An Architectural Solution of Assistance e-Services for Diabetes Diet

The aim of this paper is to outline the requirements and main architecture for a useful tool for determining the nutrition facts of food for people having Type 2 Diabetes. This diabetes is used only to establish the target audience, a “mass of people†having, maybe, to less in common regarding the computer usage skills. The characteristics of the target audience (huge number, diversity of habits and behaviors, computer usage skills) requires a solution based on web services delivered at least partly as a standalone/ portable application, build from Web services and provided with means for domain knowledge dissemination and usage.Software Architecture, Knowledge Management, SIK, Business Rules, Type 2 Diabetes

BENEFITS OF USING SOFTWARE WITH SIK COMPLIANT ARCHITECTURE IN CLOUD

The aim of this paper is to investigate the main benefits that can be obtained by using a SIK (software inherited knowledge) compliant architecture for cloud services and support software used to build, administer and maintaining the cloud. It introduces the basic building blocks for cloud computing together with the main categories of cloud services. For the SIK architecture, shown in connection with a semantic-web application architecture, are introduced the main functionalities. The paper outlines then the main benefits different categories of users may have from both cloud and SIK compliant architecture for the cloud services delivered onto, for extensive knowledge management, and for creating the base for semantic-web for the modeled domain, the software oeration and usage, and automated administrative tasks for the cloud.software inherited knowledge, SIK, cloud-computing, knowledge management

THE ANALYSIS OF THE ECONOMIC GROWTH CAPACITY IN THE ROMANIAN CLOTHING INDUSTRY

The paper highlights the possibility of analysing the economic growth to a microeconomic level by personalizing it through an empirical study on the Romanian clothing industry. The integrated approach to performance in this study starts from the condition that it can be supported by the company's profit. The model proposed for the analysis also allows the analysis of the factors that influence the economic growth. The results of the empirical study show that the analysed company does not register sustainable economic growth due to the economic growth rate, which, during some periods, presents negative values

Molecular detection of Neospora caninum in slaughtered goat kids from Romania

Abstract. Although studies have been reported on Neospora caninum from goats, no study regarding N. caninum infection in goat kids was performed in Romania. The objective of this study was to determine the prevalence of N. caninum in goat kid tissues (diaphragm) by PCR. Diaphragm tissues were collected from 181 slaughtered goat kids, from 7 counties from center and north-west of Romania. All tissues were tested by PCR in order to identify N. caninum DNA. In two (1.1%) of the samples, collected from Alba and Hunedoara county, we found N. caninum DNA. The results obtained in this study have shown the presence of N. caninum in small ruminants. To our knowledge this is the first report about molecular prevalence of N. caninum in goat kids in Romania

PROFIT AND LOSS ACCOUNT – SYNTHETIC EXPRESSION OF ABSOLUTE RETURN

This study has as main objective the presentation of the current state of knowledge regarding the profit and loss account as part of the financial statements which express in absolute value the profitability of companies and the empirical analysis of these concepts based on the information submitted by OMV Petrom between 2011 and 2015. Thus, in the first part we present several approaches from the specialized literature regarding the aspects mentioned above. The second part follows a vertical and horizontal analysis of key indicators used for measuring the absolute return. For the horizontal analysis we pursued the evolution in time of the following indicators: Gross Margin, Earnings Before Interest and Taxes (EBIT), Financial Result, Gross and Net Result. The vertical analysis aimed to explain the formation of the Gross Result via EBIT (which was also analyzed through the Gross Margin and other specific elements) and of the Financial Result (which was also analyzed through the different types of financial income and expenses). The results of the study revealed problems of profitability in the years 2014 and 2015 which, in our opinion, can be attributed to poor management of the commercial activity, exploration activity (research and development), distribution and financial activity

Clinical and management aspects of the idiopathic thrombocytopenic purpura

Catedra Hematologie şi Oncologie a U.S.M.F. „N. Testemiţanu” (şeful catedrei – prof. univ., dr.hab.şt.med. I. Corcimaru), IMSP Institutul Oncologic (director – prof., dr.hab.şt.med. V. Cernat)The aspects of the clinical evolution, diagnosis and treatment of the idiopathic thrombocytopenic purpura were studied in 50 patients. It has been established that the disease developed mostly in young females. The hemorrhagic syndrome had the microcirculatory petechial-echymotic pattern. Although the direct clinico-hematologic response to the treatment with corticosteroid hormones was registered in 86% of patients, in all cases the platelets count decreased within the next 3 – 5 months up to the initial values. Splenectomy allowed to аchieve the recovery in 84% of patients. Particularităţile evoluţiei clinice, diagnosticului şi tratamentului purpurei trombocitopenice idiopatice au fost studiate la 50 pacienţi. A fost stabilit că maladia mai frecvent s-a dezvoltat la femei de vîrstă tînără. Sindromul hemoragic trombocitopenic a avut un caracter microcirculator peteşial-echimatos. Deşi răspunsul clinico-hematologic nemijlocit la tratamentul cu corticosteroizi a fost înregistrat la 86% de pacienţi, în toate cazurile peste 3 – 5 luni numărul trombocitar a scăzut pînă la valorile iniţiale. Splenectomia a permis de a obţine vindecare la 84% de pacienţi

Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer

Colon cancer is a widespread pathology with complex biochemical etiology based on a significant number of intracellular signaling pathways that play important roles in carcinogenesis, tumor proliferation and metastasis. These pathways function due to the action of key enzymes that can be used as targets for new anticancer drug development. Herein we report the synthesis and biological antiproliferative evaluation of a series of novel S-substituted 1H-3-R-5-mercapto-1,2,4-triazoles, on a colorectal cancer cell line, HT-29. Synthesized compounds were designed by docking based virtual screening (DBVS) of a previous constructed compound library against protein targets, known for their important role in colorectal cancer signaling: MEK1, ERK2, PDK1, VEGFR2. Among all synthesized structures, TZ55.7, which was retained as a possible PDK1 (phospholipid-dependent kinase 1) inhibitor, exhibited the most significant cytotoxic activity against HT-29 tumor cell line. The same compound alongside other two, TZ53.7 and TZ3a.7, led to a significant cell cycle arrest in both sub G0/G1 and G0/G1 phase. This study provides future perspectives for the development of new agents containing the 1,2,4-mercapto triazole scaffold with antiproliferative activities in colorectal cancer