Interesting Properties of p-, d-, and f-Block Elements When Coordinated With Dipicolinic Acid and Its Derivatives as Ligands: Their Use as Inorganic Pharmaceuticals

This is a review of the literature concerning the interesting properties of p-, d-, and f-block elements when coordinated with 2,6-pyridinedicarboxylic acid (dipicolinic acid, H2dipic) and its derivatives as ligands, with a focus on their use as inorganic pharmaceuticals. Some of the complexes reported were used as insulin-like, bioimaging contrasting agents, antimicrobial agents, and anticancer agents

Tetra-μ-aqua-octaaqua­bis(μ-4-chloro­pyridine-2,6-dicarboxyl­ato)bis­(4-chloro­pyridine-2,6-dicarboxyl­ato)tri­cobalt(II)disodium(I) bis­[triaqua­bis(4-chloro­pyridine-2,6-dicarboxyl­ato)cobalt(II)] hexa­hydrate

The title compound, [Co3Na2(C7H2ClNO4)4(H2O)12][Co(C7H2ClNO4)(H2O)3]2·6H2O, consists of a centrosymmetric dimer of [CoII(dipicCl)2]2− complex dianions [dipicCl is 4-chloro­pyridine-2,6-dicarboxyl­ate] bridged by an [Na2CoII(H2O)12]4+ tetra­cationic cluster, two independent [Co(dipicCl)(H2O)3] complexes, and six water mol­ecules of crystallization. The metals are all six-coordinate with distorted octahedral geometries. The [CoII(dipicCl)(H2O)3] complexes are neutral, with one tridentate ligand and three water molecules. The [CoII(dipicCl)2]2− complexes each have two tridentate ligands. The [Na2CoII(H2O)12]4+ cluster has a central CoII ion which is coordinated to six water molecules and lies on a crystallographic inversion center. Four of the water molecules bridge to two sodium ions, each of which have three other water molecules coordinated along with an O atom from the [CoII(dipicCl)2]2− complex. In the crystal structure, the various units are linked by O—H⋯O hydrogen bonds, forming a three-dimensional network. Two water molecules are disordered equally over two positions

CCDC 706305: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.,Related Article: V.H.Rambaran, S.Balof, L.Moody, D.VanDerveer, A.A.Holden|2009|CrystEngComm|11|580|doi:10.1039/b822030

A New and Efficient Synthetic Route for the Synthesis of 3,6-Dimethylpyrazine-2,5-Dicarboxylic Acid Hydrate: Molecular Structure and Unique Supramolecular Interactions

The regioselective oxidation of 2,3,5,6,-tetramethyl pyrazine by selenium dioxide and silver nitrate resulted in the production of, 3,6-dimethylpyrazine-2,5-dicarboxylic acid hydrate in high yields. Its crystal structure, which is reported for the very first time, consists of a unique infinite three-dimensional lattice of hydrogen-bonded acid and water molecules

CCDC 674276: Experimental Crystal Structure Determination

Related Article: L.Moody, S.Balof, S.Smith, V.H.Rambaran, D.VanDerveer, A.A.Holder|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|m262|doi:10.1107/S1600536807067141,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

Tetra-\u3ci\u3eμ\u3c/i\u3e-aqua-octaaquabis(\u3ci\u3eμ\u3c/i\u3e-4-chloropyridine-2,6-dicarboxylato(bis(4-chloro-pyridine-2,6-dicarboxylato)tricobalt(II)-disodium(I) Bis[triaquabis(4-chloro-pyridine-2,6-dicarboxylato)cobalt(II)] Hexahydrate

The title compound, [Co3Na2(C72ClNO4)4(H2O)12][Co(C7H2ClNO4(H2O)3]2·6H2O, consists of a centrosymmetric dimer of [CoII(dipicCl)2]2- complex dianions [dipicCl is 4-chloro­pyridine-2,6-dicarboxyl­ate] bridged by an [Na2CoII(H2O)12]4+ tetra­cationic cluster, two independent [Co(dipicCl)(H2O)3] complexes, and six water mol­ecules of crystallization. The metals are all six-coordinate with distorted octahedral geometries. The [CoII(dipicCl)(H2O)3] complexes are neutral, with one tridentate ligand and three water molecules. The [CoII(dipicCl)2]2- complexes each have two tridentate ligands. The [Na2CoII(H2O)12]4+ cluster has a central CoII ion which is coordinated to six water molecules and lies on a crystallographic inversion center. Four of the water molecules bridge to two sodium ions, each of which have three other water molecules coordinated along with an O atom from the [CoII(dipicCl)2]2- complex. In the crystal structure, the various units are linked by O-H···O hydrogen bonds, forming a three-dimensional network. Two water molecules are disordered equally over two positions

