Clinico-pathological prognostic factors in hematogenously disseminated colorectal cancer

Background: Ekberg`s criteria for liver resections (LR) of colorectal cancer liver metastases (CRCLM) have been accepted as a `dogma` and the procedure - as a `gold standard` since 1986. There are many wellknown predictive factors for the early and long-term results in this field of surgery. However, some of them are still a matter of debate.Aim: Study on the possible prognostic value of some clinical-pathological factors for the early and late results after major LR (≥ 2 segments) of CRCLM.Material and methods: A total of 143 radical (R0) major LR (≥ 2 segments) of synchronous and metachronous CRCLM were performed between 01.01.20007 - 31.12.2014 in the Clinic of Liver, Biliary, Pancreatic and General Surgery, Tokuda Hospital Sofia. The design of the study was `a single center` and `retrospective`. We analyzed the data with possible predictive value - demography, comorbidity, liver function, ASA group, neoadjuvant chemotherapy, type and characteristics of the surgical procedure, pathological data (T,N,G,H) and time of detection of metastases (synchronous or metachronous). The early postoperative morbidity and mortality rates were compared with these factors looking for correlation. The long-term follow-up period was ≥ 12 months for 86 patients (60.1%).Results: The early postoperative mortality rate was 2.8% (4 cases) for the whole series. The specific morbidity rates were significantly higher in patients above 65 years of age, with ≥ 3 comorbid conditions, multivisceral resections in cases of synchronous metastases and atypical (non-anatomical) LR. The majority of CRCLM cases were ≥ Т2, N (+) positive and G2-3. Unfavorable prognostic factors were the detection of metachronous lesions earlier than 12 months after a curative previous resection especially on the basis of adequate chemotherapy.Conclusions: The knowledge on prognostic factors in patients with CRCLM as well as on indications and contraindications helps the correct preoperative judgment on choosing the right and appropriate type and volume of surgical procedures

A review of the international early recommendations for departments organization and cancer management priorities during the global COVID-19 pandemic: applicability in low- and middle-income countries.

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a new virus that has never been identified in humans before. COVID-19 caused at the time of writing of this article, 2.5 million cases of infections in 193 countries with 165,000 deaths, including two-third in Europe. In this context, Oncology Departments of the affected countries had to adapt quickly their health system care and establish new organizations and priorities. Thus, numerous recommendations and therapeutic options have been reported to optimize therapy delivery to patients with chronic disease and cancer. Obviously, while these cancer care recommendations are immediately applicable in Europe, they may not be applicable in certain emerging and low- and middle-income countries (LMICs). In this review, we aimed to summarize these international guidelines in accordance with cancer types, making a synthesis for daily practice to protect patients, staff and tailor anti-cancer therapy delivery taking into account patients/tumour criteria and tools availability. Thus, we will discuss their applicability in the LMICs with different organizations, limited means and different constraints

Адресный волоконно-оптический датчик для измерения относительной влажности в комплектных распределительных устройствах

