Formulation and In-vitro Evaluation of Famciclovir Floating Tablets by Melt Granulation Technique

701-706Famciclovir is an antiviral drug agent which undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus. Famciclovir has shorter half life, having maximum absorption in stomach and upper part of the small intestine. Due to low gastric retention time, the bioavailability of drug is low as the large portion of drug misses the absorption window. The purpose of this study was to develop a gastroretentive floating drug delivery system to prolong the gastric residence time after oral administration, at a particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. Formulations were designed using Gelucire 43/0, Geleol, and Compritol 888 ATO, hydroxypropyl methylcellulose (HPMC K100M) as release-retarding polymer. Sodium bicarbonate and Citric acid as a gas former. Swelling ability, floating behavior and drug release studies were conducted in simulated gastric fluid. The tablets showed acceptable physicochemical properties. Drug release from the tablets was dependant on the ratio and type of the polymer used in the formulation. The in-vitro drug release pattern of Famciclovir floating tablets was fitted to different kinetic models which showed highest regression for Zero order kinetics with Erosion mechanism

Host-parasite interaction associated with major mental illness

Clinical studies frequently report that patients with major mental illness such as schizophrenia and bipolar disorder have co-morbid physical conditions, suggesting that systemic alterations affecting both brain and peripheral tissues might underlie the disorders. Numerous studies have reported elevated levels of anti-Toxoplasma gondii (T. gondii) antibodies in patients with major mental illnesses, but the underlying mechanism was unclear. Using multidisciplinary epidemiological, cell biological, and gene expression profiling approaches, we report here multiple lines of evidence suggesting that a major mental illness-related susceptibility factor, Disrupted in schizophrenia (DISC1), is involved in host immune responses against T. gondii infection. Specifically, our cell biology and gene expression studies have revealed that DISC1 Leu607Phe variation, which changes DISC1 interaction with activating transcription factor 4 (ATF4), modifies gene expression patterns upon T. gondii infection. Our epidemiological data have also shown that DISC1 607 Phe/Phe genotype was associated with higher T. gondii antibody levels in sera. Although further studies are required, our study provides mechanistic insight into one of the few well-replicated serological observations in major mental illness

Host-parasite interaction associated with major mental illness

Clinical studies frequently report that patients with major mental illness such as schizophrenia and bipolar disorder have co-morbid physical conditions, suggesting that systemic alterations affecting both brain and peripheral tissues might underlie the disorders. Numerous studies have reported elevated levels of anti-Toxoplasma gondii (T. gondii) antibodies in patients with major mental illnesses, but the underlying mechanism was unclear. Using multidisciplinary epidemiological, cell biological, and gene expression profiling approaches, we report here multiple lines of evidence suggesting that a major mental illness-related susceptibility factor, Disrupted in schizophrenia (DISC1), is involved in host immune responses against T. gondii infection. Specifically, our cell biology and gene expression studies have revealed that DISC1 Leu607Phe variation, which changes DISC1 interaction with activating transcription factor 4 (ATF4), modifies gene expression patterns upon T. gondii infection. Our epidemiological data have also shown that DISC1 607 Phe/Phe genotype was associated with higher T. gondii antibody levels in sera. Although further studies are required, our study provides mechanistic insight into one of the few well-replicated serological observations in major mental illness

TEQIP - III Sponsored First International Conference on Innovations and Challenges in Computing, Analytics and Security

This book contains abstracts of the various research papers of the academic & research community presented at the International Conference on Innovations and Challenges in Computing, Analytics and Security (ICICCAS-2020). ICICCAS-2020 has served as a platform for researchers, professionals to meet and exchange ideas on computing, data analytics, and security. The conference has invited papers in seven main tracks of Data Science, Networking Technologies, Sequential, Parallel, Distributed and Cloud Computing, Advances in Software Engineering, Multimedia, Image Processing, and Embedded Systems, Security and Privacy, Special Track (IoT, Smart Technologies and Green Engineering). The Technical and Advisory Committee Members were from various countries that have rich Research and Academic experience. Conference Title: TEQIP - III Sponsored First International Conference on Innovations and Challenges in Computing, Analytics and SecurityConference Acronym: ICICCAS-2020Conference Date: 29-30 July 2020Conference Location: Pondicherry Engineering College, Puducherry – 605014, India (Virtual Mode)Conference Organizer: Department of Computer Science and Engineering, Pondicherry Engineering College, Puducherry, India.Conference Sponsor: TEQIP-III NPIU (A Unit of the Ministry of Human Resource Development, India)