Creation of resilient entangled states and a resource for measurement-based quantum computation with optical superlattices

We investigate how to create entangled states of ultracold atoms trapped in optical lattices by dynamically manipulating the shape of the lattice potential. We consider an additional potential (the superlattice) that allows both the splitting of each site into a double well potential, and the control of the height of potential barrier between sites. We use superlattice manipulations to perform entangling operations between neighbouring qubits encoded on the Zeeman levels of the atoms without having to perform transfers between the different vibrational states of the atoms. We show how to use superlattices to engineer many-body entangled states resilient to collective dephasing noise. Also, we present a method to realize a 2D resource for measurement-based quantum computing via Bell-pair measurements. We analyze measurement networks that allow the execution of quantum algorithms while maintaining the resilience properties of the system throughout the computation.Comment: 23 pages, 6 figures, IOP style, published in New Journal of Physics. Minor corrections/few typos remove

Fast initialization of a high-fidelity quantum register using optical superlattices

We propose a method for the fast generation of a quantum register of addressable qubits consisting of ultracold atoms stored in an optical lattice. Starting with a half filled lattice we remove every second lattice barrier by adiabatically switching on a superlattice potential which leads to a long wavelength lattice in the Mott insulator state with unit filling. The larger periodicity of the resulting lattice could make individual addressing of the atoms via an external laser feasible. We develop a Bose-Hubbard-like model for describing the dynamics of cold atoms in a lattice when doubling the lattice periodicity via the addition of a superlattice potential. The dynamics of the transition from a half filled to a commensurately filled lattice is analyzed numerically with the help of the Time Evolving Block Decimation algorithm and analytically using the Kibble-Zurek theory. We show that the time scale for the whole process, i.e. creating the half filled lattice and subsequent doubling of the lattice periodicity, is significantly faster than adiabatic direct quantum freezing of a superfluid into a Mott insulator for large lattice periods. Our method therefore provides a high fidelity quantum register of addressable qubits on a fast time scale.Comment: 22 pages, 9 figures, IOP style. Revised version to appear in NJ

Ultra-large Rydberg dimers in optical lattices

We investigate the dynamics of Rydberg electrons excited from the ground state of ultracold atoms trapped in an optical lattice. We first consider a lattice comprising an array of double-well potentials, where each double well is occupied by two ultracold atoms. We demonstrate the existence of molecular states with equilibrium distances of the order of experimentally attainable inter-well spacings and binding energies of the order of 10^3 GHz. We also consider the situation whereby ground-state atoms trapped in an optical lattice are collectively excited to Rydberg levels, such that the charge-density distributions of neighbouring atoms overlap. We compute the hopping rate and interaction matrix elements between highly-excited electrons separated by distances comparable to typical lattice spacings. Such systems have tunable interaction parameters and a temperature ~10^{-4} times smaller than the Fermi temperature, making them potentially attractive for the study and simulation of strongly correlated electronic systems.Comment: 10 pages, 6 figures, PRA format, version to be published in PR

The beliefs and attitudes of UK registered osteopaths towards chronic pain and the management of chronic pain sufferers ::a cross-sectional questionnaire based survey

Objectives: This study investigated the beliefs and attitudes of UK registered osteopaths towards chronic pain and the management of chronic pain sufferers. Methods: A cross-sectional questionnaire based survey of UK registered osteopaths was performed to test the hypothesis that osteopaths have a more biopsychosocial approach to treating and managing chronic pain patients than other healthcare professionals. Sociodemographic determinants of the participants were explored and the original HC-PAIRS and the PABS-PT used as measurement tools. They assess practitioners' attitudes and beliefs towards perceived harmfulness of physical activities for patients with cLBP and participants' knowledge of pain. International meta-analyses were performed with both measurement tools to allow comparison with other healthcare professionals. Results: UK registered osteopaths (n=216) had mean PABS-PT subscale scores of 31.37 ± 6.26 [CI95% 30.53–32.21] (biomedical) and 32.72 ± 4.29 [CI95% 32.14–33.29] (biopsychosocial). The mean HC-PAIRS total score was 45.45 ± 10.05 [CI95% 44.11–46.8]. These indicate a wide spread of beliefs and knowledge towards chronic pain with a tendency to agree that physical activity is not necessarily harmful for patients with cLBP. Post-graduate education had a significant positive effect on questionnaire results. Meta-analyses revealed that UK registered osteopaths have significantly better HC-PAIRS scores than most physiotherapy students, nurses and pharmacists, and had similar PABS-PT scores to most other healthcare professionals. Conclusions: The hypothesis of UK registered osteopaths having a more biopsychosocial approach to treating and managing chronic pain patients in comparison to other healthcare providers has been rejected. This seems in contrast to the typically claimed unique concepts of osteopathy. Nevertheless, this study supports their ability to engage with psychosocial factors of the patients' pain experience, but shows that it can be improved. This paper suggests that training is needed to increase osteopaths' expertise in knowledge of chronic pain, and their attitudes towards the management of chronic pain sufferers