A number of governing documents and by-laws of the Russian Federation, branch ministries, departments and companies have introduced the use of measuring relative air humidity, elements insulation, and SF6 into operation and maintenance process of complete switchgear. A wide range of high-precision laboratory instruments has been developed to implement these measurements. However, as a rule, these are scheduled measurements to be carried out once or twice a quarter, although the constant on-line monitoring of humidity is concerned in both the production and scientific circles of the energy industry. The possibility of on-line monitoring appeared with the advent of fiber-optic object-based passive networks for collecting information and the possibility of forming interrogation channels in them, which is provided for by the development of the Smart Grid Plus concept. Fiber optic sensors, single in their physical layer structure with passive optical networks, are highly robust and resistant to high electromagnetic fields, typical of those generated in a switchgear, and are designed to operate in harsh environments. Among their broad class, fiber optic sensors on Bragg gratings, which differ from others by direct measurement methods, have significant advantages. In particular, an increase or decrease in relative humidity will lead to a corresponding change in the wavelength of the sensing source reflected from the grating, which can be measured with an accuracy of sixth place from its absolute value.This paper proposes to consider a two-element sensor of relative humidity of a parallel structure, which differs from the existing ones by using address fiber Bragg gratings made in SMF-28 fiber. One of the gratings has a polyimide-replaced quartz shell, synthesized using a reductant fiber coating, and a completely multiplicative response to temperature and deformation caused by humidity. The second grating is recorded in a standard fiber and responds only to temperature. It is possible to include an additional third grating with a partially etched cladding, which can be used for refract metric measurements of the amount of condensed moisture on the elements of a complete switchgear. All the gratings are identical, have, as a rule, the same Bragg wavelength after manipulating their claddings, but they have differing unique addresses, which are formed by recording two transparency windows in each of the gratings with different difference frequency space. The transparency windows correspond to phase p-shifts symmetrically located at the same distance from the center of each grating. The structure obtained makes it possible to record information of the measurement conversion at the said difference frequencies in the radio range, which significantly increases the speed of relative humidity measurements and their accuracy by an order of magnitude more. In addition to what has been said, it is possible to note the capability for building a network of these sensors in series arranged in switchgear devices, with a different radiofrequency address group being used in each of them.Рядом руководящих документов и подзаконных актов Российской Федерации, отраслевых министерств, ведомств и компаний измерение относительной влажности воздуха, изоляции элементов, элегаза введено в практику процесса эксплуатации и обслуживания комплектных распределительных устройств. Разработан широкий спектр высокоточных лабораторных приборов, которые используются для реализации указанных измерений. Однако, как правило, данные измерения проводятся планово, один-два раза в квартал, хотя о постоянном онлайн мониторинге влажности речь идет как в производственных, так и научных кругах энергетической отрасли. Возможность онлайн мониторинга появилась с появлением волоконно-оптических объектовых пассивных сетей сбора информации и возможности формирования в них сенсорных каналов, что предусмотрено также развитием концепции «Smart Grid Plus». Волоконно-оптические датчики, единые по структуре физического уровня с пассивными оптическими сетями, обладают высокой помехоустойчивостью, не подвержены влиянию мощных электромагнитных полей, характерных для создаваемых в комплектных распределительных устройствах, предназначены для работы в жестких условиях эксплуатации. Среди их широкого класса существенными преимуществами обладают волоконно-оптические датчики на брэгговских решетках, которые отличаются от других прямыми методами измерений. В частности, увеличение или уменьшение относительной влажности приведет к соответствующему изменению отраженной от решетки длины волны зондирующего источника, которая может быть измерена с точностью до шестого знака от ее абсолютного значения.В данной работе предложен к рассмотрению двухсенсорный датчик относительной влажности параллельной структуры, отличающийся от существующих использованием адресных волоконных брэгговских решеток, выполненных в волокне SMF-28. Одна из решеток имеет замененную полиимидом кварцевую оболочку, синтезированную с помощью восстановителя покрытия волокна, и полный мультипликативный отклик к температуре и деформации, вызванной влажностью. Вторая – представляет собой решетку, записанную в стандартном волокне, и реагирует только на температуру. Возможно включение дополнительной третьей решетки с частично вытравленной оболочкой, которая может быть применена для рефрактометрических измерений количества конденсированной влаги на элементах комплектного распределительного устройства. Все решетки идентичны, имеют, как правило, одинаковую длину волны Брэгга, после манипуляции над их оболочками, но отличаются уникальным адресом, который формируется записью двух окон прозрачности в каждой из решеток с различным разностным частотным пространством. Окна прозрачности соответствуют фазовым p-сдвигам, симметрично расположенным на одинаковом расстоянии от центра каждой из решеток. Полученная структура позволяет регистрировать информацию измерительного преобразования на указанных адресных разностных частотах в радиодиапазоне, что существенно повышает быстродействие измерений относительной влажности и их точность еще на порядок. В дополнение к сказанному можно отметить возможность построения сети указанных датчиков в последовательно расположенных комплектных распределительных устройствах, при этом в каждом из шкафов будет использована другая радиочастотная адресная группа

COMBINE COMMUNICATIONS OPTICAL NETWORK OF SCADA OF ELECTRIC POWER STATION AND SUBSTATION

The article discusses an economical way to deploy diagnostic monitoring systems for high-voltage electrical units through a combination of passive fiber-optic systems for collecting and transmitting technological information of SCADA with diagnostic information transmission systems of systems for continuous technical diagnostics in them. The usage of existing communication network of SCADA will increase economy and expand the scope of continuous diagnostic systems