous angioplasty in a with SAH and vasospasm-induced ischemia. METHODS: Dynamic PCT with deconvolution produced maps of time-to-peak, mean transit time, regional cerebral blood flow, and regional cerebral blood volume, with a computerized automated map of the infarct and penumbra. CT scanners with quadruple detector array were used before and after angioplasty. RESULTS: Before angioplasty and intraarterial papaverine, PCT showed normal to decreased cerebral blood flow and increased cerebral blood volume and mean transit time in the middle cerebral artery territory of the left hemisphere. After angioplasty and intraarterial papaverine, PCT showed normalization of perfusion parameters. CONCLUSION: PCT can be a useful technique in monitoring angioplasty treatment effects in patients with vasospasm after SA

Changing a semantics: opportunism or courage?

The generalized models for higher-order logics introduced by Leon Henkin, and their multiple offspring over the years, have become a standard tool in many areas of logic. Even so, discussion has persisted about their technical status, and perhaps even their conceptual legitimacy. This paper gives a systematic view of generalized model techniques, discusses what they mean in mathematical and philosophical terms, and presents a few technical themes and results about their role in algebraic representation, calibrating provability, lowering complexity, understanding fixed-point logics, and achieving set-theoretic absoluteness. We also show how thinking about Henkin's approach to semantics of logical systems in this generality can yield new results, dispelling the impression of adhocness. This paper is dedicated to Leon Henkin, a deep logician who has changed the way we all work, while also being an always open, modest, and encouraging colleague and friend.Comment: 27 pages. To appear in: The life and work of Leon Henkin: Essays on his contributions (Studies in Universal Logic) eds: Manzano, M., Sain, I. and Alonso, E., 201