Prospettiva e Valore della matrice Cheratinica nella valutazione dell'utilizzo di Nuove Sostanze Psicoattive nella popolazione che afferisce ai SERD

Questo articolo nasce dall'esigenza di informare un pi&amp;ugrave; ampio pubblico sul pericolo rappresentato da queste sostanze, far conoscere le NPS (Novel Psychoactive substances) agli operatori del settore (personale di laboratorio, personale delle unit&amp;agrave; di emergenza/ urgenza, operatori sanitari, ricercatori, ecc.) al fine di agevolare l'analisi di campioni sconosciuti e divulgare i dati scientifici che cominciano ad emergere da studi clinici e preclinici sui loro effetti tossici e farmacologici.&amp;nbsp;Dal 2009 sono comparsi nel gruppo delle N.P.S., i nuovi oppioidi sintetici, molecole estremamente potenti che comportano una seria minaccia per la salute pubblica. Si tratta di prodotti dalla notevole potenza (il fentanyl, per esempio, capostipite di questa famiglia, ha un'azione circa 100 volte maggiore rispetto a quella della morfina) che vengono utilizzati sia per s&amp;eacute; sia come adulteranti di partite di sostanze classiche, soprattutto eroina, causando scie di decessi per overdose.&amp;nbsp;</jats:p

Un percorso di integrazione tra strutture ospedaliere e servizi territoriali

The forty years of work in the Ser.D. have taught us to grasp changes, often beyond laws and resources, proposing the correct organizational evolutions. The evolution of consumption and states of dependence, the new consumption of young people, the challenges to the limit of risks, the addictive behaviors such as chemic sex recall the need for new reading paradigms, a new clinic and new operational tools. A collaboration between the SMEL Clinical Chemical Analysis and Microbiology Laboratory of the Lodi Hospital and the Ser.D. has begun a few months ago, aimed at introducing a new protocol for the research of substances of abuse on the keratin matrix in drug addiction monitoring. Furthermore, with this type of analysis, the laboratory can provide its Ser.D. with a more effective analysis tool in monitoring patients. The high specificity of the test is able to determine greater diagnostic reliability with a consequent improvement in the specificity of treatment.</jats:p

Sites of Autologous Bone Grafts in Orthopaedic Traumatology. Analysis of complications

Background: The use of autologous bone graft in orthopaedic traumatology is not uncommon. But little work, from West African subregion, has been devoted to sites used as sources of autologous bone grafts. Objective: The purpose of this study was to evaluate the evolution of these different sampling sites of autologous graft. Materials and methods: The authors report the results of a retrospective study of 84 patients operated on between 2000 and 2005 for various bone diseases requiring autologous bone graft at CHU Treichville (in Abidjan). Excluded from this study were bone grafts sourced from femoral heads harvested during arthroplasty of the hip. The series consist of 52 men and 32 women. Sites of bone autografts were iliac in 55 patients, 18 ends of the upper tibia, 7 olecranons, 3 fibulas and 1 greater trochanter of the femur. The evaluation of patients was clinical and radiographic and included the existence or not of pain, stiffness, assessment of the scar and the existence of a local deformation. Results: Outcome was satisfactory in 72 patients. 6 patients reported pain in the iliac crest. In 11 patients, the scar to the iliac crest was unsightly. Conclusion: The authors conclude that the commonly used donor sites for autologous bone grafts are safe. Keywords:autologous bone graft, pseudoarthrosis, bone reconstructionNigerian Journal of Orthopaedics and Trauma Vol. 7 (1) 2008 pp. 20-2

Adamantinoma of the Tibia: A Case Report

Introduction: Adamantinoma is a bone tumor which is commonly showed in mandible. Its occurrence in long bones constitutes a rare affection and a difficult histological diagnosis This rare malignant tumor of mesenchymal and epithelial origin was discovered in the tibia of a male patient. Case Report: The authors report a case of adamantinoma of the tibia in a 36- years old. He presented with slowly progressing leg swelling that evolved over 2 years without significant clinical manifestation. Complementary examination and investigation did not help in differential diagnosis and confirmation was only possible after histological examination. There was increase in size of lesion with increased pain and patie3nt presented with pathological fracture. Local extension of the tumor indicated an amputation of leg. The histological exam of the amputation specimen confirmed the results of the initial biopsy by showing cells tumorales in favour of an adamantinoma. After a good medium-term follow up, the patient died secondary to lung metastases. The authors discuss their method of diagnosis and therapeutics in front of such tumor. Conclusion: Adamantinoma is characterized by a slow clinical development marked by the prevalence of lung metastases and local recurrences. After the diagnosis, there must be a complete and sufficient surgery to avoid a local recurrence or metastasis. Keywords: Adamantinoma, Tibia, Tumo