VERTICAL AND HORIZONTAL FORCES DURING CUTIING IN BASKETBALL UNDER DIFFERENT CONDITIONS

The purpose of this study is to evaluate ground reaction force responses in professional basketball athletes while executing this sport's typical cutting maneuver with and without ankle bracing: taping, aircast-type orthosis and basketball shoes. Eight athletes were dynamically analyzed during a basketball cutting maneuver with a force platform. We collected vertical and medial-lateral forces under these three conditions and analyzed force peaks of foot contact with the ground and propulsion and growth gradient for these forces. Results show that bracing did not significantly change Fymax1 and GCFymax1; significantly reduced Fymax2 and GG Fymax2. With respect to the medial-lateral component, there were no significant differences in relation to force magnitudes between the three study conditions. However, GG Fzmax1 was significantly greater for the sport shoe condition than for the taping condition. Bracing decreased ground reaction force at some instances, but increased in others

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality