Trajectory Clustering for Air Traffic Categorisation

Availability of different types of data and advances in data-driven techniques open the path to more detailed analyses of various phenomena. Here, we examine the insights that can be gained through the analysis of historical flight trajectories, using data mining techniques. The goal is to learn about usual (or nominal) choices airlines make in terms of routing, and their relation with aircraft types and operational flight costs. The clustering is applied to intra-European trajectories during one entire summer season, and a statistical test of independence is used to evaluate the relations between the variables of interest. Even though about half of all flights are less than 1000 km long, and mostly operated by one airline, along one trajectory, the analysis shows that, for longer flights, there exists a clear relation between the trajectory clusters and the operating airlines (in about 49% of city pairs) and/or the aircraft types (30%), and/or the flight costs (45%)

Summer ecology and behavior of the grayling of McManus Creek, Alaska

Thesis (M.S.) University of Alaska Fairbanks, 1970A study of the summer ecology and behavior of the Arctic Grayling was undertaken on the summer population of McManus Creek, Alaska. An effort to determine the distribution and the patterns of the fish’s movements in the stream was made. The grayling spent the summer months in pools where they established feeding territories. Within each feeding territory a feeding range, where all feeding activities took place, was found. In each pool a hierarchial ordering based on a dominant subordinate relationship existed. This hierarchy was established and maintained by a series of displays. The grayling of McManus Creek were found to feed solely on the surface and at mid-depth. The food items consisted both of flying insects and aquatic insects, the latter making up the largest portion of their diet. It appeared that the fish relied primarily upon benthic drift for nutrition. Being visual feeders, the fish were unable to utilize the large numbers of organisms known to drift during periods of high and muddy water.Research on McManus Creek, Alaska, was financed by grants from the Institute of Water Resources Research of the University of Alaska to Dr. James E. Morrow, Professor of Zoology, Department of. Biological Sciences

Mitochondrial DNA Repair in Neurodegenerative Diseases and Ageing

Mitochondria are the only organelles, along with the nucleus, that have their own DNA. Mitochondrial DNA (mtDNA) is a double-stranded circular molecule of ~16.5 kbp that can exist in multiple copies within the organelle. Both strands are translated and encode for 22 tRNAs, 2 rRNAs, and 13 proteins. mtDNA molecules are anchored to the inner mitochondrial membrane and, in association with proteins, form a structure called nucleoid, which exerts a structural and protective function. Indeed, mitochondria have evolved mechanisms necessary to protect their DNA from chemical and physical lesions such as DNA repair pathways similar to those present in the nucleus. However, there are mitochondria-specific mechanisms such as rapid mtDNA turnover, fission, fusion, and mitophagy. Nevertheless, mtDNA mutations may be abundant in somatic tissue due mainly to the proximity of the mtDNA to the oxidative phosphorylation (OXPHOS) system and, consequently, to the reactive oxygen species (ROS) formed during ATP production. In this review, we summarise the most common types of mtDNA lesions and mitochondria repair mechanisms. The second part of the review focuses on the physiological role of mtDNA damage in ageing and the effect of mtDNA mutations in neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Considering the central role of mitochondria in maintaining cellular homeostasis, the analysis of mitochondrial function is a central point for developing personalised medicine

Integration of VICbus, FDL, SCI and Ethernet in the CERN CASCADE data acquisition system

Cascade is a multi-processor real-time data-acquisition system for HEP experiments developed at CERN by the ECP-DS group. Configurations supported today include VMEbus processors running OS-9 and UNIX workstations. The CASCADE data acquisition processes, called stages communicate via links, at present VICbus between VME crates and Ethernet between VMEbus processors and workstations. Work is in progress to introduce new inter-stage links based on the Fast Data Link between VME crates and on SCI for data exchange between SUN stations. The paper gives a short description of the architecture of CASCADE with emphasis on the link aspects. The implementation and current status of the inter-stage links based on VICbus, Ethernet, FDI, and SCI will be described and results on the performances presented

Review and prospects of the CASCADE data acquisition system at CERN

CASCADE, a multi-processor real-time data-acquisition system for HEP experiments developed at CERN by the ECP-DS group, has now been in operation for one year. The current implementation supports configurations based on VMEbus processors running OS-9 and on UNIX workstations interconnected via VICbus or Ethernet. The project is reviewed by describing the main characteristics of the package, the applications in which it has been used, and the results of this experience. The main improvements of 1994, which include a parameterized multi-level event builder, a remote monitoring option and a powerful run control facility, as well as ongoing developments and prospects for 1995, are presented

RadioLab project: knowledge of radon gas in Italy

AbstractRadioLab is an Italian project, addressed to school-age people, and designed for the dissemination of scientific culture on the theme of environmental radioactivity, with particular regards to the importance of knowledge of radon gas exposure. The project is a nationwide initiative promoted by the National Institute of Nuclear Physics- INFN. First tool used by the project, and of immediate impact to assess the public awareness on radon, is the administration of the survey “do you know the radon gas?”. In the survey, together with the knowledge of radon and of its sources, information on personal, cultural and territorial details regarding the interviewees are also taken. Reasonably, the survey invests not only young people, but also their relatives, school workers and, gradually, the public. The survey is administrated during exhibitions or outreach events devoted to schools, but also open to the public. The survey is in dual form: printed and online. The online mode clearly leads RadioLab project even outside the school environment. Based on the results of the survey, several statistical analyses have been performed and many conclusions are drawn about the knowledge of the population on the radon risk. The RadioLab benefit and the requirement to carry on the project goals, spreading awareness of environmental radioactivity from radon, emerge. The dataset involves all twenty Italian regions and consists of 28,612 entries covering the 5-year period 2018–2022

Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome

Abundant ribonucleoside-triphosphate (rNTP) incorporation into DNA by DNA polymerases in the form of ribonucleoside monophosphates (rNMPs) is a widespread phenomenon in nature, resulting in DNA-structural change and genome instability. The rNMP distribution, characteristics, hotspots and association with DNA metabolic processes in human mitochondrial DNA (hmtDNA) remain mostly unknown. Here, we utilize the ribose-seq technique to capture embedded rNMPs in hmtDNA of six different cell types. In most cell types, the rNMPs are preferentially embedded on the light strand of hmtDNA with a strong bias towards rCMPs; while in the liver-tissue cells, the rNMPs are predominately found on the heavy strand. We uncover common rNMP hotspots and conserved rNMP-enriched zones across the entire hmtDNA, including in the control region, which links the rNMP presence to the frequent hmtDNA replication-failure events. We show a strong correlation between coding-sequence size and rNMP-embedment frequency per nucleotide on the non-template, light strand in all cell types, supporting the presence of transient RNA-DNA hybrids preceding light-strand replication. Moreover, we detect rNMP-embedment patterns that are only partly conserved across the different cell types and are distinct from those found in yeast mtDNA. The study opens new research directions to understand the biology of hmtDNA and genomic rNMPs.Graphical Abstrac

New results from the NA57 experiment

We report results from the experiment NA57 at CERN SPS on hyperon production at midrapidity in Pb-Pb collisions at 158 $A$ GeV/$c$ and 40 $A$ GeV/$c$. $\Lambda$, $\Xi$ and $\Omega$ yields are compared with those from the STAR experiment at the higher energy of the BNL RHIC. $\Lambda$, $\Xi$, $\Omega$\ and preliminary $K_S^0$ transverse mass spectra are presented and interpreted within the framework of a hydro-dynamical blast wave model.Comment: 8 pages, 3 figures, contribution to the proceedings of The XXXVIIIth Rencontres de Moriond "QCD and High Energy Hadronic Interactions