Influences the Aeromath in the Way of Ending Births

Air pollution represents a significant health problem in the Czech Republic (CR). Originally, the most polluted region was Northern Bohemia, later Northern Moravia. These specific conditions were used to study the impact of air pollution to children in those two regions. In Northern Bohemia, the impact of the increased concentrations of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) to fetal growth was observed, expressed as intrauterine growth retardation and impact of air pollution to respiratory morbidity and neurodevelopment in children. In Northern Moravia was studied the effect of air pollution to the morbidity of preschool children; to asthma bronchiale—gene expression, children susceptibility to benzo[a]pyrene (B[a]P); to genetic damage in newborns; concentrations of PAHs in the urine of mothers and newborns, content of PAHs in human breast milk and diet

Adverse childhood experiences, childhood relationships and associated substance use and mental health in young Europeans

Background: Adverse childhood experiences (ACEs) can increase risks of health-harming behaviours and poor health throughout life. While increases in risk may be affected by resilience resources such as supportive childhood relationships, to date few studies have explored these effects. Methods: We combined data from cross-sectional ACE studies among young adults (n = 14 661) in educational institutions in 10 European countries. Nine ACE types, childhood relationships and six health outcomes (early alcohol initiation, problem alcohol use, smoking, drug use, therapy, suicide attempt) were explored. Multivariate modelling estimated relationships between ACE counts, supportive childhood relationships and health outcomes. Results: Almost half (46.2%) of participants reported ≥1 ACE and 5.6% reported ≥4 ACEs. Risks of all outcomes increased with ACE count. In individuals with ≥4 ACEs (vs. 0 ACEs), adjusted odds ratios ranged from 2.01 (95% CIs: 1.70-2.38) for smoking to 17.68 (95% CIs: 12.93-24.17) for suicide attempt. Supportive childhood relationships were independently associated with moderating risks of smoking, problem alcohol use, therapy and suicide attempt. In those with ≥4 ACEs, adjusted proportions reporting suicide attempt reduced from 23% with low supportive childhood relationships to 13% with higher support. Equivalent reductions were 25% to 20% for therapy, 23% to 17% for problem drinking and 34% to 32% for smoking. Conclusions: ACEs are strongly associated with substance use and mental illness. Harmful relationships are moderated by resilience factors such as supportive childhood relationships. Whilst ACEs continue to affect many children, better prevention measures and interventions that enhance resilience to the life-long impacts of toxic childhood stress are required

The formation of human populations in South and Central Asia

By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization’s decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages

A geometric approach to cranial sexual dimorphism in the upper palaeolithic skulls from Predmosti (Upper Palaeolithic, Czech Republic)

The recently rediscovered glass plate negatives of unique skeletal fossil material from Předmostí – their estimated ranges from 25–27 000 years but they were destroyed during World War II – were studied by means of geometric morphometrics. The aim of this study was to determine the sexual shape variability of the best preserved skulls of adult individuals, using the methods of statistical shape analysis. While the results roughly support Matiegka’s sex estimation, skull 1 (Matiegka’s female) is more similar to males. The differences between the skulls of the Předmostí specimens are “more striking” in the lateral, frontal and vertical views, whereas the inter-sexual differences affect the non-affine parts of changes in vertical, lateral and basal views in particular. The areas of the metopion, glabella, auriculare, porion, asterion, gnathion and opisthocranion landmarks present more striking variations, i.e. those with more discriminatory power. According to the computations made of the various skull distances, the male skulls are more similar to each other and the female skulls less similar. This suggests possible patrilocal behaviour on the part of the males

Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children

Objectives: To analyze the impact of polycyclic aromatic hydrocarbons (PAHs) in ambient air at the time of delivery and five years of age on cognitive development in five year old children. Materials and Methods: Two cohorts of children born in the years 2013 and 2014 from Karvina (Northern Moravia, n = 70) and Ceske Budejovice (Southern Bohemia, n = 99) were studied at the age of five years for their cognitive development related to the exposure to PAHs, determined in the ambient air as the concentration of benzo[a]pyrene (B[a]P) and OH–PAH (hydroxy-PAH) metabolites in urine of the newborns at the time of delivery. As psychological tests, the Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used. Results: Concentrations of B[a]P in the third trimester of mother’s pregnancies were 6.1 ± 4.53 ng/m3 in Karvina, and 1.19 ± 1.28 ng/m3 (p < 0.001) in Ceske Budejovice. Neither the outcome of the RCPM test nor the BG test differed between children in Karvina vs. Ceske Budejovice, or boys vs. girls. Cognitive development in five year old children was affected by the higher exposure to PM2.5 during the third trimester in girls in Karvina. Conclusions: We did not observe any significant effect of prenatal PAH exposure on psychological cognitive tests in five year old children

Variability of the Upper Palaeolithic skulls from Predmostí near Prerov (Czech Republic): craniometric comparison with recent human standards

One of the largest skeletal series of the Upper Palaeolithic period from Predmosti was destroyed during the Second World War, but the study of this material continues up to the present. The discovery of Matiegka’s original photographic documentation on glass plates [Velemınska et al., 2004. The use of recently re-discovered glass plate photo-documentation of those human fossil finds from Predmosti u Prerova destroyed during World War II. J. Nat. Mus. Nat. Hist. Ser. 173, 129–132] gives an opportunity to perform a new and detailed craniometric analysis of five adult skulls in their lateral projection. The craniometric data were analysed using specialised Craniometrics software, and the analysis included morphological and dimensional comparisons with current Central European norms. The aim of the study was not only to monitor the skull shape as a whole, but predominantly, to evaluate the size and shape of various parts of the splanchnocranium. The Upper Palaeolithic skulls are significantly longer, and male skulls are also higher than the current norms. The crania of anatomically modern humans are characterised by two general structural features: mid-lower facial retraction and neurocranial globularity. The height of the face of the Palaeolithic skulls corresponds to that of the current Central European population. The face has a markedly longer mandibular body (3–4 SD), while female mandibular rami are shorter. The skulls are further characterised by a smaller gonial angle, the increased steepness of the mandibular ramus, and the greater angle of the chin. These changes in the size and shape associated with anterior rotation of the face produce a strong protrusion of both jaws, but the sagittal inter-maxillary relationships remain unchanged. The observed facial morphology is similar to the Czech Upper Palaeolithic skulls from Dolni Vestonice. This study confirms the main diachronic changes between skulls of Upper Palaeolithic and present-day human populations