The Configuration of the Perivascular System Transporting Macromolecules in the CNS

Large blood vessels entering the CNS are surrounded by perivascular spaces that communicate with the cerebrospinal fluid and, at their termini, with the interstitial space. Solutes and particles can translocate along these perivascular conduits, reportedly in both directions. Recently, this prompted a renewed interest in the intrathecal therapy delivery route for CNS-targeted therapeutics. However, the extent of the CNS coverage by the perivascular system is unknown, making the outcome of drug administration to the CSF uncertain. We traced the translocation of model macromolecules from the CSF into the CNS of rats and non-human primates. Conduits transporting macromolecules were found to extend throughout the parenchyma from both external and internal (fissures) CNS boundaries, excluding ventricles, in large numbers, on average ca. 40 channels per mm2 in rats and non-human primates. The high density and depth of extension of the perivascular channels suggest that the perivascular route can be suitable for delivery of therapeutics to parenchymal targets throughout the CNS

Competitive Approach in Managerial Leadership Psychology

This article is devoted to the one of the managerial leadership psychology’s problem: managerial leadership abilities. There is a competitive approach’s critical review about managerial leadership in organization. According this point of view leadership’s ability is the only one special personality quality. There are empirical frameworks of managerial leadership giftedness psychological concept

Consistency of personal identity as a resource of pedagogical prevention of adolescents’ radicalization

The article discusses the problem of countering the radicalization of adolescents. It is assumed that adolescents are a social group that is subject to radical influence. This paper emphasizes the growing tendency to involve adolescents and young men in extremist and terrorist acts. Modern theoretical concepts of radicalization are considered and their specific nature is determined. It is noted that all concepts take into account the role of disturbed or difficult social relationships as a latent factor of radicalization

Psychological determinants of managerial leadership in internal affairs officers

The possibility of applying the concept of managerial leadership as a theoretical basis for building an innovative training and formation system of territorial bodies and units senior staff reserve of internal affairs bodies is discussed in the article. The results of an empirical study, the purpose of which is to identify the psychological characteristics of internal affairs officers who are prone to managerial leadership, are presented

CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder

A major challenge for the treatment of many central nervous system (CNS) disorders is the lack of convenient and effective methods for delivering biological agents to the brain. Mucopolysaccharidosis II (Hunter syndrome) is a rare inherited lysosomal storage disorder resulting from a deficiency of iduronate-2-sulfatase (I2S). I2S is a large, highly glycosylated enzyme. Intravenous administration is not likely to be an effective therapy for disease-related neurological outcomes that require enzyme access to the brain cells, in particular neurons and oligodendrocytes. We demonstrate that intracerebroventricular and lumbar intrathecal administration of recombinant I2S in dogs and nonhuman primates resulted in widespread enzyme distribution in the brain parenchyma, including remarkable deposition in the lysosomes of both neurons and oligodendrocytes. Lumbar intrathecal administration also resulted in enzyme delivery to the spinal cord, whereas little enzyme was detected there after intraventricular administration. Mucopolysaccharidosis II model is available in mice. Lumbar administration of recombinant I2S to enzyme deficient animals reduced the storage of glycosaminoglycans in both superficial and deep brain tissues, with concurrent morphological improvements. The observed patterns of enzyme transport from cerebrospinal fluid to the CNS tissues and the resultant biological activity (a) warrant further investigation of intrathecal delivery of I2S via lumbar catheter as an experimental treatment for the neurological symptoms of Hunter syndrome and (b) may have broader implications for CNS treatment with biopharmaceuticals

STABILITY OF THE CASING CONSTRUCTIONS OF THE ROCKETS WITH THE THERMOFORCE LOADING

The purpose of the work: the development of the method and digital algorithms of the design-experimental investigation of the unlinear deformation and stability of the envelopes at the asymmetrical thermoforce loading with the creeping deformation to be considered, the performance of the theoretical and experimental investigations NDS and stability of casing constructions of the rockets. The methods and the digital algorithms of solving the problems of the non-linear deformation and stability of anisotropic envelopes with the asymmetric heating and loading, the new methods of the experimental investigation of the nose cones and tanks of the rockets stability have been developed. The results of the investigations have been introduced. The field of application: rocket-building, aviabuilding, ships building, power engineering.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Psychological determinants of managerial leadership in internal affairs officers

The possibility of applying the concept of managerial leadership as a theoretical basis for building an innovative training and formation system of territorial bodies and units senior staff reserve of internal affairs bodies is discussed in the article. The results of an empirical study, the purpose of which is to identify the psychological characteristics of internal affairs officers who are prone to managerial leadership, are presented