Synthesis of pyrazolo[4ʹ,3ʹ:5,6]pyrano[2,3-<em>d</em>]pyrimidine derivatives and their antimicrobial, antimalarial and antituberculosis evaluation

997-1005This article deals with the synthesis of a new pyrazolo[4ʹ,3ʹ:5,6]pyrano[2,3-d]pyrimidine derivatives by the reaction of 1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitriles with ethyl cyanoacetate catalyzed by triethylamine (TEA) in ethanol under reflux conditions. All the synthesized compounds have been checked for their purity by melting point and TLC, and have been characterized through various spectroscopic techniques such as 1H and 13C NMR, IR, ESI-MS and elemental analysis. All synthesized compounds have been screened for antimicrobial, antimalarial and antituberculosis activity

Green synthesis of pyrazolo[4,3-<em>d</em>]isoxazol derivatives and their antimicrobial, antimalarial and antituberculosis evaluation

1033-1041This article deals with the synthesis of new pyrazolo[4,3-d]isoxazol derivatives by utilizing 3,4-disubstituted isoxazol-5(4H)-ones and thiosemicarbazide catalyzed by triethylamine in PEG-400 under MWI at 300 W as well as under thermal heating at 90°C. All the synthesized compounds have been characterized by various spectroscopic techniques such as 1H and 13C NMR, IR, ESI-MS and elemental analysis. All the synthesized compounds have been screened for antimicrobial, antimalarial and antituberculosis activities