Standardized on-road tests assessing fitness-to-drive in people with cognitive impairments: A systematic review.

The on-road assessment is the gold standard because of its ecological validity. Yet existing instruments are heterogeneous and little is known about their psychometric properties. This study identified existing on-road assessment instruments and extracted data on psychometric properties and usability in clinical settings. A systematic review identified studies evaluating standardized on-road evaluation instruments adapted for people with cognitive impairment. Published articles were searched on PubMed, CINHAL, PsycINFO, Web of Science, and ScienceDirect. Study quality and the level of evidence were assessed using the COSMIN checklist. The collected data were synthetized using a narrative approach. Usability was subjectively assessed for each instrument by extracting information on acceptability, access, cost, and training. The review identified 18 published studies between 1994 and 2016 that investigated 12 different on-road evaluation instruments: the Performance-Based Driving Evaluation, the Washington University Road Test, the New Haven, the Test Ride for Practical Fitness to Drive, the Rhode Island Road Test, the Sum of Manoeuvres Score, the Performance Analysis of Driving Ability, the Composite Driving Assessment Scale, the Nottingham Neurological Driving Assessment, the Driving Observation Schedule, the Record of Driving Errors, and the Western University's On-road Assessment. Participants were mainly male (64%), between 48 and 80 years old, and had a broad variety of cognitive disorders. Most instruments showed reasonable psychometric values for internal consistency, criterion validity, and reliability. However, the level of evidence was poor to support any of the instruments given the low number of studies for each. Despite the social and health consequences of decisions taken using these instruments, little is known about the value of a single evaluation and the ability of instruments to identify expected changes. None of the identified on-road evaluation instruments seem currently adapted for clinical settings targeting rehabilitation and occupational priorities rather than road security alone. PROSPERO registration number CRD42018103276

The trail making test as a screening instrument for driving performance in older drivers; a translational research.

BACKGROUND: In many countries, primary care physicians determine whether or not older drivers are fit to drive. Little, however, is known regarding the effects of cognitive decline on driving performance and the means to detect it. This study explores to what extent the trail making test (TMT) can provide indications to clinicians about their older patients' on-road driving performance in the context of cognitive decline. METHODS: This translational study was nested within a cohort study and an exploratory psychophysics study. The target population of interest was constituted of older drivers in the absence of important cognitive or physical disorders. We therefore recruited and tested 404 home-dwelling drivers, aged 70 years or more and in possession of valid drivers' licenses, who volunteered to participate in a driving refresher course. Forty-five drivers also agreed to undergo further testing at our lab. On-road driving performance was evaluated by instructors during a 45 minute validated open-road circuit. Drivers were classified as either being excellent, good, moderate, or poor depending on their score on a standardized evaluation of on-road driving performance. RESULTS: The area under the receiver operator curve for detecting poorly performing drivers was 0.668 (CI95% 0.558 to 0.778) for the TMT-A, and 0.662 (CI95% 0.542 to 0.783) for the TMT-B. TMT was related to contrast sensitivity, motion direction, orientation discrimination, working memory, verbal fluency, and literacy. Older patients with a TMT-A ≥ 54 seconds or a TMT-B ≥ 150 seconds have a threefold (CI95% 1.3 to 7.0) increased risk of performing poorly during the on-road evaluation. TMT had a sensitivity of 63.6%, a specificity of 64.9%, a positive predictive value of 9.5%, and a negative predictive value of 96.9%. CONCLUSION: In screening settings, the TMT would have clinicians uselessly consider driving cessation in nine drivers out of ten. Given the important negative impact this could have on older drivers, this study confirms the TMT not to be specific enough for clinicians to justify driving cessation without complementary investigations on driving behaviors

Comparison of the European and U.S. guidelines for lipid-lowering therapy in primary prevention of cardiovascular disease.

