Tympanometric results from neonates and infants under four months

Advantages of objective studying the middle ear of infants and neonates are presented. High frequency timpanometry is proposed and used because of anatomical differences between children and adults. This method is used widely in diagnosing, because he is noninvasive, quick and easy to perform

Results in the development of speech in bilingual children with a cochlear implant

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Промени в подбора на пациентите за кохлеарна имплантация

Авторите представят развитието на проблема, основанията и резултатите от прилагането на оперативната интервенция кохлеарна имплантация за лечение на трайни дефицити в чуването. Разглеждат се новите индикации по отношение възрастта, запазване на остатъчния слух, генетичните слухови увреди, едностранната глухота, невропатията и необходимостта от двустранна кохлеарна имплантация при деца и възрастни

Psychological and pedagogical support for students’ adaptation to learning activity in high science school

© 2016 by iSER, International Society of Educational Research.The relevance of the study is due to the importance of psychological and pedagogical support for students in university that would prevent difficulties in learning activities and increase adaptive capacity through the development of relevant personal traits. Therefore, this article is aimed at solving the problem of arranging psychological and pedagogical support for first-year students’ entry to a new system of educational activity. The key approach to the study of this problem is the system-activity approach, which allows to introduce training activities as a collaborative work with one of its members (the student) gaining experience and others creating facilities for it. The article describes the developed and implemented model of psychological and pedagogical support for student adaptation to educational activity in high school with a key role of tutoring program. The empirical data on the results of program approbation are also under consideration. With the help of system-activity approach the courses "Training activities technology" and "Life science" were adopted, the content of which is revealed in this article. The article may be useful to teachers and tutors, working within the framework of vocational training of students

Tips for Programming the Speech Processor

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CpG-island methylation of the ER promoter in colorectal cancer: analysis of micrometastases in lymph nodes from UICC stage I and II patients

Patients with UICC stage II colorectal cancer (CRC) have a risk of approximately 20% to develop disease recurrence after tumour resection. The presence and significance of micrometastases for locoregional recurrence in these patients lacking histopathological lymph node involvement on routine stained HE sections is undefined. Oestrogen receptor (ER) promoter methylation has earlier been identified in CRC. Therefore, we evaluated the methylation status of the ER promoter in lymph nodes from 49 patients with CRC UICC stage I and II as a molecular marker of micrometastases and predictor of local recurrence. DNA from 574 paraffin-embedded lymph nodes was isolated and treated with bisulphite. For the detection of methylated ER promoter sequences, quantitative real-time methylation-specific PCR was used. Of the 49 patients tested, 15 (31%) had ER methylation-positive lymph nodes. Thirteen of those (86%) remained disease free and two (14%) developed local recurrence. In the resected lymph nodes of 34 of the 49 patients (69%), no ER promoter methylation could be detected and none of these patients experienced a local relapse. The methylation status of the ER promoter in lymph nodes of UICC stage I and II CRC patients may be a useful marker for the identification of patients at a high risk for local recurrence