Electrochemical and Electrogenerated Chemiluminescent Studies of a Trinuclear Complex, [((phen)\u3csub\u3e2\u3c/sub\u3eRu(dpp))\u3csub\u3e2\u3c/sub\u3eRhCl\u3csub\u3e2\u3c/sub\u3e]\u3csup\u3e5+\u3c/sup\u3e, and its Interactions with Calf Thymus DNA

The electrochemical behavior of a trinuclear ruthenium(H)containing complex, [((phen)2Ru(dpP))2RhCl2]5+ (where phen = 1,10-phenanthroline, dpp = 2,3-bis(2-pyridyl)pyrazine), was studied in acetonitrile (MeCN) and aqueous solutions. In MeCN containing 0.10 M tetra-n-butylammonium perchlorate (TBAP), the complex displayed a reversible, overlapping RuII/III redox process with E1/2 = +1.21 V vs Ag/Ag+ (10 mM), an irreversible reduction of RhIII/I at -0.73 V vs Ag/Ag+, and two quasi-reversible dpp/dpp- couples with E1/2 = -1.11 and -1.36 V vs Ag/Ag+ at a Pt electrode with a scan rate of 50 mV s-1. In 0.20 M Tris buffer solution (pH 7.4), an irreversible, overlapping RuII/III oxidation at +1.48 V vs Ag/AgCl (3 M KCl), and an irreversible reduction of Rh-III/II at -0.78 V vs Ag/AgCl were observed at a glassy carbon electrode with a scan rate of 50 mV/s. Investigations on the electrogenerated chemiluminescence (ECL) of the complex revealed that 2-(dibutylamino) ethanol (DBAE) was superior to tri-n-propylamine (TPrA) as an ECL coreactant within their entire concentration range of 10-100 mM in MeCN, and in aqueous media, as low as 1.0 nM of the complex can be detected using TPrA coreactant ECL. A maximum ECL emission of 640 nm, which is about 55 run blue shift to its fluorescence, was observed in MeCN with DBAE as a coreactant. Interactions of the complex with calf thymus DNA (ctDNA) were conducted with a flow-cell based quartz-crystal microbalance, and a binding constant of 2.5 x 105 M-1 was calculated on the basis of the Langmuir isotherm equation

CCDC 908444: Experimental Crystal Structure Determination

Related Article: Varma H. Rambaran, Travis R. Erves, Kristy Grover, Shawna Balof, LaMaryet V. Moody, Stuart E. Ramsdale, Luke A. Seymour, Don VanDerveer, Donald M. Cropek, Ralph T. Weber, Alvin A. Holder|2013|J.Chem.Cryst.|43|509|doi:10.1007/s10870-013-0437-7,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 908445: Experimental Crystal Structure Determination

Related Article: Varma H. Rambaran, Travis R. Erves, Kristy Grover, Shawna Balof, LaMaryet V. Moody, Stuart E. Ramsdale, Luke A. Seymour, Don VanDerveer, Donald M. Cropek, Ralph T. Weber, Alvin A. Holder|2013|J.Chem.Cryst.|43|509|doi:10.1007/s10870-013-0437-7,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

A Comparison of the Self Assembled Frameworks of Three Cobalt(II) Coordination Compounds Bearing Dipicolinic Acid and Chelidamic Acid Ligands

A comparison of the self assembled lattice structures of unpublished coordination compound, [Co(dipic-OH)(OH2)3]·1.5H2O (I) (where dipic-OH = 4-hydroxypyridine-2,6-dicarboxylate anion) and two novel cobalt(II)-containing coordination compounds, [Co(dipic)(pyz)(OH2)]·0.25DMSO (II) (where dipic = dipicolinate anion and pyz = 2-(H-pyrazol-3-yl)-pyridine) and [Co(dipic-OH)(pyz)(OH2)]·H2O (III), have revealed remarkable distinctions in the hierarchy of their respective structures. The three dimensional (3-D) layered scaffold of compound I and the “zigzag” motifs of compounds II and III were found to have been created via unique hydrogen bonding patterns. Interestingly, compound III displayed a secondary 3-D channel framework, which was made possible by π–π stacking interactions. Spectroscopic studies yielded results that were consistent with the predicted behaviors of the various species of substituted ligands. X-ray crystallography revealed that compound I crystallized in the monoclinic space group C2/c with a = 14.734(3) Å, b = 6.8664(14) Å, c = 22.411(5) Å, α = 90°, β = 90.097(7)°, γ = 90°, V = 2267.4(8) Å3, Z = 8; compound II crystallized in the monoclinic space group P21/n with a = 11.621(3) Å, b = 12.391(3) Å, c = 12.537(4) Å, α = 90°, β = 102.148(11)°, γ = 90°, V = 1764.8(8) Å3, Z = 4; and compound III crystallized in the orthorhombic space group Pccn with a = 21.899(2) Å, b = 10.8845(11) Å, c = 15.7093(13) Å, α = 90°, β = 90°, γ = 90°, V = 3744.4(6) Å3, Z = 8