3 research outputs found
ΠΠ½Π°Π»ΠΈΠ·Π° Π½Π° MBC Π½Π° Π½Π°ΡΡΠ΅ΡΡΠΎ ΠΊΠΎΡΠΈΡΡΠ΅Π½ΠΈΡΠ΅ Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈ ΠΈ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈ Π²ΠΎ Π±ΠΎΠ»Π½ΠΈΡΠΊΠΈ ΡΡΠ»ΠΎΠ²ΠΈ ΠΈ ΠΏΠΎΡΡΠ°Π²ΡΠ²Π°ΡΠ΅ Π½Π° ΠΊΠΎΡΠ΅Π»Π°ΡΠΈΡΠ° ΠΏΠΎΠΌΠ΅ΡΡ Π½ΠΈΠ²Π½Π°ΡΠ° ΡΡΡΡΠΊΡΡΡΠ° ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡ
ΠΠ½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈΡΠ΅ ΠΈ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈΡΠ΅ ΠΏΡΠ΅ΡΡΡΠ°Π²ΡΠ²Π°Π°Ρ Π±ΠΈΠΎΡΠΈΠ΄ΠΈ, ΠΎΠ΄Π½ΠΎΡΠ½ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈ ΡΡΠΎ Π³ΠΈ ΡΠ½ΠΈΡΡΡΠ²Π°Π°Ρ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΈΡΠ΅ ΠΈΠ»ΠΈ Π³ΠΎ ΡΠΏΡΠ΅ΡΡΠ²Π°Π°Ρ Π½ΠΈΠ²Π½ΠΈΠΎΡ ΡΠ°ΡΡ, ΡΠ°Π·Π²ΠΎΡ ΠΈ ΡΠ°Π·ΠΌΠ½ΠΎΠΆΡΠ²Π°ΡΠ΅.
ΠΡΠ½ΠΎΠ²Π½Π°ΡΠ° ΡΠ°Π·Π»ΠΈΠΊΠ° ΠΏΠΎΠΌΠ΅ΡΡ Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈΡΠ΅ ΠΈ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈΡΠ΅ Π΅ ΡΠΎΠ° ΡΡΠΎ Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈΡΠ΅ ΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ²Π°Π°Ρ Π½Π° ΠΆΠΈΠ²ΠΎ ΡΠΊΠΈΠ²ΠΎ, ΠΎΠ΄Π½ΠΎΡΠ½ΠΎ ΡΠ΅ ΠΊΠΎΡΠΈΡΡΠ°Ρ Π·Π° ΠΏΠΎΡΡΠΈΠ³Π½ΡΠ²Π°ΡΠ΅ Π½Π° Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠ΅Π½ Π΅ΡΠ΅ΠΊΡ Π½Π° ΠΈΠ½ΡΠΈΡΠΈΡΠ°Π½Π° ΠΊΠΎΠΆΠ° ΠΈΠ»ΠΈ ΠΊΠΎΠ³Π° ΠΏΠΎΡΡΠΎΠΈ ΠΎΠΏΠ°ΡΠ½ΠΎΡΡ ΠΎΠ΄ ΠΏΠΎΡΠ°Π²Π° Π½Π° ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡΠ°, Π° Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈΡΠ΅ ΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ²Π°Π°Ρ Π·Π° ΠΎΡΡΡΡΠ°Π½ΡΠ²Π°ΡΠ΅ Π½Π° ΠΏΠ°ΡΠΎΠ³Π΅Π½ΠΈ ΠΈΠ»ΠΈ Π½Π΅ΠΏΠ°ΡΠΎΠ³Π΅Π½ΠΈ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΈ ΠΎΠ΄ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄Π½Π°ΡΠ° ΠΆΠΈΠ²ΠΎΡΠ½Π° ΠΎΠΊΠΎΠ»ΠΈΠ½Π°, ΠΎΠ΄ ΡΠ°Π·Π½ΠΈ ΠΏΡΠ΅Π΄ΠΌΠ΅ΡΠΈ ΠΈ ΠΏΡΠΈΠ±ΠΎΡ ΠΊΠΎΡ ΡΠ΅ ΠΊΠΎΡΠΈΡΡΠΈ Π²ΠΎ Π΄ΠΈΡΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ°ΡΠ° ΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ°ΡΠ°.
