Microbiological aspects in periodontal disease and diabetes mellitus

Background and Aims. Scientists are constantly showing a high interest for the relationship between Periodontal Disease (PD) and Diabetes Mellitus (DM). PD, “the sixth complication” of DM is recognized to be a chronic gram-negative anaerobic infectious disease. This paper is aimed at reviewing and evaluating the correlations between PD and DM from a microbiological point of view. Treatment implications of PD’s management as an important component of DM care is reviewed in the light of microbiological current knowledge. Materials and Methods. Microbiological studies and clinical trials were selected from medical and dental journals, and studied thoroughly. Results. Plaque biofilm and prolonged hyperglycemia increase the risk of PD development in DM. These two features determine inflammatory reactions that end-up in tissue destruction and impaired healing responses. Few pathogens are considered highly prevalent periodontal pathogens, with destructive actions. Studies have shown that metabolic balance or lack of balance determines bacterial variations in diabetic patients with PD. Other results demonstrate the importance of microbial tests (especially PCR techniques) as indicators for healing or disease progression. Conclusions. There aren’t many studies assessing the relationship between PD and DM from microbiological points of view. In light of increasing evidence, larger interventional studies are neede

THE EVALUATION OF OBESITY-RELATED CARDIOMETABOLIC DISEASES: A SIMPLE ANTHROPOMETRIC TOOL FOR A COMPLICATED MATTER

Introduction. Anthropometric measurements are simple clinical tools that can be used for the evaluation of obesity-related cardiometabolic complications. Objective. To identify obesity-related cardiometabolic outcomes and to compare the relevance of BMI or WHtR for early diagnosis in a group of obese children and adolescents. Material and methods. The study included 174 children diagnosed with simple obesity during a three year period. Anthropometric measurements (including BMI and WHtR) and biochemical variables were analyzed. Results. 4.28% of children were overweight, 31.43% were obese and 64.29% had extreme obesity. The main cardiometabolic complication was insulin resistance (47.76%) followed by hyperinsulinism, alteration of the lipid metabolism and hypertension. All children had a WHtR ≥ 0.5. One Way ANOVA with post-hoc t-test analysis was used for the comparative evaluation of the BMI and WHtR; there were no statistic signifi cant differences between groups. Conclusion. Obesity defi ned by BMI and a WHtR ≥ 0.5 is in the majority of cases associated with adverse cardiometabolic outcomes. Both anthropometric indexes should be used as evaluation tools in medical practice, but WHtR has some important advantages

EVALUAREA COMPLICAŢIILOR CARDIO-METABOLICE ASOCIATE OBEZITĂŢII: O METODĂ ANTROPOMETRICĂ SIMPLĂ UTILIZATĂ ÎNTR-O PROBLEMĂ COMPLICATĂ

Introducere. Măsurarea indicilor somato-metrici reprezintă o metodă clinică simplă, ce poate fi utilizată pentru evaluarea complicaţiilor cardio-metabolice asociate obezităţii. Obiective. Identifi carea complicaţiilor cardio-metabolice asociate obezităţii şi evaluarea relevanţei utilizării IMC sau a raportului circumferinţă talie-înălţime pentru diagnosticul precoce al acestora, într-un grup de copii şi adolescenţi obezi. Material şi metode. Studiul a inclus 174 de copii diagnosticaţi cu obezitate primară pe o perioadă de 3 ani. Varia bilele analizate au fost: indicii antropometrici (inclusiv IMC, raportul circumferinţă talie-înălţime) şi rezultatele investigaţiilor biochimice. Rezultate. 4,28% dintre copii prezentau suprapondere, 31,43% obezitate şi 64,29% obezitate extremă. Principalele complicaţii cardio-metabolice diagnosticate au fost: insulinorezistenţa (47,76%), hiperinsulinismul, alterarea metabolismului lipidic şi hipertensiunea arterială. Toţi copiii au avut un raport circumferinţă talieînălţime ≥ 0,5. Pentru compararea celor doi indici antropometrici s-a folosit testul ANOVA unifactorial şi analiza post-hoc; nu au existat diferenţe statistic semnifi cative între loturile analizate. Concluzii. Obezitatea defi nită prin valoarea IMC şi raportul circumferinţă talie-înălţime ≥ 0,5 se asociază, în majoritatea cazurilor, cu complicaţii cardio-metabolice. În practica medicală atât IMC, cât şi WHtR ar trebui utilizaţi ca şi metode de evaluare dar, raportul circumferinţă talie-înălţime prezintă câteva avantaje importante