DNA immunization as a technology platform for monoclonal antibody induction

To combat the threat of many emerging infectious diseases, DNA immunization offers a unique and powerful approach to the production of high-quality monoclonal antibodies (mAbs) against various pathogens. Compared with traditional protein-based immunization approaches, DNA immunization is efficient for testing novel immunogen designs, does not require the production or purification of proteins from a pathogen or the use of recombinant protein technology and is effective at generating mAbs against conformation-sensitive targets. Although significant progress in the use of DNA immunization to generate mAbs has been made over the last two decades, the literature does not contain an updated summary of this experience. The current review provides a comprehensive analysis of the literature, including our own work, describing the use of DNA immunization to produce highly functional mAbs, in particular, those against emerging infectious diseases. Critical factors such as immunogen design, delivery approach, immunization schedule, use of immune modulators and the role of final boost immunization are discussed in detail

Contributions of Albert Einstein to Earth Sciences: A review in Commemoration of the World Year of Physics

The World Year of Physics (2005) is an international celebration to commemorate the one hundredth anniversary of Einstein's "Annus Mirabilis". The United Nations has officially declared 2005 the International Year of Physics. However, the impact of Einstein's ideas was not restricted to physics. Among numerous other disciplines, Einstein also made significant and specific contributions to Earth Sciences. His geosciences-related letters, comments, and scientific articles, are dispersed, not easily accesible and are poorly known. The present review attempts to integrate them, as a tribute to Einstein in commemoration of this centenary. These contributions can be classified into three basic areas: geodynamics, geological (planetary) catastrophism and fluvial geomorphology.Comment: 17 pages, no figures, to be published in Naturwissenschafte

Instationäre Simulation der thermischen Behaglichkeitsparameter im Sommerfall mit CFD

Kongressbeitrag zur enova 2011, Fachhochschulstudiengänge Burgenland GmbH, Studienzentrum Pinkafel