A modular and convergent synthetic route to supramolecular cyclic dimers based on Amidinium-Carboxylate interactions

We describe herein the optimized design and modular synthetic approach towards supramolecularly programmed monomers that can form discrete macrocyclic species of controllable size and shape through amidinium-carboxylate interactions in apolar and polar mediaFunding from MCIN (RED2018-102331-T, PID2020-116921GBI00, and TED2021-132602B-I00) and AEI (PID2020-116112RJ-I00) is gratefully acknowledged. F.A. is grateful to MCIN and Next Generation EU funding for a “Ramon-y-Cajal” fellowship (RyC2021-031538-I). I. L. M. and J.V. H. are grateful to MINECO for a FPI grant (PRE2018-085692) and to the Comunidad de Madrid for the PEJ-2021-AI/IND-22931 contract, respective