ΠΠ°ΠΊΠΎ ΡΠ°ΠΊΠ²ΠΈ, Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈΡΠ΅ ΠΈ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈΡΠ΅ Π½Π°ΠΎΡΠ°Π°Ρ ΡΠΈΡΠΎΠΊΠ° ΠΏΡΠΈΠΌΠ΅Π½Π° Π²ΠΎ Π±ΠΎΠ»Π½ΠΈΡΠΊΠΈΡΠ΅ ΡΡΡΠ°Π½ΠΎΠ²ΠΈ. ΠΠΌΠ΅Π½ΠΎ, ΠΈ Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈΡΠ΅ ΠΈ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈΡΠ΅ ΠΏΠΎΡΠ΅Π΄ΡΠ²Π°Π°Ρ ΡΠ°Π·Π»ΠΈΡΠ½Π° ΡΡΡΡΠΊΡΡΡΠ°, ΠΏΠ° ΡΠΏΠΎΡΠ΅Π΄ ΡΠΎΠ° ΠΈ ΡΠ°Π·Π»ΠΈΡΠ΅Π½ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·Π°ΠΌ Π½Π° Π΄Π΅ΡΡΡΠ²ΠΎ. ΠΠ²Π° Π΅ ΠΎΡΠ½ΠΎΠ²Π½Π° ΠΏΡΠΈΡΠΈΠ½Π° ΠΏΠΎΡΠ°Π΄ΠΈ ΠΊΠΎΡΠ° ΠΈΠΌΠ° ΡΠ°Π·Π»ΠΈΠΊΠ° Π²ΠΎ Π΅ΡΠΈΠΊΠ°ΡΠ½ΠΎΡΡΠ° ΠΏΠΎΠΌΠ΅ΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΠΈ ΡΠΈΠΏΠΎΠ²ΠΈ Π½Π° Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈ ΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΠΈ ΡΠΈΠΏΠΎΠ²ΠΈ Π½Π° Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈ. ΠΠ° Π΄Π° ΡΠ΅ ΠΈΠ·Π±Π΅ΡΠ΅ Π½Π°ΡΡΠΎΠΎΠ΄Π²Π΅ΡΠ½ΠΈΠΎΡ Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΠΊ, ΠΎΠ΄Π½ΠΎΡΠ½ΠΎ Π½Π°ΡΡΠΎΠΎΠ΄Π²Π΅ΡΠ½ΠΈΠΎΡ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½Ρ, Π½Π΅ΠΎΠΏΡ
ΠΎΠ΄Π½ΠΎ Π΅ Π΄Π° ΡΠ΅ Π²ΠΎΡΠΏΠΎΡΡΠ°Π²ΠΈ ΠΊΠΎΡΠ΅Π»Π°ΡΠΈΡΠ° ΠΏΠΎΠΌΠ΅ΡΡ Π½ΠΈΠ²Π½Π°ΡΠ° ΡΡΡΡΠΊΡΡΡΠ°ΡΠ° ΠΈ Π΄Π΅ΡΡΡΠ²ΠΎΡΠΎ. ΠΠ²Π° ΠΎΠ΄ Π΅Π΄Π½Π° ΡΡΡΠ°Π½Π° ΠΏΠΎΠ²Π»Π΅ΠΊΡΠ²Π° Π·Π³ΠΎΠ»Π΅ΠΌΡΠ²Π°ΡΠ΅ Π½Π° Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠ° ΠΎΠ΄ Π½ΠΈΠ²Π½Π°ΡΠ° ΡΠΏΠΎΡΡΠ΅Π±Π°, Π° ΠΎΠ΄ Π΄ΡΡΠ³Π° ΡΡΡΠ°Π½Π° ΡΠ΅ ΠΏΡΠ΅Π΄ΠΈΠ·Π²ΠΈΠΊΠ° Π½Π°ΠΌΠ°Π»ΡΠ²Π°ΡΠ΅ Π½Π° ΡΡΠΎΡΠΎΡΠΈΡΠ΅ Π·Π° Π½Π°Π±Π°Π²ΠΊΠ° Π½Π° Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈ ΠΈ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈ Π²ΠΎ Π±ΠΎΠ»Π½ΠΈΡΠΊΠΈΡΠ΅ ΡΡΡΠ°Π½ΠΎΠ²ΠΈ, ΡΠ°ΠΊΠ° ΡΡΠΎ Π½Π°Π±Π°Π²ΠΊΠ°ΡΠ° ΡΠ΅ ΠΎΠ³ΡΠ°Π½ΠΈΡΡΠ²Π° ΡΠ°ΠΌΠΎ Π½Π° ΠΎΠ½ΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅ΠΏΡΠΈΡΠΈ ΠΈ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΠ΅Π½ΡΠΈ ΠΊΠΎΠΈ ΡΠΎ ΡΠΈΠ³ΡΡΠ½ΠΎΡΡ Π±ΠΈ ΠΏΠΎΠΊΠ°ΠΆΠ°Π»Π΅ Π±ΠΈΠΎΡΠΈΠ΄Π΅Π½ Π΅ΡΠ΅ΠΊΡ ΡΠΏΡΠ΅ΠΌΠ° ΡΠΎΠΎΠ΄Π²Π΅ΡΠ½ΠΈΠΎΡ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·Π°
Structure and physicochemical properties of antiseptics and disinfectants in relation to their activity
Antiseptics and disinfectants represent a large group of compounds that have different effects depending on the used concentration. They are substances that remove bacteria from the skin or materials and are part of the practices for infection control in hospitals.
