Experimental infection of H5N1 HPAI in BALB/c mice

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Influenza (H5N1) Viruses in Poultry, Russian Federation, 2005–2006

Migrating waterfowl may be the primary source of influenza (H5N1) in western Siberia and the European part of the Russian Federation

Intranasal immunization of guinea pig with trivalent influenza antigenadjuvanted by Cyclamen europaeum tubers extract

AbstractCyclamen europaeum tubers extract (CTE) with concentration commonly used for human rhinosinusitis treatment was testedas mucosal adjuvant in experimental intranasal immunization of guinea pigs with concentrated commercially availableinfluenza trivalent vaccine and subsequent infection with influenza strain A/California/04/2009 H1N1pdm. Dual intranasalimmunization with vaccine compound consisting of 7.5 ?g of each hemagglutinin and 500 ?g of CTE in 50 ?l inducedreciprocal GMT on day 21 after immunization 40 (5-640) against H1N1pdm; 43.20 (5-1280) against H3N2; 10.80 (5-80)against influenza B. Animals with HI titers 1/80 against cell-derived antigen were completely protected against challengewith A/California/04/2009 H1N1pdm09