SYNTHESIS OF FUNCTIONALIZED DIHYDROPYRROLES AND DIHYDROFURANS VIA INTRAMOLECULAR FURAN-YNE REACTION AND THEIR FURTHER ANNULATION

This work was supported by Russian Science Foundation (project 21-73-10063)

REARRANGEMENT OF FURYL-TETHERED OXIMES: SYNTHESIS OF FUNCTIONALIZED PYRROLES

This work was supported by the Russian Foundation for Basic Research, project # 20-33-70079

REARRANGEMENT OF FURYL-TETHERED OXIMES: SYNTHESIS OF FUNCTIONALIZED PYRROLES

Polyarylated pyrroles have been extensively utilized as building-blocks in material science. High demand for functionalyzed pyrrole substrates motivated us to develop a general synthetic protocol toward such valuable compounds based on furan dearomatization approach.This work was supported by the Russian Foundation for Basic Research, project # 20-33-70079

A review of the international early recommendations for departments organization and cancer management priorities during the global COVID-19 pandemic: applicability in low- and middle-income countries.

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a new virus that has never been identified in humans before. COVID-19 caused at the time of writing of this article, 2.5 million cases of infections in 193 countries with 165,000 deaths, including two-third in Europe. In this context, Oncology Departments of the affected countries had to adapt quickly their health system care and establish new organizations and priorities. Thus, numerous recommendations and therapeutic options have been reported to optimize therapy delivery to patients with chronic disease and cancer. Obviously, while these cancer care recommendations are immediately applicable in Europe, they may not be applicable in certain emerging and low- and middle-income countries (LMICs). In this review, we aimed to summarize these international guidelines in accordance with cancer types, making a synthesis for daily practice to protect patients, staff and tailor anti-cancer therapy delivery taking into account patients/tumour criteria and tools availability. Thus, we will discuss their applicability in the LMICs with different organizations, limited means and different constraints