Population-wide impacts of new guidelines in the primary prevention of atherosclerotic cardiovascular disease (ASCVD) should be explored in independent cohorts. Assess and compare the lipid-lowering therapy eligibility and predictive classification performance of 2016 and 2021 European Society of Cardiology (ESC), 2019 American Heart Association/American College of Cardiology (AHA/ACC) and 2022U.S. Preventive Services Task Force (USPSTF) guidelines. Participants from the Colaus|PsyCoLaus study, without ASCVD and not taking lipid-lowering therapy at baseline. Derivation of 10-year risk for ASCVD using SCORE1, SCORE2 (including SCORE2-OP) and PCE. Computation of the number of people eligible for lipid-lowering therapy based on each guideline and assessment of discrimination and calibration metrics of the risk models using first incident ASCVD as an outcome. Among 4,092 individuals, 158 (3.9%) experienced an incident ASCVD during a median follow-up of 9 years (IQR, 1.1). Lipid-lowering therapy was recommended or considered in 40.2% (95% CI, 38.2-42.2), 26.4% (24.6-28.2), 28.6% (26.7-30.5) and 22.6% (20.9-24.4) of women and in 62.1% (59.8-64.3), 58.7% (56.4-61.0), 52.6% (50.3-54.9) and 48.4% (46.1-50.7) of men according to 2016 ESC, 2021 ESC, 2019 AHA/ACC and 2022 USPSTF guidelines, respectively. 43.3% and 46.7% of women facing an incident ASCVD were not eligible for lipid-lowering therapy at baseline according to 2021 ESC and 2022 USPSTF, compared to 21.7% and 38.3% using 2016 ESC and 2019 AHA/ACC, respectively. Both 2022 USPSTF and 2021 ESC guidelines particularly reduced lipid-lowering therapy eligibility in women. Nearly half of women who faced an incident ASCVD were not eligible for lipid-lowering therapy

Systematic Investigations into the Numerical Response Prediction of a Solar Array Stack under Acoustic Excitation

Satellites and payloads launched with large launch vehicles equipped with solid rocket boosters, e.g. ARIANE-5 and NSTS, will be subject to high noise levels during lift-off and atmospheric flight. Particularly sub-systems that have a large surface area and low mass can be very sensitive to acoustic excitation. Examples of such sub-systems are antenna reflectors and solar arrays. This paper presents the main results of a study that follows a systematic approach to investigate the numerical response prediction of a solar array stack, i.e. a solar array in stowed configuration, subject to acoustic excitation. The study has been carried out by Fokker Space (NL) and Metravib R.D.S. (F) under an ESA research and development contract. The hardware selected for the study has been the ARAFOM 5-panel wing. In the frame of the study, the wing has undergone a sequence of mechanical tests, namely a · modal survey test in air and in helium · shaker test with harmonic base excitation (sine test) · acoustic plane wave test · acoustic noise test Results of the modal survey and the sine test, particularly of the modal survey under helium providing a quasi-vacuum environment, have been used to correlate and update the initial mathematical finite element model of the wing. The target of this first step has been to establish a finite element model of the wing that represents as best as possible the dynamic characteristics of the the wing under vacuum conditions. The effects of the air on the dynamic response of the wing have then been modelled by a boundary element approach. This can accurately represent the fluid pressure and radiation impedance loads on the structure. A particular difficulty has been the modelling of the thin air gaps in between the individual panels of the wing. Responses of the wing to acoustic plane wave excitation have been computed and have been correlated with the responses measured from the acoustic plane wave testResponses have been evaluated in terms of structural accelerations and stresses, but also in terms of acoustic pressures in the inter panel gaps and the surrounding fluid. Eventually, the response of the wing to acoustic noise excitation has been numerically simulated using a superposition of plane acoustic waves, and the results have been correlated with the responses from the acoustic noise test