Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report

Made available in DSpace on 2019-09-12T16:56:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2001Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy. We also review current literature about this topic. Result: bone sclerosis over the metopic suture was confirmed during surgery. Bibliographical review yields previous reports on valproate teratogenicity, mainly determining metopic suture craniosynostosis. Conclusion: sodium valproate used during pregnancy can produce craniosynostosis by teratogenic effect, specially trigonocephaly (premature fusion of metopic suture)., Fac Med; Univ Sao Paulo, Area Concentracao Neurol, BR-05508 Sao Paulo, Brazil; Hosp Santa Isabel Cli

The most frequent neurologic disturbances: a contribution to the definition of topics for the programmatic content to the program of neurology in medical graduation

Made available in DSpace on 2019-09-12T16:56:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2000Introduction: Knowledge accumulation is overfilling the thematic content of medical graduation. Medical Schools must be alert to define a minimal content related with the most frequent disturbs. We intent to suggest topics for the minimal content, to the program of Neurology in medical graduation. Method: 1. To identify the places where young doctors are working outside the School Hospital (SH): we analysed the answers of the letters sent to 6415 resident - doctors (RD) in Sao Paulo's State and we made personal interview with 201 RD. 2. To verify the most frequent neuropsichiatric disturbs (ND) in the population: we made the analysis of the patient's diagnostic records in emergency room of three institutions: Municipal of Taubate-SP Municipal of Sao Jose dos Campos-SP and Faculty of Medicine of Sao Paulo Santa Caza de Misericordia. Results: 1, The RD are young and, outside the SH, they work in other emergency services.',. The mast frequent diagnosis in institutions were listed: alcoholism, cerebrovascular disease, corns, cranial trauma, dementia, dizziness, epilepsy, facial paralysis, faint, headache, hemiplegia or paraplegia, meningitis, others paralysis, periferical neuropathy and psychiatric disordes. Conclusions Those diagnostics most frequent are relevant topics of the programmatic content to the program of Neurology in medical graduation.Universidade de Taubaté (Unitau), Disciplina Neurol & Neurocirurgia, Dept Med; Univ Sao Paulo, Fac Med, Sao Paulo, Brazil; FCM, Med Acad, Sao Paulo, Brazi