Cervical plate fracture: a rare complication

In traumatic and degenerative diseases cervical fusion with anterior cervical plate are commonly used. The increase in the use of cervical plate segment level is also increased risk of developing complications. This case report shows that the increase in the use of cervical plate segment level and also the complications in cervical spinal instrumentation, short-segment cervical plate rare case reported to be broken

Evaluation of simple blood counts as inflammation markers for brain tumor patients

Aims Hemogram parameters in routine blood panels have been proposed as inflammation markers. These parameters, especially the red cell distribution width (RDW) and mean platelet volume (MPV), were evaluated as surrogate inflammatory markers in brain tumor patients. We aimed to observe RDW and MPV values of tumor patients and compare to those in healthy population. Methods We recorded white blood cell count, neutrophil count, lymphocyte count, hemoglobin, hematocrit, RDW, platelet count, and MPV of the study group at the time of diagnosis and compared to those of the control subjects. Results The RDW was significantly elevated in study group compared to that of the control subjects (p = 0.001). The MPV was significantly lower in study group than that of the control group (p = 0.01). Conclusion Decreased MPV and increased RDW were both associated with brain tumor. However, prospective studies with larger sample sizes are needed to support the results and expose MPV and RDW variations between metastatic and primary brain tumors. © 2016 Polish Neurological Societ

Spontaneous recovery of post-traumatic cerebrospinal fluid rhinorrhea following meningitis: A case report

The aim of the present report was to present the patient with an anterior cranial base fracture who developed post-traumatic cerebrospinal fluid rhinorrhea, which recovered after onset of meningitis complication. A 26-year-old male patient who had a traffic accident one week ago was sent to our clinic because of his rhinorrhea persisting for 4 days. On cranial computed tomography, fracture of the left frontal skull base and sinus walls, a fracture line on temporal bone, parenchymal bleeding in the vicinity of the frontal sinus, subarachnoidal bleeding and left temporal extradural hematoma were detected. Then he underwent sinus wall repair and extradural hematoma was drained through bifrontal craniotomy. However, rhinorrhea persisted which resulted a deterioration in consciousness and he entered into a deep somnolent state. When his symptoms of meningitis became apparent, rhinorrhea of the patient disappeared. The patient transferred in intensive care unit and re-connected to a lumbar drainage system. On cerebral magnetic resonance imaging, regression of contrast-enhanced lesions localized in the left anterotemporal and frontal and in the regions lateral to the right trigon and medial to the right thalamus and in the right posteroparietal regions was observed. Despite repair of the anterior cranial fracture and lumbar drainage, rhinorrhea may persist. Herein, development of meningitis caused disappearing of rhinorrhea symptoms without any need for surgical intervention

Unusual presentation of multiple nerve entrapment: a case report.

Cubital tunnel syndrome is the most common form of ulnar nerve entrapment and the second most common entrapment neuropathy of the upper extremity after carpal tunnel syndrome. However, bilateral compressive ulnar neuropathy is a rare condition. Electro diagnostic studies are a valid and reliable means of confirming the diagnosis

Düşük abdominal kas enduransının kronik bel ağrısına etkisi

AMAÇ: Kronik bel ağrısı olan kişilerde abdominal kas enduransının ağrı üzerine olan etkisini incelemektir. YÖNTEM ve GEREÇLER: Araştırmaya yaşları 20 ile 60 yaş arasında değişen toplam 180 olgu dahil edilmiştir. Çalışmada 3 ay ve daha uzun süredir bel ağrısı şikayeti olan 90 kişi çalışma grubunu (Grup I); bel ağrısı tanısı ve hikayesi olmayan, düzenli spor yapmayıp, sedanter yaşam tarzı olan 90 sağlıklı olgu kontrol grubunu( Grup II); oluşturmuştur. Çalışma grubunda bel ağrısı şiddeti görsel ağrı skalası (GAS) ile değerlendirilmiştir. Aktivite ve fiziksel harekete bağlı gelişen kaygı durumu Tampa Kinezyofobi ölçeği (TKÖ) ile bel ağrısından kaynaklanan günlük yaşamdaki fonksiyonel yetersizliğin derecesi Oswestry Özürlülük İndeksi (OÖİ) ile ve abdominal kas enduransı sit-ups testi ile belirlenmiştir. BULGULAR: Bel ağrısı olan grupta istirahatteki ağrı şiddeti 3,59±2,59, aktivitedeki ağrı şiddeti 6,67±2,43 ve Oswestry Özürlülük indeksi ortalama değeri 22,60±8,85 olarak bulunmuştur. Bel ağrısı olan grupta abdominal kas enduransı ile aktivitedeki ağrı şiddeti arasında negatif yönde güçlü bir ilişki bulunmuştur(p=0,000). Abdominal kas enduransı ve TKÖ açısından iki grup arasında istatistiksel olarak anlamlı bir farklılık bulunmuştur (p=0,000). SONUÇ: Abdominal kas enduransının düşük olması kronik bel ağrısının sebeplerindendir