The action of antiseptics and disinfectants is due to mutual reaction with the cell surface of the microorganisms, followed by their penetration into the cells and the influence on a certain target area. Intrahospital (inpatient, nosocomial) infections are localized or generalized infections caused by microorganisms acquired during hospitalization. Intrahospital infections also include recurrent infections acquired during other hospitalizations and other manifest infections in patients that move from one hospital to another. In fact, these infections can result from inappropriate use of antiseptics and disinfectants.The purpose of this study is to establish a correlation between the mechanism of action of antiseptics and disinfectants and their chemical structure.
This correlation may be the basis for creating an approach that will be used as prevention from the occurrence of intrahospital or nosocomial infections. The establishment of such an approach is crucial because it is necessary to know which antiseptic or disinfectant has the greatest activity against the microoriganism which is the cause of the intrahospital (nosocomial) infection
Relation between structure and activity of antiseptics and disinfectants that are used in clinics
The aim of this study was to review the usage of antiseptics and disinfectants in selected hospitals in Strumica, Ohrid, Veles, Stip, Kavadarci and Gevgelija and their usage as a suitable way for prevention of interhospital infections, which can cause serious problems in the modern medicine. The word intrahospital or nosocomial means infections that develop in hospitals or are caused by microorganisms acquired in time of the hospitalization of the sick and their clinical manifestations occur 48β72 hours the earliest from the day that the hospitalization occurred. To achieve the purpose of lowering and prevention of these infections, number of precautions and procedures are taken into practice routinely in the hospitals. The data from the annual reports for antiseptics and disinfectants such as: Bactosal, Ecosal, Dezintal, Betadine, Hydrogen peroxide, Formaldehyde and Ethanol, used on the selected departments for gynecology, surgery and transfusion, were collected. Our purpoise was to find correlation between the structure of the antiseptics and disinfectants and the range of their activity (bacteriostatic or bactericidal). Despite of their structure it seems that physical and chemical properties of the solutions used as antiseptics and disinfectants are important for their activity.
Keywords: Antiseptics, Disinfectants, Intrahospital infections, bactericidal, bacteriostatic