Vasospastic angina and its relationship with the coronary microcirculation

Vasospastic angina is an import cause of chest pain due to coronary artery vasospasm that is related with poor quality of life and can lead to myocardial infarction, arrhythmias and death. Since its first description as "Prinzmetal or variant angina" which was believed to be a focal spam that occurred in non-obstructed epicardial coronary arteries, physician and researchers were gradually, confronted with the clinical reality, and came to the conclusion that the coronary artery vasospasm was considerably more polymorphic than initially described. Although mechanism leading to vasospastic angina are not completely understood today the medical community acknowledges that it exhibit a large variability in clinical practice ranging from focal to diffuse epicardial vasospasm. Main proposed mechanism are impairment of parasympathetic activity, coronary vascular and microvascular dysfunction due to blunted response to nitric oxide endothelium-dependent coronary vasodilatation, increased release of vasoconstricts, and oxidative stress

Pityriasis lichenoides getriggert durch eine Masern‐Mumps‐Röteln‐Impfung

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Keratosis lichenoides chronica mit untypischer klinischer Präsentation und variblen histopathologischen Merkmalen

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Pigmented purpuric dermatoses: analysis of epidemiological, clinical and histopathological aspects in relation to the prognosis of 70 patients, including infants and adults

Pigmented purpuric dermatoses (PPDs) are a group of chronic-relapsing, inflammatory purpuras without vasculitis that typically involve the lower limbs. Five major types could be distinguished, according to the clinical and histopathologic analysis. The etiopathogenesis is still unknown and multiple factors have been considered. Prognosis seems not to be influenced by the different clinical forms of PPDs; nevertheless no previous studies have investigated whether it could be influenced by the anatomical distribution of the disease

Clizia o della mala contentezza degli uomini

Il contributo mira a offrire alcune riflessioni sui personaggi della Clizia di Machiavelli e un'analisi lessicografico-linguistica