A general relativistic model for the light propagation in the gravitational field of the Solar System: the dynamical case

Modern astrometry is based on angular measurements at the micro-arcsecond level. At this accuracy a fully general relativistic treatment of the data reduction is required. This paper concludes a series of articles dedicated to the problem of relativistic light propagation, presenting the final microarcsecond version of a relativistic astrometric model which enable us to trace back the light path to its emitting source throughout the non-stationary gravity field of the moving bodies in the Solar System. The previous model is used as test-bed for numerical comparisons to the present one. Here we also test different versions of the computer code implementing the model at different levels of complexity to start exploring the best trade-off between numerical efficiency and the micro-arcsecond accuracy needed to be reached.Comment: 40 pages, 5 figures. Accepted for publication on The Astrophysical Journal. Manuscript prepared with AASLaTeX macros v.5.

Differences in telomere length between sporadic and familial cutaneous melanoma

BACKGROUND: Several pieces of evidence indicate that a complex relationship exists between constitutional telomere length (TL) and the risk of cutaneous melanoma. Although the general perception is that longer telomeres increase melanoma risk, some studies do not support this association. We hypothesise that discordant data are due to the characteristics of the studied populations. OBJECTIVES: To evaluate the association of telomere length with familial and sporadic melanoma. METHODS: TL was measured by multiplex quantitative PCR in leukocytes from 310 melanoma patients according to familial/sporadic and single/multiple cancers and 216 age-matched controls. RESULTS: Patients with sporadic melanoma were found to have shorter telomeres as compared to those with familial melanoma. In addition, shorter telomeres, while tending to reduce the risk of familial melanoma regardless of single or multiple tumors, nearly trebled the risk of single sporadic melanoma. CONCLUSIONS: This is the first time that TL has been correlated to opposite effects on melanoma risk according to the presence or absence of familial predisposition. Individual susceptibility to melanoma should be taken into account when assessing the role of TL as a risk factor. This article is protected by copyright. All rights reserved

Frontal brain asymmetries as effective parameters to assess the quality of audiovisual stimuli perception in adult and young cochlear implant users

How is music perceived by cochlear implant (CI) users? This question arises as "the next step" given the impressive performance obtained by these patients in language perception. Furthermore, how can music perception be evaluated beyond self-report rating, in order to obtain measurable data? To address this question, estimation of the frontal electroencephalographic (EEG) alpha activity imbalance, acquired through a 19-channel EEG cap, appears to be a suitable instrument to measure the approach/withdrawal (AW index) reaction to external stimuli. Specifically, a greater value of AW indicates an increased propensity to stimulus approach, and vice versa a lower one a tendency to withdraw from the stimulus. Additionally, due to prelingually and postlingually deafened pathology acquisition, children and adults, respectively, would probably differ in music perception. The aim of the present study was to investigate children and adult CI users, in unilateral (UCI) and bilateral (BCI) implantation conditions, during three experimental situations of music exposure (normal, distorted and mute). Additionally, a study of functional connectivity patterns within cerebral networks was performed to investigate functioning patterns in different experimental populations. As a general result, congruency among patterns between BCI patients and control (CTRL) subjects was seen, characterised by lowest values for the distorted condition (vs. normal and mute conditions) in the AW index and in the connectivity analysis. Additionally, the normal and distorted conditions were significantly different in CI and CTRL adults, and in CTRL children, but not in CI children. These results suggest a higher capacity of discrimination and approach motivation towards normal music in CTRL and BCI subjects, but not for UCI patients. Therefore, for perception of music CTRL and BCI participants appear more similar than UCI subjects, as estimated by measurable and not self-reported parameters

On the Use of Electrooculogram for Efficient Human Computer Interfaces

The aim of this study is to present electrooculogram signals that can be used for human computer interface efficiently. Establishing an efficient alternative channel for communication without overt speech and hand movements is important to increase the quality of life for patients suffering from Amyotrophic Lateral Sclerosis or other illnesses that prevent correct limb and facial muscular responses. We have made several experiments to compare the P300-based BCI speller and EOG-based new system. A five-letter word can be written on average in 25 seconds and in 105 seconds with the EEG-based device. Giving message such as “clean-up” could be performed in 3 seconds with the new system. The new system is more efficient than P300-based BCI system in terms of accuracy, speed, applicability, and cost efficiency. Using EOG signals, it is possible to improve the communication abilities of those patients who can move their eyes

Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles

Gold nanoparticles (AuNPs) have been explored for their use in medicine. Here, we report a sustainable, and cost-effective method to produce AuNPs using a bacterial strain such as Pseudomonas mendocina CH50 which is also known to be a polyhydroxyalkanoate (PHA) producer. A cell-free bacterial supernatant, which is typically discarded after PHA extraction, was used to produce spherical AuNPs of 3.5 ± 1.5 nm in size as determined by Transmission Electron Microscopy (TEM) analysis. The AuNPs/PHA composite coating demonstrated antibacterial activity against Staphylococcus aureus 6538P, and antiviral activity, with a 75% reduction in viral infectivity against SARS-CoV-2 pseudotype virus

Testing general relativity by micro-arcsecond global astrometry

The global astrometric observations of a GAIA-like satellite were modeled within the PPN formulation of Post-Newtonian gravitation. An extensive experimental campaign based on realistic end-to-end simulations was conducted to establish the sensitivity of global astrometry to the PPN parameter \gamma, which measures the amount of space curvature produced by unit rest mass. The results show that, with just a few thousands of relatively bright, photometrically stable, and astrometrically well behaved single stars, among the ~10^9 objects that will be observed by GAIA, \gamma can be estimated after 1 year of continuous observations with an accuracy of ~10^{-5} at the 3\sigma level. Extrapolation to the full 5-year mission of these results based on the scaling properties of the adjustment procedure utilized suggests that the accuracy of \simeq 2x10^{-7}, at the same 3\sigma level, can be reached with \~10^6 single stars, again chosen as the most astrometrically stable among the millions available in the magnitude range V=12-13. These accuracies compare quite favorably with recent findings of scalar-tensor cosmological models, which predict for \gamma a present-time deviation, |1-\gamma|, from the General Relativity value between 10^{-5} and 10^{-7}.Comment: 7 pages, 2 figures, to be published in A&

Vacuum heat treatments of titanium porous structures

Additive manufacturing (AM) of Ti-6Al-4V enables rapid fabrication of complex parts, including porous lattices which are of interest for aerospace, automotive, or biomedical applications, however currently the fatigue resistance of these materials is a critical limitation. Engineering the alloy microstructure provides a promising method for increasing fatigue strength, but conventional heat treatment procedures are known to produce atypical results for AM and porous samples, and must therefore be optimised for these materials. Using vacuum heat treatment, microstructures comparable to those observed for conventional wrought and heat treated alloys were achieved with porous AM Ti-6Al-4V. Fine lamellar microstructures were produced using sub-transus heat treatment at 920 °C, while coarse lamellar microstructures were produced using super-transus heat treatment at 1050 °C or 1200 °C. Increasing the heat treatment temperature increased the elastic modulus from 2552 ± 22 MPa to a maximum of 2968 ± 45 MPa, due to strut sintering increasing the effective strut thickness, and removal of prior β-grain orientation. Heat treatment eliminated the brittle α’ martensite phase in favour of an α + β mixture, where the phase boundaries and β-phase provide greater resistance to crack propagation. Super-transus heat treatments increased the α-lath size which typically reduces crack propagation resistance, however strut sintering reduced surface crack initiation sites, increasing the fatigue strength by 75% from 4.86 MPa for the as-built material to a maximum of 8.51 MPa after 1200 °C heat treatment. This work demonstrates that vacuum heat treatment is effective at tuning the micro- and macro-structure of porous AM Ti-6Al-4V, thereby improving the crucial fatigue resistance

Seaweed supplementation failed to affect fecal microbiota and metabolome as well as fecal iga and apparent nutrient digestibility in adult dogs

The present study investigated in dogs the dietary effects of intact seaweeds on some fecal bacterial populations and metabolites, fecal IgA and apparent total tract digestibility (ATTD). Ten healthy adult dogs were enrolled in a 5 × 5 replicated Latin square design to evaluate five dietary treatments: control diet (CD); CD + Ascophyllum nodosum; CD + Undaria pinnatifida; CD + Saccharina japonica; CD + Palmaria palmata (n replicates per treatment = 10). Seaweeds were added to food at a daily dose of 15 g/kg. The CD contained silica as a digestion marker. Each feeding period lasted 28 d, with a 7 d wash-out in between. Feces were collected at days 21 and 28 of each period for chemical and microbiological analyses. Fecal samples were collected during the last five days of each period for ATTD assessment. Dogs showed good health conditions throughout the study. The fecal chemical parameters, fecal IgA and nutrient ATTD were not influenced by algal supplementation. Similarly, microbiological analyses did not reveal any effect by seaweed ingestion. In conclusion, algal supplementation at a dose of 15 g/kg of diet failed to exert noticeable effects on the canine fecal parameters evaluated in the present study