Histopathological findings in the liver tissue of CsA-induced and treated groups

Control and drug control groups show normal liver architecture (Figure 3a and 3c). Liver sections treated with CsA produces marked changes like inflammation around portal triad (Triaditis) with patchy microvesicular fatty degeneration (Figure 3b). Sulphated polysaccharides treated rats (Figure 3d) show considerable reduction in the pathological changes compared to CsA-induced animals.<p><b>Copyright information:</b></p><p>Taken from "Role of sulphated polysaccharides from in Cyclosporine A-induced oxidative liver injury in rats"</p><p>http://www.biomedcentral.com/1471-2210/8/4</p><p>BMC Pharmacology 2008;8():4-4.</p><p>Published online 20 Feb 2008</p><p>PMCID:PMC2291455.</p><p></p

Role of sulphated polysaccharides from in Cyclosporine A-induced oxidative liver injury in rats-1

and Mg-ATPase: μmole of inorganic phosphorous liberated/min/mg protein. Group I – Control; Group II – CsA; Group III – Sulphated polysaccharides; Group IV – CsA+sulphated polysaccharides Comparisons are made between: a-Group I and Group II, III, IV; b-Group II and Group IV. The symbols (***), (**) and (*) represent statistical significance at < 0.001, < 0.01 and < 0.05, respectively.<p><b>Copyright information:</b></p><p>Taken from "Role of sulphated polysaccharides from in Cyclosporine A-induced oxidative liver injury in rats"</p><p>BMC Pharmacology 2008;8():4-4.</p><p>Published online 20 Feb 2008</p><p>PMCID:PMC2291455.</p><p></p

Effect of CsA and sulphated polysaccharides on hepatic oxidants production

Values are expressed as mean ± S.D. for six animals in each group. Group I – Control; Group II – CsA; Group III – Sulphated polysaccharides; Group IV – CsA+sulphated polysaccharides. Comparisons are made between: a-Group I and Groups II, III, IV; b-Group II and Group IV. The symbols (***) and (**) represent statistical significance at < 0.001 and < 0.01, respectively.<p><b>Copyright information:</b></p><p>Taken from "Role of sulphated polysaccharides from in Cyclosporine A-induced oxidative liver injury in rats"</p><p>http://www.biomedcentral.com/1471-2210/8/4</p><p>BMC Pharmacology 2008;8():4-4.</p><p>Published online 20 Feb 2008</p><p>PMCID:PMC2291455.</p><p></p