Retrospective evaluation in spinal cord injuries: A sample at university hospital in Turkey

INTRODUCTION – OBJECTIVE: This study was carried out to evaluation the patients with Spinal Cord Injuries (SCls) who followed in last ten years in Pamukkale University Hospital. METHOD: 495 (239 female; 256 male) patients with Spinal Cord Injuries (SCls) were evaluated retrospectively. RESULTS:Their mean age was 48.28±18.94 years. They had Spinal Cord Injuries caused by trauma 320(64.4%), spinal tumors 121(24.4%) and congenital anomalies 54(10.90/0). Injury levels were recorded as follows: 158(31.9%) in the lumbar level, 145 (29.3%) in the thoracic, 115(23.2%) in the cervical, 36(7.3%) both thoracic and lumbar spine, 10(2%) both cervical and thoracic and 31(6.3) in the other levels. While 51.7%) were males and 239 (48.3%) were females. CONClUSIONS: This results show that the main reason led to Spinal Cord Injuries was trauma. That's why; education is vital in order prevent to trauma

Retrospective evaluation in spinal cord injuries: A sample at Universty Hospital in Turkey

Objective: To evaluate the patients with Spinal Cord Injuries (SCIs) seen at Pamukkale University Hospital between 2005-2013. Methodology: 489 (236 female, 253 male) patients with SCIs were evaluated retrospectively. Results: Their mean age was 48.20±18.95 years. SCIs were caused by trauma in 316(64.6%), spinal tumors in 119(24.3%) and congenital anomalies in 54(11%) patients. Injury levels were as follows: 155(31.7%) lumbar level, 144(29.4%) thoracic, 114(23.3%) cervical, 35 (7.2%) both thoracic and lumbar spine, 10(2%) both cervical and thoracic and 31(6.3%) in the other levels. Conclusion: The main reason for SCIs was trauma. Thus, public education is vital in order prevent to trauma. © 2015 Pakistan Medical Association. All right received

The importance of differential diagnosis in trigeminal neuralgia

Purpose: Trigeminal neuralgia (TN), is a disease that is located along one or more of the trigeminal nerve branch which is usually characterized by repetitive pain in the form of knife stab and is triggered by chewing and manipulation of gingiva. The initial atypical symptoms of TN pains are called pre-trigeminal neuralgia (PTN). The purpose of this study is by defining symptoms of oral PTN better, to understand the difference between PTN and odontogenic toothache and to evaluate the effectiveness of treatment of microvascular decompression (MVD) method in TN. Method: A total of 11 patients previously diagnosed with TN (4 women, 7 men; mean age: 57.72) were retrospectively reviewed. In the neurosurgery clinic Pamukkale University School of Medicine, those 11 patients were conducted MVD operation. Results: A total of 11 patients underwent MVD operation which had previously been diagnosed with TN in our clinic. Pain of 90% of patients who underwent MVD were recovered. In the 2-year follow-up of 3 patients, the 3-year follow-up of 3 patients, 1-year follow-up of 4 patients, it was seen that the pain was not repeated. Only in 1 patient, pain was recurred in the same area in the 4th year and it was decided to reoperate the patient. Discussion: Although TN is a disease can be diagnosed by any physician, especially the recognition of PTN and dentists to be knowledgeable about differential diagnosis are very important for the treatment of patients and getting rid of their pain. MVD which is heretofore known the best treatment method in TN, is a treatment method which allows the patients to get rid of their pain completely. In this study, it has been shown a painless life is provided for patients with MVD. © 2016, Ege University Press. All Rights Reserved

Temozolomide may induce cell cycle arrest by interacting with URG4/URGCP in SH-SY5Y neuroblastoma cells

Temozolomide (TMZ) is an alkylating drug used usually in glioma treatment by inducing the apoptosis in glioma cell. The aim of the study is to investigate the anticancer mechanism of TMZ in SH-SY5Y human neuroblastoma cell line. Cytotoxic effects of TMZ were determined by using XTT assay. IC50 doses in the SH-SY5Y were detected as 5 mM. Expression profiles of novel genes URG4/URGCP, CCND1, CCND2, CDK4, and BCL2 were determined by real-time PCR. The apoptotic effects of TMZ were evaluated with TUNEL method. Furthermore, effects of TMZ on colony formation and invasion were investigated in this study. It was observed that TMZ in SH-SY5Y cell line caused a significant decrease in the gene expressions of URG4/URGCP, CCND1, CCND2, CDK4, and BCL2. According to TUNEL assay results, TMZ markedly induced apoptosis in SH-SY5Y cell line. It was found that TMZ in SH-SY5Y cell line suppressed invasion and colony formation using matrigel invasion chamber and colony formation assay, respectively. To conclude, it is thought that TMZ demonstrates anticarcinogenesis activity by affecting cell cycle arrest, apoptosis, invasion, and colony formation on SH-SY5Y cells. TMZ may be an effective agent for treatment of neuroblastoma as a single or in combination with other drugs. © 2015, International Society of Oncology and BioMarkers (ISOBM)