Power Laws in Solar Flares: Self-Organized Criticality or Turbulence?

We study the time evolution of Solar Flares activity by looking at the statistics of quiescent times $\tau_{L}$ between successive bursts. The analysis of 20 years of data reveals a power law distribution with exponent $\alpha \simeq 2.4$ which is an indication of complex dynamics with long correlation times. The observed scaling behavior is in contradiction with the Self-Organized Criticality models of Solar Flares which predict Poisson-like statistics. Chaotic models, including the destabilization of the laminar phases and subsequent restabilization due to nonlinear dynamics, are able to reproduce the power law for the quiescent times. In the case of the more realistic Shell Model of MHD turbulence we are able to reproduce all the observed distributions.Comment: 4 pages, 4 postscript figures. Submitted to Physical Review Letter

Pythia: Unsupervised generation of ambiguous textual claims from relational data

Applications such as computational fact checking and data-to-text generation exploit the relationship between relational data and natural language text. Despite promising results in these areas, state of the art solutions simply fail in managing “data-ambiguity”, i.e., the case when there are multiple interpretations of the relationship between the textual sentence and the relational data. To tackle this problem, we introduce Pythia, a system that, given a relational table D, generates textual sentences that contain factual ambiguities w.r.t. the data in D. Such sentences can then be used to train target applications in handling data-ambiguity. In this demonstration, we first show how our system generates data ambiguous sentences for a given table in an unsupervised fashion by data profiling and query generation. We then demonstrate how two existing applications benefit from Pythia’s generated sentences, improving the state-of-the-art results. The audience will interact with Pythia by changing input parameters in an interactive fashion, including the upload of their own dataset to see what data ambiguous sentences are generated for it

a multi node approach to simulate thin coastal structures in the sph context

We propose an improvement in modeling solid boundary conditions for 2D weakly-compressible Smoothed Particle Hydrodynamics (SPH) simulations for cases in which the thickness of the body is small compared to the desired particle size and the fluid surrounds the body from more than one side. Specifically, the fixed ghost particles technique developed by Marrone et al. (2011), based on interpolation nodes located within the fluid domain, is here extended to a multi-node approach. The fluid domain is thus divided into various sub-areas and an interpolation node for the considered solid particle is associated to every sub-area. Consequently, the solid particles present an array of values interpolated at different sub-areas for the same physical quantity. When a fluid particle located in a specific region interacts with a multi-node fixed ghost particle, the last assumes the field values interpolated in the reference area through the associated node. The present modeling allows to adopt a coarser spatial resolution to model the same physical problem, resulting in a reduction of the computational cost. The proposed solid boundary treatment is applied to horizontal decks and perforated wall-caisson breakwaters subjected to regular waves. In this context, an automatic hybrid diffusive formulation is introduced in order to prevent shock waves during water impacts and preserve the hydrostatic pressure. The formulation is obtained by defining a variable parameter detecting the occurrence of relevant density gradients induced by fluid impacts, resulting in an automatic switch between the two formulations

Concomitant mutations G12D and G13D on the exon 2 of the KRAS gene. Two cases of women with colon adenocarcinoma

Colorectal cancer (CRC) is rapidly increasing representing the second most frequent cause of cancer-related deaths. From a clinical-molecular standpoint the therapeutically management of CRC focuses on main alterations found in the RAS family protein, where single mutations of KRAS are considered both the hallmark and the target of this tumor. Double and concomitant alterations of KRAS are still far to be interpreted as molecular characteristics which could potentially address different and more personalized treatments for patients. Here, we firstly describe the case of two patients at different stages (pT2N0M0 and pT4cN1cM1) but similarly showing a double concurrent mutations G12D and G13D in the exon 2 of the KRAS gene, normally mutually exclusive. We also evaluated genetic testing of dihydropyrimidine dehydrogenase (DPYD) and microsatellite instability (MSI) by real-time PCR and additional molecular mutations by next generation sequencing (NGS) which resulted coherently to the progression of the disease. Accordingly, we reinterpreted and discuss the clinical history of both cases treated as single mutations of KRAS but similarly progressing towards a metastatic asset. We concluded that double mutations of KRAS cannot be interpreted as univocal genomic alterations and that they could severely impact the clinical outcome in CRC, requiring a tighter monitoring of patients throughout the time.Abstract: Colorectal cancer (CRC) is rapidly increasing representing the second most frequent cause of cancer-related deaths. From a clinical-molecular standpoint the therapeutically management of CRC focuses on main alterations found in the RAS family protein, where single mutations of KRAS are considered both the hallmark and the target of this tumor. Double and concomitant alterations of KRAS are still far to be interpreted as molecular characteristics which could potentially address different and more personalized treatments for patients. Here, we firstly describe the case of two patients at different stages (pT2N0M0 and pT4cN1cM1) but similarly showing a double concurrent mutations G12D and G13D in the exon 2 of the KRAS gene, normally mutually exclusive. We also evaluated genetic testing of dihydropyrimidine dehydrogenase (DPYD) and microsatellite instability (MSI) by real-time PCR and additional molecular mutations by next generation sequencing (NGS) which resulted coherently to the progression of the disease. Accordingly, we reinterpreted and discuss the clinical history of both cases treated as single mutations of KRAS but similarly progressing towards a metastatic asset. We concluded that double mutations of KRAS cannot be interpreted as univocal genomic alterations and that they could severely impact the clinical outcome in CRC, requiring a tighter monitoring of patients throughout the time